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Fusion gene ID: 30467 |
FusionGeneSummary for RARA_IGFBP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RARA_IGFBP4 | Fusion gene ID: 30467 | Hgene | Tgene | Gene symbol | RARA | IGFBP4 | Gene ID | 5914 | 3487 |
| Gene name | retinoic acid receptor alpha | insulin like growth factor binding protein 4 | |
| Synonyms | NR1B1|RAR | BP-4|HT29-IGFBP|IBP4|IGFBP-4 | |
| Cytomap | 17q21.2 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | retinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2 | insulin-like growth factor-binding protein 4IBP-4IGF-binding protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P10276 | P22692 | |
| Ensembl transtripts involved in fusion gene | ENST00000254066, ENST00000394089, ENST00000425707, ENST00000394086, ENST00000394081, ENST00000420042, | ENST00000542955, ENST00000269593, | |
| Fusion gene scores | * DoF score | 29 X 12 X 7=2436 | 7 X 7 X 3=147 |
| # samples | 42 | 9 | |
| ** MAII score | log2(42/2436*10)=-2.53605290024021 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/147*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RARA [Title/Abstract] AND IGFBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RARA | GO:0007165 | signal transduction | 2825025 |
| Hgene | RARA | GO:0030853 | negative regulation of granulocyte differentiation | 19917671 |
| Hgene | RARA | GO:0032689 | negative regulation of interferon-gamma production | 18416830 |
| Hgene | RARA | GO:0032720 | negative regulation of tumor necrosis factor production | 18416830 |
| Hgene | RARA | GO:0032736 | positive regulation of interleukin-13 production | 18416830 |
| Hgene | RARA | GO:0032753 | positive regulation of interleukin-4 production | 18416830 |
| Hgene | RARA | GO:0032754 | positive regulation of interleukin-5 production | 18416830 |
| Hgene | RARA | GO:0045630 | positive regulation of T-helper 2 cell differentiation | 18416830 |
| Hgene | RARA | GO:0045892 | negative regulation of transcription, DNA-templated | 20080953 |
| Hgene | RARA | GO:0045893 | positive regulation of transcription, DNA-templated | 18845237|19850744|20080953 |
| Hgene | RARA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19850744 |
| Hgene | RARA | GO:0071300 | cellular response to retinoic acid | 19917671 |
| Hgene | RARA | GO:0071391 | cellular response to estrogen stimulus | 20080953 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A1KN-01A | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254066 | ENST00000542955 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| In-frame | ENST00000254066 | ENST00000269593 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| In-frame | ENST00000394089 | ENST00000542955 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| In-frame | ENST00000394089 | ENST00000269593 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| In-frame | ENST00000425707 | ENST00000542955 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| In-frame | ENST00000425707 | ENST00000269593 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| intron-3CDS | ENST00000394086 | ENST00000542955 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| intron-3CDS | ENST00000394086 | ENST00000269593 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| intron-3CDS | ENST00000394081 | ENST00000542955 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| intron-3CDS | ENST00000394081 | ENST00000269593 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| intron-3CDS | ENST00000420042 | ENST00000542955 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
| intron-3CDS | ENST00000420042 | ENST00000269593 | RARA | chr17 | 38487648 | + | IGFBP4 | chr17 | 38609237 | + |
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FusionProtFeatures for RARA_IGFBP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RARA | IGFBP4 |
| Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence of ligand, the RXR-RAR heterodimers associate with amultiprotein complex containing transcription corepressors thatinduce histone acetylation, chromatin condensation andtranscriptional suppression. On ligand binding, the corepressorsdissociate from the receptors and associate with the coactivatorsleading to transcriptional activation. RARA plays an essentialrole in the regulation of retinoic acid-induced germ celldevelopment during spermatogenesis. Has a role in the survival ofearly spermatocytes at the beginning prophase of meiosis. InSertoli cells, may promote the survival and development of earlymeiotic prophase spermatocytes. In concert with RARG, required forskeletal growth, matrix homeostasis and growth plate function (Bysimilarity). {ECO:0000250|UniProtKB:P11416,ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19850744,ECO:0000269|PubMed:20215566}. | IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >IGFBP4 | chr17:38487648 | chr17:38609237 | ENST00000269593 | + | 0 | 4 | 171_249 | 116 | 259 | Domain | Thyroglobulin type-1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 88_153 | 59 | 463 | DNA binding | Nuclear receptor |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 88_153 | -114 | 458 | DNA binding | Nuclear receptor |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 88_153 | 59 | 463 | DNA binding | Nuclear receptor |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 88_153 | 59 | 366 | DNA binding | Nuclear receptor |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 183_417 | 59 | 463 | Domain | NR LBD |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 183_417 | -114 | 458 | Domain | NR LBD |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 183_417 | 59 | 463 | Domain | NR LBD |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 183_417 | 59 | 366 | Domain | NR LBD |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 154_182 | 59 | 463 | Region | Note=Hinge |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 1_87 | 59 | 463 | Region | Note=Modulating |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 404_419 | 59 | 463 | Region | Note=Required for binding corepressor NCOR1 |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 154_182 | -114 | 458 | Region | Note=Hinge |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 1_87 | -114 | 458 | Region | Note=Modulating |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 404_419 | -114 | 458 | Region | Note=Required for binding corepressor NCOR1 |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 154_182 | 59 | 463 | Region | Note=Hinge |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 1_87 | 59 | 463 | Region | Note=Modulating |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 404_419 | 59 | 463 | Region | Note=Required for binding corepressor NCOR1 |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 154_182 | 59 | 366 | Region | Note=Hinge |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 1_87 | 59 | 366 | Region | Note=Modulating |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 404_419 | 59 | 366 | Region | Note=Required for binding corepressor NCOR1 |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 124_148 | 59 | 463 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000254066 | + | 2 | 9 | 88_108 | 59 | 463 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 124_148 | -114 | 458 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394081 | + | 1 | 8 | 88_108 | -114 | 458 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 124_148 | 59 | 463 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000394089 | + | 2 | 9 | 88_108 | 59 | 463 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 124_148 | 59 | 366 | Zinc finger | NR C4-type |
| Hgene | >RARA | chr17:38487648 | chr17:38609237 | ENST00000425707 | + | 2 | 7 | 88_108 | 59 | 366 | Zinc finger | NR C4-type |
| Tgene | IGFBP4 | chr17:38487648 | chr17:38609237 | ENST00000269593 | + | 0 | 4 | 23_103 | 116 | 259 | Domain | IGFBP N-terminal |
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FusionGeneSequence for RARA_IGFBP4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RARA_ENST00000254066_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_202aa MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGTSTPSPANKDEGDHPNNSFSPCSAHDRRCLQKHFAKIR DRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKL >In-frame_RARA_ENST00000254066_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_202aa MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGTSTPSPANKDEGDHPNNSFSPCSAHDRRCLQKHFAKIR DRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKL >In-frame_RARA_ENST00000394089_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_202aa MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGTSTPSPANKDEGDHPNNSFSPCSAHDRRCLQKHFAKIR DRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKL >In-frame_RARA_ENST00000394089_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_202aa MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGTSTPSPANKDEGDHPNNSFSPCSAHDRRCLQKHFAKIR DRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKL >In-frame_RARA_ENST00000425707_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_202aa MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGTSTPSPANKDEGDHPNNSFSPCSAHDRRCLQKHFAKIR DRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKL >In-frame_RARA_ENST00000425707_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_202aa MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGTSTPSPANKDEGDHPNNSFSPCSAHDRRCLQKHFAKIR DRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RARA_ENST00000254066_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_606nt ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCT ATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAAC AAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGA GACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAG CTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAAC GGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTT >In-frame_RARA_ENST00000254066_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_606nt ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCT ATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAAC AAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGA GACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAG CTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAAC GGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTT >In-frame_RARA_ENST00000394089_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_606nt ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCT ATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAAC AAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGA GACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAG CTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAAC GGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTT >In-frame_RARA_ENST00000394089_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_606nt ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCT ATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAAC AAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGA GACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAG CTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAAC GGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTT >In-frame_RARA_ENST00000425707_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_606nt ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCT ATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAAC AAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGA GACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAG CTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAAC GGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTT >In-frame_RARA_ENST00000425707_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_606nt ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCT ATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAAC AAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGA GACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAG CTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAAC GGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RARA_ENST00000254066_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_1561nt CAGAAGCAGGGGGGAATCCTGAATCGAGCTGAGAGGGCTTCCCCGGTTCTCCTGGGAACCCCATCGGCCCCCTGCCAGCACACACCTGAG CAGCATCACAGGACATGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGA CCTTCCCAGGAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGG GTGGGGGCTCCAGGAGACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCT GGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGC TTGGCATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCC CCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAG CCAACAAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAA TTCGAGACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGA GCGAGCTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACC GCAACGGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGA AGCTTCCGGGGGGCCTGGAGCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACAGCTTTCGAGAGTGAGGCCTGCCAGCAGGCCAGG GACTCAGCGTCCCCTGCTACTCCTGTGCTCTGGAGGCTGCAGAGCTGACCCAGAGTGGAGTCTGAGTCTGAGTCCTGTCTCTGCCTGCGG CCCAGAAGTTTCCCTCAAATGCGCGTGTGCACGTGTGCGTGTGCGTGCGTGTGTGTGTGTTTGTGAGCATGGGTGTGCCCTTGGGGTAAG CCAGAGCCTGGGGTGTTCTCTTTGGTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGGTCTGAGCCCTGGTGTGTTT CCAGATCGATCCTGGATTCACTCACTCACTCATTCCTTCACTCATCCAGCCACCTAAAAACATTTACTGACCATGTACTACGTGCCAGCT CTAGTTTTCAGCCTTGGGAGGTTTTATTCTGACTTCCTCTGATTTTGGCATGTGGAGACACTCCTATAAGGAGAGTTCAAGCCTGTGGGA >In-frame_RARA_ENST00000254066_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_2209nt CAGAAGCAGGGGGGAATCCTGAATCGAGCTGAGAGGGCTTCCCCGGTTCTCCTGGGAACCCCATCGGCCCCCTGCCAGCACACACCTGAG CAGCATCACAGGACATGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGA CCTTCCCAGGAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGG GTGGGGGCTCCAGGAGACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCT GGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGC TTGGCATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCC CCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAG CCAACAAGGACGAGGGTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAA TTCGAGACCGGAGCACCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGA GCGAGCTGCACCGGGCGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACC GCAACGGCAACTTCCACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGA AGCTTCCGGGGGGCCTGGAGCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACAGCTTTCGAGAGTGAGGCCTGCCAGCAGGCCAGG GACTCAGCGTCCCCTGCTACTCCTGTGCTCTGGAGGCTGCAGAGCTGACCCAGAGTGGAGTCTGAGTCTGAGTCCTGTCTCTGCCTGCGG CCCAGAAGTTTCCCTCAAATGCGCGTGTGCACGTGTGCGTGTGCGTGCGTGTGTGTGTGTTTGTGAGCATGGGTGTGCCCTTGGGGTAAG CCAGAGCCTGGGGTGTTCTCTTTGGTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGGTCTGAGCCCTGGTGTGTTT CCAGATCGATCCTGGATTCACTCACTCACTCATTCCTTCACTCATCCAGCCACCTAAAAACATTTACTGACCATGTACTACGTGCCAGCT CTAGTTTTCAGCCTTGGGAGGTTTTATTCTGACTTCCTCTGATTTTGGCATGTGGAGACACTCCTATAAGGAGAGTTCAAGCCTGTGGGA GTAGAAAAATCTCATTCCCAGAGTCAGAGGAGAAGAGACATGTACCTTGACCATCGTCCTTCCTCTCAAGCTAGCCAGAGGGTGGGAGCC TAAGGAAGCGTGGGGTAGCAGATGGAGTAATGGTCACGAGGTCCAGACCCACTCCCAAAGCTCAGACTTGCCAGGCTCCCTTTCTCTTCT TCCCCAGGTCCTTCCTTTAGGTCTGGTTGTTGCACCATCTGCTTGGTTGGCTGGCAGCTGAGAGCCCTGCTGTGGGAGAGCGAAGGGGGT CAAAGGAAGACTTGAAGCACAGAGGGCTAGGGAGGTGGGGTACATTTCTCTGAGCAGTCAGGGTGGGAAGAAAGAATGCAAGAGTGGACT GAATGTGCCTAATGGAGAAGACCCACGTGCTAGGGGATGAGGGGCTTCCTGGGTCCTGTTCCCTACCCCATTTGTGGTCACAGCCATGAA GTCACCGGGATGAACCTATCCTTCCAGTGGCTCGCTCCCTGTAGCTCTGCCTCCCTCTCCATATCTCCTTCCCCTACACCTCCCTCCCCA CACCTCCCTACTCCCCTGGGCATCTTCTGGCTTGACTGGATGGAAGGAGACTTAGGAACCTACCAGTTGGCCATGATGTCTTTTCTTCTT >In-frame_RARA_ENST00000394089_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_1636nt GTGACTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCC GAGCAGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACA TGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAG TGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGA GACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCAT GCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCA ACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTG GACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAACAAGGACGAGG GTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGAGACCGGAGCA CCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAGCTGCACCGGG CGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAACGGCAACTTCC ACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTTCCGGGGGGCC TGGAGCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACAGCTTTCGAGAGTGAGGCCTGCCAGCAGGCCAGGGACTCAGCGTCCCCT GCTACTCCTGTGCTCTGGAGGCTGCAGAGCTGACCCAGAGTGGAGTCTGAGTCTGAGTCCTGTCTCTGCCTGCGGCCCAGAAGTTTCCCT CAAATGCGCGTGTGCACGTGTGCGTGTGCGTGCGTGTGTGTGTGTTTGTGAGCATGGGTGTGCCCTTGGGGTAAGCCAGAGCCTGGGGTG TTCTCTTTGGTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGGTCTGAGCCCTGGTGTGTTTCCAGATCGATCCTGG ATTCACTCACTCACTCATTCCTTCACTCATCCAGCCACCTAAAAACATTTACTGACCATGTACTACGTGCCAGCTCTAGTTTTCAGCCTT GGGAGGTTTTATTCTGACTTCCTCTGATTTTGGCATGTGGAGACACTCCTATAAGGAGAGTTCAAGCCTGTGGGAGTAGAAAAATCTCAT >In-frame_RARA_ENST00000394089_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_2284nt GTGACTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCC GAGCAGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACA TGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAG TGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGA GACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCAT GCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCA ACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTG GACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAACAAGGACGAGG GTGACCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGAGACCGGAGCA CCAGTGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAGCTGCACCGGG CGCTGGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAACGGCAACTTCC ACCCCAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTTCCGGGGGGCC TGGAGCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACAGCTTTCGAGAGTGAGGCCTGCCAGCAGGCCAGGGACTCAGCGTCCCCT GCTACTCCTGTGCTCTGGAGGCTGCAGAGCTGACCCAGAGTGGAGTCTGAGTCTGAGTCCTGTCTCTGCCTGCGGCCCAGAAGTTTCCCT CAAATGCGCGTGTGCACGTGTGCGTGTGCGTGCGTGTGTGTGTGTTTGTGAGCATGGGTGTGCCCTTGGGGTAAGCCAGAGCCTGGGGTG TTCTCTTTGGTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGGTCTGAGCCCTGGTGTGTTTCCAGATCGATCCTGG ATTCACTCACTCACTCATTCCTTCACTCATCCAGCCACCTAAAAACATTTACTGACCATGTACTACGTGCCAGCTCTAGTTTTCAGCCTT GGGAGGTTTTATTCTGACTTCCTCTGATTTTGGCATGTGGAGACACTCCTATAAGGAGAGTTCAAGCCTGTGGGAGTAGAAAAATCTCAT TCCCAGAGTCAGAGGAGAAGAGACATGTACCTTGACCATCGTCCTTCCTCTCAAGCTAGCCAGAGGGTGGGAGCCTAAGGAAGCGTGGGG TAGCAGATGGAGTAATGGTCACGAGGTCCAGACCCACTCCCAAAGCTCAGACTTGCCAGGCTCCCTTTCTCTTCTTCCCCAGGTCCTTCC TTTAGGTCTGGTTGTTGCACCATCTGCTTGGTTGGCTGGCAGCTGAGAGCCCTGCTGTGGGAGAGCGAAGGGGGTCAAAGGAAGACTTGA AGCACAGAGGGCTAGGGAGGTGGGGTACATTTCTCTGAGCAGTCAGGGTGGGAAGAAAGAATGCAAGAGTGGACTGAATGTGCCTAATGG AGAAGACCCACGTGCTAGGGGATGAGGGGCTTCCTGGGTCCTGTTCCCTACCCCATTTGTGGTCACAGCCATGAAGTCACCGGGATGAAC CTATCCTTCCAGTGGCTCGCTCCCTGTAGCTCTGCCTCCCTCTCCATATCTCCTTCCCCTACACCTCCCTCCCCACACCTCCCTACTCCC CTGGGCATCTTCTGGCTTGACTGGATGGAAGGAGACTTAGGAACCTACCAGTTGGCCATGATGTCTTTTCTTCTTTTTCTTTTTTTTAAC >In-frame_RARA_ENST00000425707_chr17_38487648_+_IGFBP4_ENST00000542955_chr17_38609237_+_1632nt CTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCCGAGC AGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACATGGC CCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAGTGCC AGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGAGACT GAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCATGCCC CGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCAACAG CAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACT CTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAACAAGGACGAGGGTGA CCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGAGACCGGAGCACCAG TGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAGCTGCACCGGGCGCT GGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAACGGCAACTTCCACCC CAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTTCCGGGGGGCCTGGA GCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACAGCTTTCGAGAGTGAGGCCTGCCAGCAGGCCAGGGACTCAGCGTCCCCTGCTA CTCCTGTGCTCTGGAGGCTGCAGAGCTGACCCAGAGTGGAGTCTGAGTCTGAGTCCTGTCTCTGCCTGCGGCCCAGAAGTTTCCCTCAAA TGCGCGTGTGCACGTGTGCGTGTGCGTGCGTGTGTGTGTGTTTGTGAGCATGGGTGTGCCCTTGGGGTAAGCCAGAGCCTGGGGTGTTCT CTTTGGTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGGTCTGAGCCCTGGTGTGTTTCCAGATCGATCCTGGATTC ACTCACTCACTCATTCCTTCACTCATCCAGCCACCTAAAAACATTTACTGACCATGTACTACGTGCCAGCTCTAGTTTTCAGCCTTGGGA GGTTTTATTCTGACTTCCTCTGATTTTGGCATGTGGAGACACTCCTATAAGGAGAGTTCAAGCCTGTGGGAGTAGAAAAATCTCATTCCC >In-frame_RARA_ENST00000425707_chr17_38487648_+_IGFBP4_ENST00000269593_chr17_38609237_+_2280nt CTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCCGAGC AGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACATGGC CCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAGTGCC AGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGAGACT GAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCATGCCC CGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCAACAG CAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACT CTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAACAAGGACGAGGGTGA CCACCCCAACAACAGCTTCAGCCCCTGTAGCGCCCATGACCGCAGGTGCCTGCAGAAGCACTTCGCCAAAATTCGAGACCGGAGCACCAG TGGGGGCAAGATGAAGGTCAATGGGGCGCCCCGGGAGGATGCCCGGCCTGTGCCCCAGGGCTCCTGCCAGAGCGAGCTGCACCGGGCGCT GGAGCGGCTGGCCGCTTCACAGAGCCGCACCCACGAGGACCTCTACATCATCCCCATCCCCAACTGCGACCGCAACGGCAACTTCCACCC CAAGCAGTGTCACCCAGCTCTGGATGGGCAGCGTGGCAAGTGCTGGTGTGTGGACCGGAAGACGGGGGTGAAGCTTCCGGGGGGCCTGGA GCCAAAGGGGGAGCTGGACTGCCACCAGCTGGCTGACAGCTTTCGAGAGTGAGGCCTGCCAGCAGGCCAGGGACTCAGCGTCCCCTGCTA CTCCTGTGCTCTGGAGGCTGCAGAGCTGACCCAGAGTGGAGTCTGAGTCTGAGTCCTGTCTCTGCCTGCGGCCCAGAAGTTTCCCTCAAA TGCGCGTGTGCACGTGTGCGTGTGCGTGCGTGTGTGTGTGTTTGTGAGCATGGGTGTGCCCTTGGGGTAAGCCAGAGCCTGGGGTGTTCT CTTTGGTGTTACACAGCCCAAGAGGACTGAGACTGGCACTTAGCCCAAGAGGTCTGAGCCCTGGTGTGTTTCCAGATCGATCCTGGATTC ACTCACTCACTCATTCCTTCACTCATCCAGCCACCTAAAAACATTTACTGACCATGTACTACGTGCCAGCTCTAGTTTTCAGCCTTGGGA GGTTTTATTCTGACTTCCTCTGATTTTGGCATGTGGAGACACTCCTATAAGGAGAGTTCAAGCCTGTGGGAGTAGAAAAATCTCATTCCC AGAGTCAGAGGAGAAGAGACATGTACCTTGACCATCGTCCTTCCTCTCAAGCTAGCCAGAGGGTGGGAGCCTAAGGAAGCGTGGGGTAGC AGATGGAGTAATGGTCACGAGGTCCAGACCCACTCCCAAAGCTCAGACTTGCCAGGCTCCCTTTCTCTTCTTCCCCAGGTCCTTCCTTTA GGTCTGGTTGTTGCACCATCTGCTTGGTTGGCTGGCAGCTGAGAGCCCTGCTGTGGGAGAGCGAAGGGGGTCAAAGGAAGACTTGAAGCA CAGAGGGCTAGGGAGGTGGGGTACATTTCTCTGAGCAGTCAGGGTGGGAAGAAAGAATGCAAGAGTGGACTGAATGTGCCTAATGGAGAA GACCCACGTGCTAGGGGATGAGGGGCTTCCTGGGTCCTGTTCCCTACCCCATTTGTGGTCACAGCCATGAAGTCACCGGGATGAACCTAT CCTTCCAGTGGCTCGCTCCCTGTAGCTCTGCCTCCCTCTCCATATCTCCTTCCCCTACACCTCCCTCCCCACACCTCCCTACTCCCCTGG GCATCTTCTGGCTTGACTGGATGGAAGGAGACTTAGGAACCTACCAGTTGGCCATGATGTCTTTTCTTCTTTTTCTTTTTTTTAACAAAA |
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FusionGenePPI for RARA_IGFBP4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RARA | NRBF2, ZBTB16, MECR, RXRG, RXRB, NCOA6, GADD45G, GADD45A, NRIP1, KAT2B, HDAC3, HDAC4, TDG, PML, TRIP4, KDM5A, RXRA, POU2F1, NCOR2, NR0B2, BAG1, TADA3, NCOR1, NKX2-1, TRIM24, IRX4, SP1, NPAS2, CLOCK, ARNTL, NR2E3, CCND3, NCOA2, SRC, AJUBA, LIMD1, WTIP, SKI, HR, PIN1, SUV39H1, PSMC5, EP300, PARP1, MED6, TOP2B, SAP130, HNRNPU, RFC4, NPM1, MRTO4, SNRNP40, MED1, NCOA1, HMGA1, RUVBL1, RUNX1, SIAH1, RARA, HDAC2, NCOA3, CREBBP, LRIF1, KLF5, SMARCD3, ARID1A, SPI1, PRDX6, NR1H2, ITGB1BP2, MED25, MAPK6, FOXO1, MAPK1, TRIM32, PHF8, TNIP1, HACE1, SQSTM1, UBQLN1, ARID5A, UBE3A, PRAM1, FAS, PRAME, TBL1XR1, SUZ12, EZH2, USP7, TMEM54, MMS19, AKT1, FN1, WWOX, E2F1, MBD3, MTA2, CBX5, CEBPA, HDAC1, NSD1, TEKT4, SNW1, SIRT1, ACTN4, SRF, MDM2, ZNF131, RARG, RARB, TRIM25 | IGFBP4 | IGF1, IGF2, KDM1A, SUV39H1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RARA_IGFBP4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | RARA | P10276 | DB00210 | Adapalene | Retinoic acid receptor alpha | small molecule | approved |
| Hgene | RARA | P10276 | DB00459 | Acitretin | Retinoic acid receptor alpha | small molecule | approved |
| Hgene | RARA | P10276 | DB00982 | Isotretinoin | Retinoic acid receptor alpha | small molecule | approved |
| Hgene | RARA | P10276 | DB00523 | Alitretinoin | Retinoic acid receptor alpha | small molecule | approved|investigational |
| Hgene | RARA | P10276 | DB00799 | Tazarotene | Retinoic acid receptor alpha | small molecule | approved|investigational |
| Hgene | RARA | P10276 | DB00755 | Tretinoin | Retinoic acid receptor alpha | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for RARA_IGFBP4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RARA | C0023487 | Acute Promyelocytic Leukemia | 22 | CTD_human;HPO;ORPHANET |
| Hgene | RARA | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | RARA | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | RARA | C0010701 | Phyllodes Tumor | 1 | CTD_human |
| Hgene | RARA | C0085183 | Neoplasms, Second Primary | 1 | CTD_human |
| Hgene | RARA | C0149940 | Sciatic Neuropathy | 1 | CTD_human |
| Hgene | RARA | C0206650 | Fibroadenoma | 1 | CTD_human |
| Hgene | RARA | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | RARA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | RARA | C2239176 | Liver carcinoma | 1 | CTD_human |
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