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Fusion gene ID: 30426 |
FusionGeneSummary for RAPGEF1_SEC16A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAPGEF1_SEC16A | Fusion gene ID: 30426 | Hgene | Tgene | Gene symbol | RAPGEF1 | SEC16A | Gene ID | 2889 | 9919 |
| Gene name | Rap guanine nucleotide exchange factor 1 | SEC16 homolog A, endoplasmic reticulum export factor | |
| Synonyms | C3G|GRF2 | KIAA0310|SEC16L|p250 | |
| Cytomap | 9q34.13 | 9q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rap guanine nucleotide exchange factor 1CRK SH3-binding GNRPRap guanine nucleotide exchange factor (GEF) 1guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene) | protein transport protein Sec16Aprotein SEC16 homolog A | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q13905 | O15027 | |
| Ensembl transtripts involved in fusion gene | ENST00000372189, ENST00000372195, ENST00000372190, ENST00000481260, | ENST00000313050, ENST00000467838, ENST00000371706, ENST00000313084, ENST00000290037, ENST00000431893, ENST00000398335, | |
| Fusion gene scores | * DoF score | 17 X 14 X 10=2380 | 4 X 4 X 4=64 |
| # samples | 21 | 4 | |
| ** MAII score | log2(21/2380*10)=-3.50250034052918 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAPGEF1 [Title/Abstract] AND SEC16A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAPGEF1 | GO:0038180 | nerve growth factor signaling pathway | 17724123 |
| Hgene | RAPGEF1 | GO:0043547 | positive regulation of GTPase activity | 10548487 |
| Hgene | RAPGEF1 | GO:0071320 | cellular response to cAMP | 21840392 |
| Hgene | RAPGEF1 | GO:1990090 | cellular response to nerve growth factor stimulus | 17724123 |
| Tgene | SEC16A | GO:0007029 | endoplasmic reticulum organization | 21768384 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-HT-7483-01A | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000372189 | ENST00000313050 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372189 | ENST00000467838 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372189 | ENST00000371706 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372189 | ENST00000313084 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372189 | ENST00000290037 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372189 | ENST00000431893 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372189 | ENST00000398335 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| In-frame | ENST00000372195 | ENST00000313050 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| 5CDS-intron | ENST00000372195 | ENST00000467838 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| 5CDS-intron | ENST00000372195 | ENST00000371706 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| 5CDS-intron | ENST00000372195 | ENST00000313084 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| 5CDS-intron | ENST00000372195 | ENST00000290037 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| 5CDS-intron | ENST00000372195 | ENST00000431893 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| 5CDS-intron | ENST00000372195 | ENST00000398335 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-3CDS | ENST00000372190 | ENST00000313050 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372190 | ENST00000467838 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372190 | ENST00000371706 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372190 | ENST00000313084 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372190 | ENST00000290037 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372190 | ENST00000431893 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000372190 | ENST00000398335 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-3CDS | ENST00000481260 | ENST00000313050 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000481260 | ENST00000467838 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000481260 | ENST00000371706 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000481260 | ENST00000313084 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000481260 | ENST00000290037 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000481260 | ENST00000431893 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
| intron-intron | ENST00000481260 | ENST00000398335 | RAPGEF1 | chr9 | 134615157 | - | SEC16A | chr9 | 139372136 | - |
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FusionProtFeatures for RAPGEF1_SEC16A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAPGEF1 | SEC16A |
| Guanine nucleotide-releasing protein that binds to SH3domain of CRK and GRB2/ASH. Transduces signals from CRK toactivate RAS. Plays a role in the establishment of basalendothelial barrier function. Plays a role in nerve growth factor(NGF)-induced sustained activation of Rap1 and neurite outgrowth.{ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392,ECO:0000269|PubMed:7806500}. | Defines endoplasmic reticulum exit sites (ERES) and isrequired for secretory cargo traffic from the endoplasmicreticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly ofSEC16A on the ER membrane forms an organized scaffold defining anERES. Required for normal transitional endoplasmic reticulum (tER)organization. {ECO:0000269|PubMed:17005010,ECO:0000269|PubMed:17192411}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAPGEF1_SEC16A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAPGEF1_ENST00000372195_chr9_134615157_-_SEC16A_ENST00000313050_chr9_139372136_-_20aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAPGEF1_ENST00000372195_chr9_134615157_-_SEC16A_ENST00000313050_chr9_139372136_-_61nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAPGEF1_ENST00000372195_chr9_134615157_-_SEC16A_ENST00000313050_chr9_139372136_-_9111nt CGCTGCGCTGCGGCCGGCTCGCGGGCCGGGGGAGCGGCGGCGGGCGCGCGGGAGGCGGAGCGGCGGCGGCGGGCGCGGCGGGAGCGGCTG GGCCCGGGCGGGCTGGAGCGCGGTCGCCGAGCGCAGGGCCGCGGCCGCGCGGAGCCCGCCATGCCGGCGCGGGTCTGAGGCGTGGCGAGC CAGGGCCGAGGCGAGCGGCGGGCGCGCCGCCCCTGTCGCCCCGCGGCGGCCCGGCCCGGGCCCGATGAGCGGCGGCCTCGGCCTCCGGCG CAGCCCGGAAATGTCCGGCAAGATCGAGAAAGCAGTCCAGCTCCAATTAAGGAACAGCTATATCCTGCTTCCTTCTGTAAGCAGCATCGA CTTGTGCAAGGGTTCAGTCATGCAGCCACCGCCCCAGACGGTCCCGTCTGGCATGGCTGGGCCACCTCCAGCCGGGAATCCTCGGAGCGT GTTCTGGGCTAGCAGCCCTTACAGGAGACGGGCTAATAATAATGCAGCAGTGGCTCCGACAACTTGCCCGTTGCAGCCGGTCACGGATCC ATTTGCTTTTAGTAGACAGGCGCTCCAAAGTACACCACTGGGCAGTTCGTCCAAAAGCAGTCCACCTGTCTTGCAAGGCCCAGCCCCCGC AGGGTTTTCTCAGCACCCCGGTTTGCTTGTTCCTCACACACATGCCAGAGATAGCTCTCAGGGACCCTGTGAGCCCCTGCCTGGACCTCT GACACAGCCCAGAGCACATGCCAGTCCGTTTTCTGGTGCATTGACACCTTCAGCACCTCCTGGGCCTGAGATGAACAGGAGTGCAGAGGT CGGTCCCAGTTCAGAGCCTGAAGTTCAGACTCTGCCATATCTTCCTCACTACATTCCAGGAGTGGATCCTGAAACGTCTCATGGGGGCCA CCCTCATGGGAACATGCCTGGGCTCGACCGACCCCTGAGCAGGCAAAACCCACATGACGGTGTGGTCACCCCAGCAGCATCCCCTTCCCT CCCTCAGCCTGGTCTGCAGATGCCAGGACAGTGGGGGCCAGTGCAGGGAGGCCCACAGCCCTCGGGGCAACATCGTTCACCCTGCCCTGA AGGACCTGTTCCCAGCGGGGTGCCCTGTGCCACCAGCGTTCCTCATTTCCCCACCCCGTCCATCCTACATCAGGGCCCTGGTCATGAGCA ACACAGCCCTCTGGTGGCTCCCCCAGCAGCCTTGCCCAGTGACGGAAGAGACGAGGTGAGCCACTTGCAAAGTGGAAGCCACCTGGCCAA TAACTCTGATCCTGAAAGTACATTCAGGCAAAATCCCAGAATTGTGAATCACTGGGCAAGCCCAGAGCTCAGGCAGAATCCAGGAGTGAA GAATGAGCACCGGCCCGCCTCTGCTCTTGTGAACCCCCTCGCCCGGGGAGATAGCCCAGAAAACCGTACGCACCACCCACTGGGGGCTGG GGCCGGGTCTGGCTGTGCCCCGCTAGAAGCAGACTCAGGAGCTTCAGGAGCTCTGGCGATGTTTTTCCAAGGGGGAGAGACAGAAAATGA GGAGAATCTCTCATCTGAAAAAGCAGGCTTATCTGGTCAAGCGGACTTTGACGATTTCTGCTCCAGCCCTGGGCTAGGCCGTCCGCCCGC ACCTACACACGTGGGGGCAGGCAGCCTCTGCCAGGCCCTTCTCCCAGGCCCCAGCAATGAGGCTGCTGGTGATGTGTGGGGTGACACAGC GAGCACAGGGGTGCCGGATGCCAGCGGCTCGCAGTATGAGAATGTTGAGAACTTAGAATTTGTTCAGAATCAAGAAGTTCTGCCAAGTGA GCCCCTCAATTTGGACCCTTCCTCCCCGAGTGACCAGTTCAGATATGGGCCCCTTCCTGGGCCAGCTGTGCCCAGGCATGGTGCTGTGTG CCACACCGGAGCCCCTGATGCCACACTGCATACAGTGCACCCTGACAGCGTGTCATCCAGCTATAGCAGCAGAAGCCACGGAAGGCTCTC AGGCTCAGCCAGGCCCCAGGAGCTGGTTGGCACATTCATTCAGCAAGAAGTTGGAAAACCCGAGGATGAAGCTTCAGGTAGTTTTTTTAA GCAAATCGATTCTTCTCCCGTAGGAGGTGAAACAGACGAGACCACTGTGAGCCAGAATTACCGTGGCAGCGTGTCCCAGCCCTCAACCCC GAGCCCCCCGAAACCTACAGGAATATTTCAGACAAGTGCAAATAGTTCTTTCGAACCGGTAAAATCTCACTTAGTTGGGGTAAAACCATT TGAGGCAGATCGCGCCAACGTGGTTGGTGAAGTAAGGGAGACCTGTGTCCGCCAGAAGCAGTGCAGACCAGCTGCCGCCCTGCCCGATGC TTCCCCTGGCAACCTGGAGCAGCCACCAGACAACATGGAGACCCTCTGTGCACCCCAGGTCTGTCCCCTGCCTCTTAACTCCACCACGGA AGCTGTGCACATGCTTCCGCACGCAGGGGCACCGCCCTTGGATACTGTGTATCCAGCACCCGAGAAGAGGCCTTCAGCCAGGACCCAGGG GCCCGTGAAGTGTGAGAGCCCAGCAACGACTCTGTGGGCGCAAAGTGAGCTGCCAGATTTTGGAGGCAACGTCCTTCTGGCCCCTGCAGC CCCGGCGCTTTATGTGTGTGCAAAACCTCAGCCACCTGTTGTTCAGCCTCCAGAAGAGGCGATGTCCGGGCAGCAGTCACGGAACCCAAG CTCGGCGGCCCCGGTGCAGAGCCGAGGTGGCATTGGTGCTTCTGAGAACCTTGAGAATCCTCCCAAAATGGGAGAGGAGGAGGCCCTTCA GTCCCAGGCGAGTTCTGGTTATGCAAGTTTATTATCCTCACCGCCCACTGAGTCTCTGCAGAATCCTCCAGTCTTGATTGCTCAGCCTGA TCACAGCTATAATCTGGCTCAGCCCATTAACTTTTCTGTGTCCTTATCGAACTCTCATGAGAAGAATCAGTCCTGGAGAGAGGCTTTGGT GGGGGATAGACCTGCAGTCAGCAGTTGGGCTCTCGGTGGTGATTCTGGGGAGAACACTTCTTTGTCTGGGATTCCAACCAGCTCTGTCCT TAGCTTGTCTCTGCCTAGCAGTGTTGCCCAAAGTAATTTTCCACAAGGTTCTGGTGCTTCCGAAATGGTTTCTAATCAGCCTGCTAATTT GCTGGTTCAACCACCATCCCAGCCAGTTCCAGAGAACTTGGTTCCAGAAAGTCAAAAGGATCGTAAGGCAGGAAGTGCTCTTCCCGGATT TGCTAATAGCCCTGCTGGAAGCACAAGTGTGGTGTTAGTTCCACCTGCACACGGCACCCTGGTGCCTGATGGTAATAAGGCAAACCATTC CAGTCATCAGGAAGACACTTACGGAGCCCTAGACTTTACCTTAAGCAGGACTTTGGAAAATCCTGTAAACGTGTACAACCCGTCCCATTC TGACAGCCTCGCTTCTCAGCAAAGTGTTGCCAGTCATCCCAGACAATCTGGGCCTGGGGCGCCTAACCTTGACCGTTTTTATCAGCAGGT CACGAAAGATGCCCAGGGCCAGCCTGGCCTCGAAAGAGCCCAGCAGGAGCTGGTGCCACCCCAGCAACAGGCTTCTCCCCCACAACTACC CAAAGCCATGTTTTCGGAGCTGTCAAATCCAGAAAGTCTGCCCGCACAGGGACAGGCCCAGAACTCAGCACAGTCACCAGCAAGTCTGGT TCTGGTCGACGCGGGTCAGCAGCTGCCCCCTCGGCCTCCTCAGTCCTCTAGCGTGTCTCTGGTGTCCAGTGGCTCCGGCCAGGCAGCTGT GCCGTCAGAGCAGCCGTGGCCACAGCCAGTGCCTGCACTTGCCCCCGGCCCACCGCCTCAGGACCTGGCCGCCTACTACTACTACCGGCC TTTGTACGATGCCTACCAGCCTCAGTACTCTTTGCCGTACCCACCGGAGCCTGGCGCAGCCTCCCTCTATTACCAGGATGTCTACAGCCT CTATGAGCCTCGATACAGGCCCTATGATGGTGCTGCGTCTGCTTACGCCCAGAACTACCGCTATCCCGAGCCCGAGCGGCCCAGCTCCCG AGCCAGCCACTCCTCGGAACGGCCACCTCCCAGGCAAGGATATCCTGAAGGATACTATAGTTCCAAAAGTGGATGGAGCAGTCAGAGCGA TTACTATGCAAGCTATTACTCCAGCCAGTACGATTATGGAGATCCAGGTCACTGGGATCGTTACCACTACAGTGCTAGAGTCAGGGACCC CCGCACCTATGACCGGAGGTATTGGTGTGATGCAGAGTATGACGCATACAGGAGAGAGCACTCTGCCTTCGGGGACAGGCCCGAGAAACG TGACAACAACTGGAGGTACGATCCTCGCTTCACGGGGAGTTTTGACGATGACCCCGATCCGCACAGAGACCCTTATGGGGAAGAGGTGGA CCGGCGCAGCGTCCACAGCGAGCACTCGGCACGGAGCCTGCACAGCGCACACAGCCTGGCCAGCCGCCGCAGCAGCCTCAGCTCCCACTC GCACCAGAGTCAGATTTACAGAAGCCACAATGTGGCTGCCGGTTCCTACGAGGCCCCGCTTCCTCCAGGCTCCTTTCACGGCGATTTTGC CTACGGCACCTACCGCAGCAATTTCAGCAGTGGCCCCGGCTTCCCAGAGTATGGCTACCCTGCCGACACCGTCTGGCCTGCCATGGAGCA AGTTTCATCAAGACCAACTTCTCCTGAAAAATTTTCAGTGCCTCATGTCTGTGCCAGGTTTGGCCCTGGCGGTCAGCTTATCAAAGTGAT TCCCAATCTGCCTTCAGAAGGACAGCCGGCCTTGGTGGAGGTCCACAGCATGGAGGCCTTGCTGCAGCACACGTCTGAGCAGGAGGAGAT GCGGGCGTTCCCGGGACCCCTGGCCAAAGACGACACCCATAAGGTGGATGTCATTAATTTTGCACAGAACAAAGCTATGAAATGTTTGCA GAATGAAAACTTAATTGACAAAGAGTCTGCAAGTCTTCTTTGGAATTTTATTGTTCTCTTATGCAGACAAAATGGGACCGTGGTAGGGAC CGACATTGCGGAGCTTCTGTTACGAGACCACAGAACAGTGTGGCTTCCTGGGAAGTCGCCCAATGAAGCAAACCTGATTGATTTCACGAA TGAGGCAGTGGAGCAGGTGGAAGAGGAGGAGTCTGGTGAGGCCCAGCTCTCTTTCCTCACTGGTGGTCCGGCGGCTGCCGCCAGCTCGCT CGAGAGAGAGACCGAGAGGTTCAGGGAGCTGTTGCTGTATGGCCGTAAGAAGGATGCTTTGGAGTCTGCAATGAAGAATGGCCTGTGGGG TCACGCTCTGCTACTTGCAAGTAAGATGGACAGCCGGACACACGCCCGAGTCATGACCAGGTTTGCTAACAGCCTCCCAATCAACGACCC TCTGCAGACAGTCTACCAGCTCATGTCCGGACGGATGCCTGCCGCGTCCACGTGCTGTGGAGACGAGAAATGGGGAGATTGGAGGCCGCA CCTCGCCATGGTCTTGTCCAACTTGAACAACAACATGGACGTCGAGTCCAGGACGATGGCTACCATGGGCGACACTCTGGCTTCAAGGGG CCTCTTGGATGCGGCCCACTTCTGCTACCTCATGGCCCAGGCGGGATTTGGTGTTTACACGAAGAAAACTACAAAGCTTGTCTTAATCGG ATCCAATCACAGTTTGCCATTCTTAAAGTTCGCAACCAACGAAGCAATCCAGAGGACGGAAGCCTATGAGTACGCCCAGTCCCTGGGTGC CGAGACCTGCCCCCTGCCTAGTTTCCAGGTGTTTAAGTTCATCTACTCCTGCCGCCTGGCGGAAATGGGGCTGGCCACGCAAGCCTTCCA CTACTGTGAGGCCATCGCGAAGAGCATCCTGACGCAGCCGCACCTGTATTCCCCGGTGTTGATCAGCCAGCTTGTGCAGATGGCTTCCCA GTTACGACTCTTCGATCCCCAGCTGAAAGAGAAGCCAGAAGAGGAGTCCTTGGCCGCACCCACGTGGCTGGTTCACCTGCAGCAGGTGGA GCGGCAGATTAAGGAGGGGGCTGGAGTATGGCATCAGGATGGAGCCCTCCCGCAGCAGTGTCCTGGCACTCCGAGTTCCGAGATGGAGCA GTTGGACAGGCCAGGACTCAGTCAGCCAGGAGCCCTGGGGATCGCCAACCCTCTGCTGGCGGTGCCTGCACCGAGCCCTGAGCACTCGAG CCCGAGCGTGCGGCTGCTGCCCTCAGCTCCGCAGACGCTCCCTGACGGCCCATTGGCCAGTCCTGCCAGAGTGCCGATGTTCCCAGTGCC ACTGCCCCCGGGGCCCCTGGAGCCGGGTCCTGGCTGTGTGACCCCAGGGCCTGCACTTGGCTTCCTGGAGCCCTCCGGGCCTGGCCTCCC ACCTGGTGTGCCACCTCTGCAGGAAAGGAGACACTTGCTCCAGGAAGCCAGGAGCCCAGACCCAGGGATAGTGCCGCAGGAGGCGCCTGT TGGAAACTCACTTTCCGAGCTAAGCGAAGAAAATTTTGATGGAAAATTTGCTAATCTGACCCCCTCGAGGACGGTGCCAGACTCGGAGGC CCCCCCAGGGTGGGATCGTGCCGACTCGGGTCCCACGCAGCCACCTCTGTCTCTCTCACCCGCTCCCGAAACAAAGAGACCCGGACAGGC AGCCAAGAAAGAAACGAAGGAACCTAAGAAGGGTGAATCCTGGTTCTTTCGTTGGCTACCTGGAAAGAAAAAGACAGAAGCTTATTTGCC AGATGACAAGAACAAATCGATTGTTTGGGATGAAAAGAAAAACCAGTGGGTGAATTTAAATGAGCCAGAAGAGGAGAAGAAAGCCCCGCC CCCACCTCCAACCTCGATGCCCAAGACTGTGCAAGCTGCCCCGCCTGCCCTCCCAGGGCCTCCTGGAGCCCCCGTGAACATGTACTCTAG AAGAGCAGCAGGAACCAGAGCTCGCTACGTTGACGTCCTGAACCCAAGCGGGACCCAGCGGAGCGAGCCGGCTCTCGCTCCTGCGGACTT TGTCGCTCCACTCGCGCCACTCCCAATTCCTTCTAACTTGTTCGTGCCAACCCCAGATGCAGAAGAACCACAGCTTCCAGACGGGACTGG CAGGGAAGGGCCTGCAGCAGCTAGGGGCCTGGCCAATCCAGAGCCTGCCCCAGAGCCCAAGGTTTTAAGCTCTGCAGCGTCACTCCCTGG CTCTGAACTCCCCTCCTCCAGGCCTGAGGGTTCCCAGGGAGGAGAGCTTTCGCGCTGTAGTTCAATGAGTTCATTATCACGTGAAGTGAG CCAGCATTTTAATCAGGCTCCTGGCGACCTCCCTGCTGCAGGGGGCCCTCCCAGCGGGGCCATGCCCTTCTACAACCCTGCTCAGCTGGC ACAGGCCTGCGCCACCTCCGGGAGCTCAAGGCTAGGGAGGATTGGCCAGAGGAAGCACCTGGTGCTGAACTAGGCTTGCCCTGCTGTGAA CTTGCACTTGGAGCCCTGACGCTGCTGTTCTCCCCGAAGAACCCGACCGACCTCCGCGATCTCCGTCCCGCCCCCAGGGAGACACAGCAG TGACTCAGAGCTGGTCGCACACTGTGCCTCCCTCCTCACCGCCCATCGTAATGAATTATTTTGAAAATTAATTCCACCATCCTTTCAGAT TCTGGATGGAAAGACTGAATCTTTGACTCAGAATTGTTTGCCGAAAAGAATGATGTGACTTTCTTAGTCATTTAGGATGATTTAAGGATA TAGTATTCCTGGTCATTTAAGAATGTTCATTCATTGAAGCCGGAGCTGTCTCTGCCACAGGAGAGCCACATGGTCGGTAGTAACCAGGGC CTCTCCAAGCCCAGCTGTGAGTCACTGCCCAGTGAGTCCCGCGCTTCCTTTAAGGTGCTGGGAGCAAAGAGAGGGTGACTGAGGCAGACC CCAACCCCTGCTCTGCACCATCTGGGCCCTCGCCGTGTTTGAACCTGGCTGAATGAGTGGAGGGCGCTGTGTTCTCAATCAGCGCCTCCG AGGAGCCGTGGGGTTCCTTCGGCATTAGTTCACGGTTTTTGAGAGAGGCCTTAGTTACTGCAGTGAATTTCTTTCCTGTTGCAAAGACGC TTCCAGCCTCACTTTACTTTCTGTGGCCTGATGAGGACCATGGGTGATTTTGTGTACCCAAAGCGCTGGGGACTGCCCACCGTGTGGCCC AGTCACTGGGAAGGAGCCCCAGAGAGCCGGCTGTCTGACATGATGGCTCAGGGTGGTCATCCAGGTTGAAAACTGACCGTGTGATGTTTG ATTTGGGCTTCATTTCGTGTGTAGGAGCACGGTTAGACTCACTGTTAAGGAAGCTGGATGCACTTCTCTAAAAGGCTGCACTTTCCGTGA GCACTTTTCGTGGTACAATCCACATGACCCACTTTCTCCCCTGGGGGACGTTGGTTCAGAGGTTGGTAGCACTTGGGGAGAGTATCTTAA CACAGTTTCTTGACAGCAGCTCTGGAACTTAGTATTTCTGCCCCGAGTTTTGCCACACTGAGACTTTGAGTAGCTCCTGGTGGACTCAAC CCTGTTCAACTCAGAGACGGGCCTCCTCTCACTGATGCAAAGCTTTAAGGCTTCTCTGACTGTTCTGAAACTCTTCGTATTCTTGTCAAG TCTAAAGAGACTGAAGAAAAGATTTAAATACTAATAAAAATCAGTAGATAATTTCTGTAGGTTCTGCTGGAGGAATACAAACTGTTTGGT GTTTTAAATTTAAGTGTAGAAATTGTAGAATGTGGAATTAGCACAGATCCTTCCTGGCTTTCTGTTTCACTTGATCATTTAGCCCAGACC ACCCAGGATGTTTTCCAAAATGTTCCACAGGCGTGTCCCGCTGGATCCATTTGTCCTTGTCACTTGGAGAAAGGCCAGTCCCTGTGACGG GGCAGCCCTCTCTGTCCCTCGGTCAGCTCGTGTGAATCCTGGGACCTCTTCCGGTCGGCTCTGCCCGCTGTTCTGGGGTCGACTGCCACG ACTTTTGATTCAAGAAGCTTCCTCCAGGCGGGAGCGGCTATTTTTCCTAAATGAGAATTGTTACATTGCAAATTGTTGAATAAAATATTT |
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FusionGenePPI for RAPGEF1_SEC16A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAPGEF1 | BCAR1, HCK, CRKL, NEDD9, GRB2, CRK, SHC1, CBL, ATXN1, MBIP, RPS15, SLC20A1, MOV10, NXF1, ABL1, EGFR, SPATS2L, RAP1A, RAP2B | SEC16A | NFKB2, TERF1, TERF2, SIRT7, TSG101, CUL3, CAND1, SHC1, VCP, IQCB1, TRAF3, USO1, TRAF2, PAN2, SOX2, HDAC6, HDAC8, HDAC11, ANKRD28, LATS1, LATS2, SAV1, FKBP3, KRT18, CSNK1A1, CSNK1E, CEP250, EMD, CCDC8, RNF2, IRAK1, KLK15, AHNAK, HNRNPH3, NTRK1, MED23, CENPJ, XPO1, AP2A1, C4BPA, CAD, CLTA, CLTB, CLTC, DCTN1, DSP, ERF, GAK, GOLGA2, HNRNPA1, HNRNPK, IMPDH1, IMPDH2, HNRNPM, PFDN2, PIK3C2A, PKP2, PRKAR2A, RBM4, ATXN2, SEC13, TRPS1, VCL, ZKSCAN1, CLTCL1, TNK1, HDAC3, FUBP3, P4HA2, MAP7, BAG3, RBM39, NCOR2, SEC24C, CLINT1, PUM1, SMG7, CAPZA2, CDK2, DBN1, MYH9, PPP1CB, PRKAR2B, PICALM, IQGAP1, SYNPO, MAPRE1, TRIM29, LIMA1, GTSE1, MYO19, CDKN2AIPNL, ELMSAN1, ARX, FAM83H, MYO18A, HELZ, SEC24B, RBM14, SEC23B, SEC23A, SEC24A, PPP1R13L, PKP3, BTBD3, SPG20, FAM120A, KANK2, AKAP8L, PLEKHA5, ANKHD1, FAM120C, PIH1D1, WDR33, BMP2K, KIAA1217, EIF4ENIF1, CCAR2, P3H1, CPSF7, FIP1L1, FAM83D, CHD6, PRRC2B, FAM83A, WDR92, HNRNPUL2, FAM83B, CRY2, MCM2, RC3H1, MYO6, EGFR, EYA2, NEFL, XPNPEP3, AIPL1, PDHA1, BRCA1, YAP1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAPGEF1_SEC16A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAPGEF1_SEC16A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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