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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30407

FusionGeneSummary for RAP2B_ANAPC16

check button Fusion gene summary
Fusion gene informationFusion gene name: RAP2B_ANAPC16
Fusion gene ID: 30407
HgeneTgene
Gene symbol

RAP2B

ANAPC16

Gene ID

5912

119504

Gene nameRAP2B, member of RAS oncogene familyanaphase promoting complex subunit 16
Synonyms-APC16|C10orf104|CENP-27|MSAG|bA570G20.3
Cytomap

3q25.2

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rap-2bsmall GTP binding proteinanaphase-promoting complex subunit 16centromere protein 27cyclosome subunit 16metabolic syndrome-associated protein
Modification date2018051920180522
UniProtAcc

P61225

Q96DE5

Ensembl transtripts involved in fusion geneENST00000323534, ENST00000299381, 
ENST00000470481, 
Fusion gene scores* DoF score4 X 4 X 2=328 X 7 X 5=280
# samples 311
** MAII scorelog2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAP2B [Title/Abstract] AND ANAPC16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAP2B

GO:0030168

platelet activation

18582561

HgeneRAP2B

GO:0070527

platelet aggregation

18582561

TgeneANAPC16

GO:0016567

protein ubiquitination

20360068


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-BB-4227-01ARAP2Bchr3

152880846

+ANAPC16chr10

73990124

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323534ENST00000299381RAP2Bchr3

152880846

+ANAPC16chr10

73990124

+
5CDS-3UTRENST00000323534ENST00000470481RAP2Bchr3

152880846

+ANAPC16chr10

73990124

+

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FusionProtFeatures for RAP2B_ANAPC16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAP2B

P61225

ANAPC16

Q96DE5

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR andCHRM3 signaling pathways through stimulation of PLCE1. May play arole in cytoskeletal rearrangements and regulate cell spreadingthrough activation of the effector TNIK. May regulate membranevesiculation in red blood cells. {ECO:0000269|PubMed:11877431,ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}. Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:20360068}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAP2B_ANAPC16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAP2B_ANAPC16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAP2BPDE6D, RUNDC3A, RALGDS, RAPGEF2, MME, FN1, VCAM1, ITGA4, CAMK2B, RASSF5, ABCE1, CCT6A, RIN1, RAPGEF1ANAPC16RBBP6, CDC27, ELAVL1, MDC1, TP53BP1, ANAPC4, CDC20, PENK, BUB3, GRAP2, MAGIX, TTLL1, ANAPC7, ANAPC1, ANAPC5, CDC23, CDC26, CDC16, ANAPC15, CFAP97, USP37, ANAPC13, C16orf87, KIF2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAP2B_ANAPC16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAP2B_ANAPC16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource