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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30395

FusionGeneSummary for RAP1GAP_GLIS3

check button Fusion gene summary
Fusion gene informationFusion gene name: RAP1GAP_GLIS3
Fusion gene ID: 30395
HgeneTgene
Gene symbol

RAP1GAP

GLIS3

Gene ID

5909

169792

Gene nameRAP1 GTPase activating proteinGLIS family zinc finger 3
SynonymsRAP1GA1|RAP1GAP1|RAP1GAPII|RAPGAPNDH|ZNF515
Cytomap

1p36.12

9p24.2

Type of geneprotein-codingprotein-coding
Descriptionrap1 GTPase-activating protein 1zinc finger protein GLIS3GLI-similar 3OK/KNS-cl.4zinc finger protein 515
Modification date2018051920180527
UniProtAcc

P47736

Q8NEA6

Ensembl transtripts involved in fusion geneENST00000374761, ENST00000290101, 
ENST00000374763, ENST00000374765, 
ENST00000542643, ENST00000374757, 
ENST00000381971, ENST00000324333, 
ENST00000461870, 
Fusion gene scores* DoF score6 X 5 X 5=1506 X 6 X 5=180
# samples 76
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAP1GAP [Title/Abstract] AND GLIS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAP1GAP

GO:0043087

regulation of GTPase activity

18309292

HgeneRAP1GAP

GO:0043547

positive regulation of GTPase activity

15141215


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU618568RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000374761ENST00000381971RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-3UTRENST00000374761ENST00000324333RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374761ENST00000461870RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000290101ENST00000381971RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-3UTRENST00000290101ENST00000324333RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000290101ENST00000461870RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374763ENST00000381971RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-3UTRENST00000374763ENST00000324333RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374763ENST00000461870RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374765ENST00000381971RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-3UTRENST00000374765ENST00000324333RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374765ENST00000461870RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000542643ENST00000381971RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-3UTRENST00000542643ENST00000324333RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000542643ENST00000461870RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374757ENST00000381971RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-3UTRENST00000374757ENST00000324333RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+
intron-intronENST00000374757ENST00000461870RAP1GAPchr1

21975850

-GLIS3chr9

3824473

+

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FusionProtFeatures for RAP1GAP_GLIS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAP1GAP

P47736

GLIS3

Q8NEA6

GTPase activator for the nuclear Ras-related regulatoryprotein RAP-1A (KREV-1), converting it to the putatively inactiveGDP-bound state. {ECO:0000269|PubMed:15141215}. Acts as both a repressor and activator of transcription.Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAP1GAP_GLIS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAP1GAP_GLIS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAP1GAP_GLIS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAP1GAP_GLIS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAP1GAPC0025202melanoma2CTD_human
HgeneRAP1GAPC0023487Acute Promyelocytic Leukemia1CTD_human
HgeneRAP1GAPC0030297Pancreatic Neoplasm1CTD_human
HgeneRAP1GAPC0040136Thyroid Neoplasm1CTD_human
TgeneGLIS3C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneGLIS3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneGLIS3C0017605Angle Closure Glaucoma1CTD_human