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Fusion gene ID: 30348 |
FusionGeneSummary for RANBP9_CDKAL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RANBP9_CDKAL1 | Fusion gene ID: 30348 | Hgene | Tgene | Gene symbol | RANBP9 | CDKAL1 | Gene ID | 10048 | 54901 |
| Gene name | RAN binding protein 9 | CDK5 regulatory subunit associated protein 1 like 1 | |
| Synonyms | BPM-L|BPM90|RANBPM|RanBP7 | - | |
| Cytomap | 6p23 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ran-binding protein 9Ran Binding Protein in the Microtubule organizing centernovel centrosomal protein RanBPMran binding protein, centrosomalran-binding protein M | threonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96S59 | Q5VV42 | |
| Ensembl transtripts involved in fusion gene | ENST00000011619, ENST00000469916, ENST00000539980, | ENST00000274695, ENST00000378624, ENST00000378610, ENST00000476517, | |
| Fusion gene scores | * DoF score | 9 X 4 X 4=144 | 11 X 7 X 5=385 |
| # samples | 6 | 11 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/385*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RANBP9 [Title/Abstract] AND CDKAL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A1PF-01A | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000011619 | ENST00000274695 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| Frame-shift | ENST00000011619 | ENST00000378624 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| Frame-shift | ENST00000011619 | ENST00000378610 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| 5CDS-intron | ENST00000011619 | ENST00000476517 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-3CDS | ENST00000469916 | ENST00000274695 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-3CDS | ENST00000469916 | ENST00000378624 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-3CDS | ENST00000469916 | ENST00000378610 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-intron | ENST00000469916 | ENST00000476517 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-3CDS | ENST00000539980 | ENST00000274695 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-3CDS | ENST00000539980 | ENST00000378624 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-3CDS | ENST00000539980 | ENST00000378610 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
| intron-intron | ENST00000539980 | ENST00000476517 | RANBP9 | chr6 | 13697017 | - | CDKAL1 | chr6 | 20955650 | + |
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FusionProtFeatures for RANBP9_CDKAL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RANBP9 | CDKAL1 |
| May act as an adapter protein to couple membranereceptors to intracellular signaling pathways. May be involved insignaling of ITGB2/LFA-1 and other integrins. Enhances HGF-METsignaling by recruiting Sos and activating the Ras pathway.Enhances dihydrotestosterone-induced transactivation activity ofAR, as well as dexamethasone-induced transactivation activity ofNR3C1, but not affect estrogen-induced transactivation. StabilizesTP73 isoform Alpha, probably by inhibiting its ubiquitination, andincreases its proapoptotic activity. Inhibits the kinase activityof DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.{ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945,ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085,ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019,ECO:0000269|PubMed:18222118}. | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position37 in tRNAs that read codons beginning with adenine.{ECO:0000269|PubMed:20584901}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RANBP9_CDKAL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RANBP9_CDKAL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RANBP9 | USP11, AR, S100A7, RNPS1, NR3C1, DYRK1B, DISC1, CALB1, UCHL1, MET, HIPK2, RAN, GID8, MPHOSPH8, MKLN1, USP42, PMS1, AIRE, WNK1, APC, PRKACA, TP73, TRAF6, UBC, NCOR2, NCOA6, PPARD, HNF4G, MAPK6, LLGL1, PPP1CA, ARRB1, SPP1, GRK5, MAEA, RMND5A, RANBP9, DDX1, DYNC1H1, DCTN2, PSMC3, DDB1, DCTN1, EEF1A1, BRCA1, NOTCH1, PPP1CC, SMAD9, SMAD3, SMAD2, SPAG8, SOX2, CLEC7A, LTB4R2, TGFBR1, PSMD13, RPS12, RPS13, RPS27, RPS27L, WDR26, TSR1, UBE2I, CBS, HDAC6, FXR1, LRP1, APP, BACE1, HMBS, ADAP1, ADAP2, ITGB2, CD4, ITGB1, TFRC, THRB, THRA, ESR1, L1CAM, PRKCD, PRKCG, DRD1, NTRK2, ENTPD1, CDK11B, FMR1, COPS5, CACNA1G, AXL, RAF1, OPRM1, TP53, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, MRPL4, HLA-DPB1, PRG2, EPB41L3, UNK, NTRK1, MED4, EXOC2, CCND1, ILK, NAF1, SKI, TUBA1B, NFATC1, NFATC2, ATM, PIGT, PRG3, BMP1, RANBP10, YPEL5, ARMC8, RMND5B, GID4, ZMYND19, DDX5, RAB8A, EFHC2, PRPF31, LMNA | CDKAL1 | ELAVL1, MMS19, LMNA, FAM96B, CIAO1, LCK, SUZ12, TCTN2, TCTN3, EVC2, NEK8, TMEM237, TMEM17, TMEM216, FAF2, TTYH3, BPIFB1, DNM1, TYW3, DNM3, TYW1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANBP9_CDKAL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANBP9_CDKAL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RANBP9 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CDKAL1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | CTD_human |
| Tgene | CDKAL1 | C0005910 | Body Weight | 2 | CTD_human |
| Tgene | CDKAL1 | C0005612 | Birth Weight | 1 | CTD_human |
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