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Fusion gene ID: 30344 |
FusionGeneSummary for RANBP3_PRM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RANBP3_PRM1 | Fusion gene ID: 30344 | Hgene | Tgene | Gene symbol | RANBP3 | PRM1 | Gene ID | 8498 | 137902 |
| Gene name | RAN binding protein 3 | peroxidasin like | |
| Synonyms | - | PMR1|PRM1|VPO2 | |
| Cytomap | 19p13.3 | 8q11.22-q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ran-binding protein 3 | peroxidasin-like proteincardiac peroxidasecardiovascular peroxidase 2peroxidasin homolog-likepolysomal ribonuclease 1 homologvascular peroxidase 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H6Z4 | P04553 | |
| Ensembl transtripts involved in fusion gene | ENST00000439268, ENST00000340578, ENST00000541471, ENST00000591092, ENST00000034275, ENST00000591124, | ENST00000312511, | |
| Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 2 X 1 X 2=4 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: RANBP3 [Title/Abstract] AND PRM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-5856-01A | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000439268 | ENST00000312511 | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
| In-frame | ENST00000340578 | ENST00000312511 | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
| In-frame | ENST00000541471 | ENST00000312511 | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
| In-frame | ENST00000591092 | ENST00000312511 | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
| In-frame | ENST00000034275 | ENST00000312511 | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
| intron-3CDS | ENST00000591124 | ENST00000312511 | RANBP3 | chr19 | 5927979 | - | PRM1 | chr16 | 11375087 | - |
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FusionProtFeatures for RANBP3_PRM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RANBP3 | PRM1 |
| Acts as a cofactor for XPO1/CRM1-mediated nuclearexport, perhaps as export complex scaffolding protein. Bound toXPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In theabsence of Ran-bound GTP prevents binding of XPO1/CRM1 to thenuclear pore complex. Binds to CHC1/RCC1 and increases the guaninenucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 toCHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2and SMAD3, and mediating their nuclear export.{ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268,ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081,ECO:0000269|PubMed:9637251}. | Protamines substitute for histones in the chromatin ofsperm during the haploid phase of spermatogenesis. They compactsperm DNA into a highly condensed, stable and inactive complex. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000034275 | - | 8 | 16 | 76_81 | 203 | 500 | Compositional bias | Note=Poly-Pro |
| Hgene | RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000340578 | - | 9 | 17 | 76_81 | 271 | 568 | Compositional bias | Note=Poly-Pro |
| Hgene | RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000439268 | - | 9 | 17 | 76_81 | 266 | 563 | Compositional bias | Note=Poly-Pro |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000034275 | - | 8 | 16 | 537_543 | 203 | 500 | Compositional bias | Note=Poly-Asp |
| Hgene | >RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000340578 | - | 9 | 17 | 537_543 | 271 | 568 | Compositional bias | Note=Poly-Asp |
| Hgene | >RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000439268 | - | 9 | 17 | 537_543 | 266 | 563 | Compositional bias | Note=Poly-Asp |
| Hgene | >RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000034275 | - | 8 | 16 | 378_518 | 203 | 500 | Domain | RanBD1 |
| Hgene | >RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000340578 | - | 9 | 17 | 378_518 | 271 | 568 | Domain | RanBD1 |
| Hgene | >RANBP3 | chr19:5927979 | chr16:11375087 | ENST00000439268 | - | 9 | 17 | 378_518 | 266 | 563 | Domain | RanBD1 |
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FusionGeneSequence for RANBP3_PRM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RANBP3_ENST00000439268_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_266aa MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR ELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP >In-frame_RANBP3_ENST00000340578_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_271aa MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR ELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP QPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRV >In-frame_RANBP3_ENST00000541471_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_143aa MADLANEEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWR >In-frame_RANBP3_ENST00000591092_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_198aa MADLANEEKPAIAPPVFVFQKDKGQKRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAG LPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEEKEPQKNESSNASEEEACEKKD >In-frame_RANBP3_ENST00000034275_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_203aa MADLANEEKPAIAPPVFVFQKDKGQKRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAG LPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RANBP3_ENST00000439268_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_798nt ATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGTCCCCTGCAGAG CAAAAAAACTTGTCGGATTCGGGAGAGGAGCCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAG CATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCTCCTGAAGCCCAGCTTCCTCCTTTTCCGCGA GAACTGGCAGGGAGGTCAGCTGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAG CGAGAAAGAACATCCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATC CACGGCCAAGCCCCCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCG CAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCA TCCCCTGACACTGCTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAA >In-frame_RANBP3_ENST00000340578_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_813nt ATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGTCCCCTGCAGAG CAAAAAAACTTGTCGGATTCGGGAGAGGAGCCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAG CATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCTCCTGAAGCCCAGCTTCCTCCTTTTCCGCGA GAACTGGCAGGGAGGTCAGCTGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAG CGAGAAAGAACATCCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATC CACGGCCAAGCCCCCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCG CAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCA TCCCCTGACACTGCTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCC AGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTT >In-frame_RANBP3_ENST00000541471_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_429nt ATGGCGGACCTGGCGAACGAAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGT CTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACT GTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGA AGTCCTTCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCC >In-frame_RANBP3_ENST00000591092_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_594nt ATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGAGGTCAGCTGGC GGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTTAACC CAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGT CTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACT GTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGA AGTCCTTCCGAAGCTGCCGATGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGAC >In-frame_RANBP3_ENST00000034275_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_609nt ATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGAGGTCAGCTGGC GGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTTAACC CAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGT CTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACT GTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGA AGTCCTTCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RANBP3_ENST00000439268_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_1120nt CTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGG ATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCA CGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCTCCTG AAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGAGGTCAGCTGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAG ATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCT TCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGC TTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAG ACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGAGAAAGAGCCCCAGA AAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGA GGGACAGAGTTAAGGCAGAGCTGGCCCCTGACTCACAGCCCACAGAGTTCCACCTGCTCACAGGTTGGCTGGCTCAGCCAAGGTGGTGCC CTGCTCTGAGCATTCAGGCCAAGCCCATCCTGCACCATGGCCAGGTACAGATGCTGTCGCAGCCAGAGCCGGAGCAGATATTACCGCCAG AGACAAAGAAGTCGCAGACGAAGGAGGCGGAGCTGCCAGACACGGAGGAGAGCCATGAAGCCAGAGCCTTTTAAGTCCATCATCTGGATA >In-frame_RANBP3_ENST00000340578_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_1167nt AGAAAGCAGGCGAGCCTGGGCCGGCGCGGGGCCTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGC CATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCC TCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGC CTCAGCCAGCACTCCTCCGCCTCCCGCTCCTGAAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGAGGTCAGCTGGCGGCTCCAG TCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTTAACCCAGTTCCC ACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCAAG CCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACTGTCCCCAG CAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCTTC CGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAA AAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGGCAGAGCTGGCCCCTGACTCACAGCCCAC AGAGTTCCACCTGCTCACAGGTTGGCTGGCTCAGCCAAGGTGGTGCCCTGCTCTGAGCATTCAGGCCAAGCCCATCCTGCACCATGGCCA GGTACAGATGCTGTCGCAGCCAGAGCCGGAGCAGATATTACCGCCAGAGACAAAGAAGTCGCAGACGAAGGAGGCGGAGCTGCCAGACAC >In-frame_RANBP3_ENST00000541471_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_783nt AGAAAGCAGGCGAGCCTGGGCCGGCGCGGGGCCTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAGGAAAGGAG CAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCG GAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCT CCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGTGTGTGC ACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGC CTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGGCAGAGCTGGCCCCTGACTCACAGCCCACAGAGTTCCACCTGCTCACAGGTTG GCTGGCTCAGCCAAGGTGGTGCCCTGCTCTGAGCATTCAGGCCAAGCCCATCCTGCACCATGGCCAGGTACAGATGCTGTCGCAGCCAGA GCCGGAGCAGATATTACCGCCAGAGACAAAGAAGTCGCAGACGAAGGAGGCGGAGCTGCCAGACACGGAGGAGAGCCATGAAGCCAGAGC >In-frame_RANBP3_ENST00000591092_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_901nt AAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGA GGTCAGCTGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACAT CCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCC CCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGC TGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTG CTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTG AGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGGCAGAGCTGGCCCCTGACTCACAGC CCACAGAGTTCCACCTGCTCACAGGTTGGCTGGCTCAGCCAAGGTGGTGCCCTGCTCTGAGCATTCAGGCCAAGCCCATCCTGCACCATG GCCAGGTACAGATGCTGTCGCAGCCAGAGCCGGAGCAGATATTACCGCCAGAGACAAAGAAGTCGCAGACGAAGGAGGCGGAGCTGCCAG ACACGGAGGAGAGCCATGAAGCCAGAGCCTTTTAAGTCCATCATCTGGATACATGCCCATGAACCAGGGTAATCTTGGGGAGTCTTGCCA >In-frame_RANBP3_ENST00000034275_chr19_5927979_-_PRM1_ENST00000312511_chr16_11375087_-_909nt TAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGAGGTCAGC TGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTT AACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGC AGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCA GACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATG GAGAAGTCCTTCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGA AGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGGCAGAGCTGGCCCCTGA CTCACAGCCCACAGAGTTCCACCTGCTCACAGGTTGGCTGGCTCAGCCAAGGTGGTGCCCTGCTCTGAGCATTCAGGCCAAGCCCATCCT GCACCATGGCCAGGTACAGATGCTGTCGCAGCCAGAGCCGGAGCAGATATTACCGCCAGAGACAAAGAAGTCGCAGACGAAGGAGGCGGA GCTGCCAGACACGGAGGAGAGCCATGAAGCCAGAGCCTTTTAAGTCCATCATCTGGATACATGCCCATGAACCAGGGTAATCTTGGGGAG |
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FusionGenePPI for RANBP3_PRM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RANBP3 | XPO1, DEDD, BSG, KHK, RCC1, RAN, ELAVL1, RGPD1, AURKA, PHPT1, ALB, HSPA4L, NAP1L1, PPAT, DNAJB4, FAF1, FARSB, GART, HIRIP3, HSPH1, PLOD2, RPL24, RPL27A, SAMHD1, SET, SF1, SUPT5H, SWAP70, UGP2, XPO7, XRCC6, TROVE2, MEOX1, BLZF1, ZMIZ2, MORN4, KRTAP10-8, MOV10, NXF1, PPARG, SMARCD1, SMARCD3, NTRK1, CHN2, ANKS1A | PRM1 | SRPK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANBP3_PRM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANBP3_PRM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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