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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30332

FusionGeneSummary for RANBP1_NUMB

check button Fusion gene summary
Fusion gene informationFusion gene name: RANBP1_NUMB
Fusion gene ID: 30332
HgeneTgene
Gene symbol

RANBP1

NUMB

Gene ID

5902

8650

Gene nameRAN binding protein 1NUMB, endocytic adaptor protein
SynonymsHTF9AC14orf41|S171|c14_5527
Cytomap

22q11.21

14q24.2-q24.3

Type of geneprotein-codingprotein-coding
Descriptionran-specific GTPase-activating proteinHpaII tiny fragments locus 9Atestis secretory sperm-binding protein Li 221nprotein numb homologh-Numbnumb homolog
Modification date2018052320180522
UniProtAcc

P43487

P49757

Ensembl transtripts involved in fusion geneENST00000430524, ENST00000402752, 
ENST00000331821, ENST00000467920, 
ENST00000554546, ENST00000356296, 
ENST00000557597, ENST00000555238, 
ENST00000355058, ENST00000359560, 
ENST00000555394, ENST00000454166, 
ENST00000544991, ENST00000560335, 
ENST00000555738, ENST00000559312, 
ENST00000554521, ENST00000535282, 
ENST00000556600, ENST00000556772, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: RANBP1 [Title/Abstract] AND NUMB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD248988RANBP1chr22

20114706

+NUMBchr14

73824107

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000430524ENST00000554546RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000356296RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000557597RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000555238RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000355058RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000359560RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000555394RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000454166RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000544991RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000560335RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000555738RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000559312RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000554521RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000535282RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000556600RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000430524ENST00000556772RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000554546RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000356296RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000557597RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000555238RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000355058RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000359560RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000555394RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000454166RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000544991RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000560335RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000555738RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000559312RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000554521RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000535282RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000556600RANBP1chr22

20114706

+NUMBchr14

73824107

+
3UTR-intronENST00000402752ENST00000556772RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000554546RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000356296RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000557597RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000555238RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000355058RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000359560RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000555394RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000454166RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000544991RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000560335RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000555738RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000559312RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000554521RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000535282RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000556600RANBP1chr22

20114706

+NUMBchr14

73824107

+
5CDS-intronENST00000331821ENST00000556772RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000554546RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000356296RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000557597RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000555238RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000355058RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000359560RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000555394RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000454166RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000544991RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000560335RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000555738RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000559312RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000554521RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000535282RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000556600RANBP1chr22

20114706

+NUMBchr14

73824107

+
intron-intronENST00000467920ENST00000556772RANBP1chr22

20114706

+NUMBchr14

73824107

+

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FusionProtFeatures for RANBP1_NUMB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RANBP1

P43487

NUMB

P49757

Plays a role in RAN-dependent nucleocytoplasmictransport. Alleviates the TNPO1-dependent inhibition of RAN GTPaseactivity and mediates the dissociation of RAN from proteinsinvolved in transport into the nucleus (By similarity). Induces aconformation change in the complex formed by XPO1 and RAN thattriggers the release of the nuclear export signal of cargoproteins (PubMed:20485264). Promotes the disassembly of thecomplex formed by RAN and importin beta. Promotes dissociation ofRAN from a complex with KPNA2 and CSE1L (By similarity). Requiredfor normal mitotic spindle assembly and normal progress throughmitosis via its effect on RAN (PubMed:17671426). Does not increasethe RAN GTPase activity by itself, but increases GTP hydrolysismediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependentexchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957).{ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426,ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957,ECO:0000269|PubMed:7882974}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RANBP1_NUMB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RANBP1_NUMB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RANBP1_NUMB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RANBP1_NUMB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRANBP1C0019693HIV Infections1CTD_human
HgeneRANBP1C0036341Schizophrenia1PSYGENET