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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3033

FusionGeneSummary for ASRGL1_MYBL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ASRGL1_MYBL2
Fusion gene ID: 3033
HgeneTgene
Gene symbol

ASRGL1

MYBL2

Gene ID

80150

4605

Gene nameasparaginase like 1MYB proto-oncogene like 2
SynonymsALP|ALP1|CRASHB-MYB|BMYB
Cytomap

11q12.3

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionisoaspartyl peptidase/L-asparaginaseL-asparaginaseL-asparagine amidohydrolaseasparaginase-like 1 proteinasparaginase-like protein 1beta-aspartyl-peptidaseisoaspartyl dipeptidasetestis secretory sperm-binding protein Li 242mPmyb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2
Modification date2018052320180523
UniProtAcc

Q7L266

P10244

Ensembl transtripts involved in fusion geneENST00000415229, ENST00000535727, 
ENST00000301776, ENST00000528206, 
ENST00000396863, ENST00000217026, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 5 X 3=60
# samples 58
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASRGL1 [Title/Abstract] AND MYBL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASRGL1

GO:0033345

asparagine catabolic process via L-aspartate

19839645

TgeneMYBL2

GO:0045944

positive regulation of transcription by RNA polymerase II

10770937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI655904ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
ChiTaRS3.1BF056302ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000415229ENST00000396863ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
In-frameENST00000415229ENST00000217026ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
intron-3CDSENST00000535727ENST00000396863ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
intron-3CDSENST00000535727ENST00000217026ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
In-frameENST00000301776ENST00000396863ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
In-frameENST00000301776ENST00000217026ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
intron-3CDSENST00000528206ENST00000396863ASRGL1chr11

62123847

-MYBL2chr20

42341699

-
intron-3CDSENST00000528206ENST00000217026ASRGL1chr11

62123847

-MYBL2chr20

42341699

-

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FusionProtFeatures for ASRGL1_MYBL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASRGL1

Q7L266

MYBL2

P10244

Has both L-asparaginase and beta-aspartyl peptidaseactivity. May be involved in the production of L-aspartate, whichcan act as an excitatory neurotransmitter in some brain regions.Is highly active with L-Asp beta-methyl ester. Besides, hascatalytic activity toward beta-aspartyl dipeptides and theirmethyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methylester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and isinactive toward GlcNAc-L-Asn. Likewise, has no activity towardglutamine. {ECO:0000269|PubMed:19839645}. Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASRGL1_MYBL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0aa

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000415229_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000396863_chr20_42341699_-_0nt

>In-frame_ASRGL1_ENST00000301776_chr11_62123847_-_MYBL2_ENST00000217026_chr20_42341699_-_0nt


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FusionGenePPI for ASRGL1_MYBL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASRGL1_MYBL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASRGL1_MYBL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASRGL1C0162820Dermatitis, Allergic Contact1CTD_human