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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30319

FusionGeneSummary for RAMP3_RAMP3

check button Fusion gene summary
Fusion gene informationFusion gene name: RAMP3_RAMP3
Fusion gene ID: 30319
HgeneTgene
Gene symbol

RAMP3

RAMP3

Gene ID

10268

10268

Gene namereceptor activity modifying protein 3receptor activity modifying protein 3
Synonyms--
Cytomap

7p13

7p13

Type of geneprotein-codingprotein-coding
Descriptionreceptor activity-modifying protein 3CRLR activity-modifying protein 3calcitonin receptor-like receptor activity modifying protein 3receptor (G protein-coupled) activity modifying protein 3receptor (calcitonin) activity modifying protein 3receptor activity-modifying protein 3CRLR activity-modifying protein 3calcitonin receptor-like receptor activity modifying protein 3receptor (G protein-coupled) activity modifying protein 3receptor (calcitonin) activity modifying protein 3
Modification date2018052320180523
UniProtAcc

O60896

O60896

Ensembl transtripts involved in fusion geneENST00000242249, ENST00000496212, 
ENST00000481345, 
ENST00000242249, 
ENST00000496212, ENST00000481345, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RAMP3 [Title/Abstract] AND RAMP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAMP3

GO:0001921

positive regulation of receptor recycling

15613468

HgeneRAMP3

GO:0006816

calcium ion transport

10882736

HgeneRAMP3

GO:0015031

protein transport

9620797|10882736

HgeneRAMP3

GO:0031623

receptor internalization

10882736|15613468

HgeneRAMP3

GO:0072659

protein localization to plasma membrane

10882736

HgeneRAMP3

GO:1903078

positive regulation of protein localization to plasma membrane

23674134

TgeneRAMP3

GO:0001921

positive regulation of receptor recycling

15613468

TgeneRAMP3

GO:0006816

calcium ion transport

10882736

TgeneRAMP3

GO:0015031

protein transport

9620797|10882736

TgeneRAMP3

GO:0031623

receptor internalization

10882736|15613468

TgeneRAMP3

GO:0072659

protein localization to plasma membrane

10882736

TgeneRAMP3

GO:1903078

positive regulation of protein localization to plasma membrane

23674134


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE044279RAMP3chr7

45223278

-RAMP3chr7

45223615

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000242249ENST00000242249RAMP3chr7

45223278

-RAMP3chr7

45223615

-
3UTR-intronENST00000242249ENST00000496212RAMP3chr7

45223278

-RAMP3chr7

45223615

-
3UTR-intronENST00000242249ENST00000481345RAMP3chr7

45223278

-RAMP3chr7

45223615

-
intron-3UTRENST00000496212ENST00000242249RAMP3chr7

45223278

-RAMP3chr7

45223615

-
intron-intronENST00000496212ENST00000496212RAMP3chr7

45223278

-RAMP3chr7

45223615

-
intron-intronENST00000496212ENST00000481345RAMP3chr7

45223278

-RAMP3chr7

45223615

-
intron-3UTRENST00000481345ENST00000242249RAMP3chr7

45223278

-RAMP3chr7

45223615

-
intron-intronENST00000481345ENST00000496212RAMP3chr7

45223278

-RAMP3chr7

45223615

-
intron-intronENST00000481345ENST00000481345RAMP3chr7

45223278

-RAMP3chr7

45223615

-

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FusionProtFeatures for RAMP3_RAMP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAMP3

O60896

RAMP3

O60896

Plays a role in cardioprotection by reducing cardiachypertrophy and perivascular fibrosis in a GPER1-dependent manner.Transports the calcitonin gene-related peptide type 1 receptor(CALCRL) and GPER1 to the plasma membrane. Acts as a receptor foradrenomedullin (AM) together with CALCRL.{ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}. Plays a role in cardioprotection by reducing cardiachypertrophy and perivascular fibrosis in a GPER1-dependent manner.Transports the calcitonin gene-related peptide type 1 receptor(CALCRL) and GPER1 to the plasma membrane. Acts as a receptor foradrenomedullin (AM) together with CALCRL.{ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAMP3_RAMP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAMP3_RAMP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAMP3_RAMP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRAMP3O60896DB01278PramlintideReceptor activity-modifying protein 3biotechapproved|investigational
TgeneRAMP3O60896DB01278PramlintideReceptor activity-modifying protein 3biotechapproved|investigational

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RelatedDiseases for RAMP3_RAMP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource