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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30296

FusionGeneSummary for RALGPS2_SLC22A17

check button Fusion gene summary
Fusion gene informationFusion gene name: RALGPS2_SLC22A17
Fusion gene ID: 30296
HgeneTgene
Gene symbol

RALGPS2

SLC22A17

Gene ID

55103

51310

Gene nameRal GEF with PH domain and SH3 binding motif 2solute carrier family 22 member 17
SynonymsdJ595C2.124p3R|BOCT|BOIT|NGALR|NGALR2|NGALR3|hBOIT
Cytomap

1q25.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionras-specific guanine nucleotide-releasing factor RalGPS2Ral-A exchange factor RalGPS2ral GEF with PH domain and SH3-binding motif 2ralA exchange factor RalGPS2solute carrier family 22 member 1724p3 receptorNGAL receptorbrain-type organic cation transporterlipocalin-2 receptorneutrophil gelatinase-associated lipocalin receptorpotent brain type organic ion transportersolute carrier family 22 (organic catio
Modification date2018052220180522
UniProtAcc

Q86X27

Q8WUG5

Ensembl transtripts involved in fusion geneENST00000367635, ENST00000367634, 
ENST00000477383, 
ENST00000354772, 
ENST00000397260, ENST00000474057, 
ENST00000206544, ENST00000397267, 
Fusion gene scores* DoF score4 X 6 X 4=963 X 3 X 2=18
# samples 63
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RALGPS2 [Title/Abstract] AND SLC22A17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX112360RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000367635ENST00000354772RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367635ENST00000397260RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-5UTRENST00000367635ENST00000474057RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367635ENST00000206544RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367635ENST00000397267RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367634ENST00000354772RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367634ENST00000397260RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-5UTRENST00000367634ENST00000474057RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367634ENST00000206544RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
3UTR-3UTRENST00000367634ENST00000397267RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
intron-3UTRENST00000477383ENST00000354772RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
intron-3UTRENST00000477383ENST00000397260RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
intron-5UTRENST00000477383ENST00000474057RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
intron-3UTRENST00000477383ENST00000206544RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-
intron-3UTRENST00000477383ENST00000397267RALGPS2chr1

178885580

+SLC22A17chr14

23815616

-

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FusionProtFeatures for RALGPS2_SLC22A17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RALGPS2

Q86X27

SLC22A17

Q8WUG5

Guanine nucleotide exchange factor for the small GTPaseRALA. May be involved in cytoskeletal organization. May also beinvolved in the stimulation of transcription in a Ras-independentfashion (By similarity). {ECO:0000250}. Cell surface receptor for LCN2 (24p3) that plays a keyrole in iron homeostasis and transport. Able to bind iron-boundLCN2 (holo-24p3), followed by internalization of holo-24p3 andrelease of iron, thereby increasing intracellular ironconcentration and leading to inhibition of apoptosis. Also bindsiron-free LCN2 (apo-24p3), followed by internalization of apo-24p3and its association with an intracellular siderophore, leading toiron chelation and iron transfer to the extracellular medium,thereby reducing intracellular iron concentration and resulting inapoptosis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RALGPS2_SLC22A17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RALGPS2_SLC22A17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RALGPS2_SLC22A17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RALGPS2_SLC22A17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource