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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30282

FusionGeneSummary for RALGAPB_LBP

check button Fusion gene summary
Fusion gene informationFusion gene name: RALGAPB_LBP
Fusion gene ID: 30282
HgeneTgene
Gene symbol

RALGAPB

LBP

Gene ID

57148

3929

Gene nameRal GTPase activating protein non-catalytic beta subunitlipopolysaccharide binding protein
SynonymsKIAA1219|RalGAPbetaBPIFD2
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionral GTPase-activating protein subunit betaRal GTPase activating protein, beta subunit (non-catalytic)lipopolysaccharide-binding proteinBPI fold containing family D, member 2LPS-binding protein
Modification date2018052320180519
UniProtAcc

Q86X10

P18428

Ensembl transtripts involved in fusion geneENST00000262879, ENST00000397042, 
ENST00000397038, ENST00000537204, 
ENST00000397040, ENST00000490114, 
ENST00000217407, 
Fusion gene scores* DoF score11 X 10 X 8=8803 X 3 X 3=27
# samples 123
** MAII scorelog2(12/880*10)=-2.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RALGAPB [Title/Abstract] AND LBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLBP

GO:0015920

lipopolysaccharide transport

8985160

TgeneLBP

GO:0031663

lipopolysaccharide-mediated signaling pathway

8409400|11739189

TgeneLBP

GO:0032490

detection of molecule of bacterial origin

11528597

TgeneLBP

GO:0032496

response to lipopolysaccharide

8409400|11739189

TgeneLBP

GO:0032720

negative regulation of tumor necrosis factor production

11739189

TgeneLBP

GO:0032755

positive regulation of interleukin-6 production

8409400

TgeneLBP

GO:0032757

positive regulation of interleukin-8 production

8409400

TgeneLBP

GO:0032760

positive regulation of tumor necrosis factor production

8409400|12594207

TgeneLBP

GO:0033036

macromolecule localization

15294986

TgeneLBP

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

11528597

TgeneLBP

GO:0043032

positive regulation of macrophage activation

8409400

TgeneLBP

GO:0045919

positive regulation of cytolysis

15294986

TgeneLBP

GO:0050829

defense response to Gram-negative bacterium

11528597

TgeneLBP

GO:0050830

defense response to Gram-positive bacterium

12932360

TgeneLBP

GO:0071222

cellular response to lipopolysaccharide

12594207

TgeneLBP

GO:0071223

cellular response to lipoteichoic acid

12594207


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A4NA-01ARALGAPBchr20

37101712

+LBPchr20

36999924

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000262879ENST00000217407RALGAPBchr20

37101712

+LBPchr20

36999924

+
5UTR-3CDSENST00000397042ENST00000217407RALGAPBchr20

37101712

+LBPchr20

36999924

+
5UTR-3CDSENST00000397038ENST00000217407RALGAPBchr20

37101712

+LBPchr20

36999924

+
5UTR-3CDSENST00000537204ENST00000217407RALGAPBchr20

37101712

+LBPchr20

36999924

+
intron-3CDSENST00000397040ENST00000217407RALGAPBchr20

37101712

+LBPchr20

36999924

+
intron-3CDSENST00000490114ENST00000217407RALGAPBchr20

37101712

+LBPchr20

36999924

+

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FusionProtFeatures for RALGAPB_LBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RALGAPB

Q86X10

LBP

P18428

Plays a role in the innate immune response. Binds to thelipid A moiety of bacterial lipopolysaccharides (LPS), aglycolipid present in the outer membrane of all Gram-negativebacteria (PubMed:7517398, PubMed:24120359). Acts as an affinityenhancer for CD14, facilitating its association with LPS. Promotesthe release of cytokines in response to bacteriallipopolysaccharide (PubMed:7517398, PubMed:24120359).{ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493,ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398,ECO:0000305|PubMed:17481951}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RALGAPB_LBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RALGAPB_LBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RALGAPBSLMAP, DND1, GFOD1, NTRK1, PTPRH, NKIRAS2, DPH7, C12orf74, SERPINB2, LINC01587, BTRCLBPCFHR1, APOA1, CD14, CBFA2T2, C4BPA, FTH1, BAG6, BST1, HSPB1, SMAD3, PSMA3, SETD1A, PRDX4, TRA2A, PYCRL, TSC22D4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RALGAPB_LBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RALGAPB_LBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLBPC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneLBPC0001969Alcoholic Intoxication1PSYGENET
TgeneLBPC0026766Multiple Organ Failure1CTD_human
TgeneLBPC0028754Obesity1CTD_human
TgeneLBPC0043094Weight Gain1CTD_human
TgeneLBPC0243026Sepsis1CTD_human
TgeneLBPC0524620Metabolic Syndrome X1CTD_human
TgeneLBPC4277682Chemical and Drug Induced Liver Injury1CTD_human