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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30273

FusionGeneSummary for RALGAPA2_ZNFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: RALGAPA2_ZNFX1
Fusion gene ID: 30273
HgeneTgene
Gene symbol

RALGAPA2

ZNFX1

Gene ID

57186

57169

Gene nameRal GTPase activating protein catalytic alpha subunit 2zinc finger NFX1-type containing 1
SynonymsAS250|C20orf74|bA287B20.1|dJ1049G11|dJ1049G11.4|p220-
Cytomap

20p11.23

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionral GTPase-activating protein subunit alpha-2250 kDa substrate of AktRal GTPase activating protein, alpha subunit 2 (catalytic)RapGAPalpha2akt substrate AS250ral GTPase-activating protein alpha subunit 2NFX1-type zinc finger-containing protein 1
Modification date2018052320180523
UniProtAcc

Q2PPJ7

Q9P2E3

Ensembl transtripts involved in fusion geneENST00000202677, ENST00000495793, 
ENST00000371754, ENST00000469991, 
ENST00000371752, ENST00000396105, 
Fusion gene scores* DoF score7 X 5 X 6=21027 X 5 X 14=1890
# samples 831
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/1890*10)=-2.6080461138342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RALGAPA2 [Title/Abstract] AND ZNFX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5JJ-01ARALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000202677ENST00000371754RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
5CDS-5UTRENST00000202677ENST00000469991RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
5CDS-intronENST00000202677ENST00000371752RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
5CDS-intronENST00000202677ENST00000396105RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
intron-3CDSENST00000495793ENST00000371754RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
intron-5UTRENST00000495793ENST00000469991RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
intron-intronENST00000495793ENST00000371752RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-
intron-intronENST00000495793ENST00000396105RALGAPA2chr20

20693018

-ZNFX1chr20

47855837

-

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FusionProtFeatures for RALGAPA2_ZNFX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RALGAPA2

Q2PPJ7

ZNFX1

Q9P2E3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141741_1820-291919Coiled coilOntology_term=ECO:0000255
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-014286_313-291919Coiled coilOntology_term=ECO:0000255
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-014886_967-291919Coiled coilOntology_term=ECO:0000255
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141741_1820-831919Coiled coilOntology_term=ECO:0000255
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-014286_313-831919Coiled coilOntology_term=ECO:0000255
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-014886_967-831919Coiled coilOntology_term=ECO:0000255
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-014812_819-291919Compositional biasNote=Poly-Glu
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-014839_842-291919Compositional biasNote=Poly-Glu
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-014812_819-831919Compositional biasNote=Poly-Glu
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-014839_842-831919Compositional biasNote=Poly-Glu
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141298_1320-291919Zinc fingerNote=NF-X1-type 1
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141330_1346-291919Zinc fingerNote=NF-X1-type 2
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141382_1400-291919Zinc fingerNote=NF-X1-type 3
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141441_1463-291919Zinc fingerNote=NF-X1-type 4
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141471_1488-291919Zinc fingerNote=NF-X1-type 5
TgeneZNFX1chr20:20693018chr20:47855837ENST00000371752-0141546_1564-291919Zinc fingerNote=NF-X1-type 6
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141298_1320-831919Zinc fingerNote=NF-X1-type 1
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141330_1346-831919Zinc fingerNote=NF-X1-type 2
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141382_1400-831919Zinc fingerNote=NF-X1-type 3
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141441_1463-831919Zinc fingerNote=NF-X1-type 4
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141471_1488-831919Zinc fingerNote=NF-X1-type 5
TgeneZNFX1chr20:20693018chr20:47855837ENST00000396105-0141546_1564-831919Zinc fingerNote=NF-X1-type 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRALGAPA2chr20:20693018chr20:47855837ENST00000202677-140757_760351974Compositional biasNote=Poly-Gln
HgeneRALGAPA2chr20:20693018chr20:47855837ENST00000202677-140790_793351974Compositional biasNote=Poly-Ser
HgeneRALGAPA2chr20:20693018chr20:47855837ENST00000202677-1401635_1843351974DomainRap-GAP


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FusionGeneSequence for RALGAPA2_ZNFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RALGAPA2_ENST00000202677_chr20_20693018_-_ZNFX1_ENST00000371754_chr20_47855837_-_164aa
MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLAPLGLLDHCLLPLLQEPLCCIDLXRXQKDACRETRIYXHRKPRAANAWGSDGRNI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RALGAPA2_ENST00000202677_chr20_20693018_-_ZNFX1_ENST00000371754_chr20_47855837_-_493nt
ATGTTCTCCCGAAGGAGCCACGGGGATGTGAAGAAGTCCACCCAGAAGGTGCTGGACCCGAAGAAGGACGTGCTGACCCGCCTGAAGCAC
CTGCGGGCGCTGCTGGCTCCTCTCGGGCTCTTGGACCACTGCCTCCTTCCCCTTCTCCAGGAGCCGCTTTGCTGTATTGATCTGTAGAGA
TAACAAAAGGATGCCTGCCGTGAAACCCGTATCTACTAACACAGGAAGCCACGGGCTGCAAATGCCTGGGGCTCTGATGGGAGAAACATT
TCAGAAGGGCAGCACCAGCAGGGATGCAGCAGCTTGCTTACTGAGCAGCCTTGTGAACAAGATCCCGCCTCGCAGCCTCACCTGGGCTTC
TGACTGCTGCATCTCTTTTTCCTCCGCCTCTAGCTGCAGAACTGCATACACATCTTTCTCCATTTTCTCAATCTTGTCCCGGAATTTGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RALGAPA2_ENST00000202677_chr20_20693018_-_ZNFX1_ENST00000371754_chr20_47855837_-_1469nt
GCCGCGGGATGTTCTCCCGAAGGAGCCACGGGGATGTGAAGAAGTCCACCCAGAAGGTGCTGGACCCGAAGAAGGACGTGCTGACCCGCC
TGAAGCACCTGCGGGCGCTGCTGGCTCCTCTCGGGCTCTTGGACCACTGCCTCCTTCCCCTTCTCCAGGAGCCGCTTTGCTGTATTGATC
TGTAGAGATAACAAAAGGATGCCTGCCGTGAAACCCGTATCTACTAACACAGGAAGCCACGGGCTGCAAATGCCTGGGGCTCTGATGGGA
GAAACATTTCAGAAGGGCAGCACCAGCAGGGATGCAGCAGCTTGCTTACTGAGCAGCCTTGTGAACAAGATCCCGCCTCGCAGCCTCACC
TGGGCTTCTGACTGCTGCATCTCTTTTTCCTCCGCCTCTAGCTGCAGAACTGCATACACATCTTTCTCCATTTTCTCAATCTTGTCCCGG
AATTTGAGGATGACATCTCAATGGGAGAAAATAAAAAGGATTTACAAATAAGGGTAGGCCAGGCATGGTGGCTCACACCTGTAACCCGGC
ACTCTGGGAGATTGAGGTGGGAGGATTGCTTGAGCCCAGGAATTTGAGGCCAGCCTGGGCAACGTGGCCAGACTCTGTCTCTACAAAAAA
AAAAAAAAAAAAAAAAAAAGCCAGGCACAGTGGCTCATGCCTGTAATCCCACGCTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCA
GGAGTTTGAGACCAGCTTGGCCAATGCTGTGAAACCCCGTCTCTATTAAAAATACAAAAATCAGCTGGGTGTGGGGGCACACGCCTGTAA
TCCCAGCTACTACTCAGAAGGCTGAGGCAGGAGAACTGCTTGAACCCACGAGGCGGAGGCTGCAGTAAGCCAAGATGACACCACTACACT
CCAGCCTGGGCAAAAGAGCGAGACTCCATCTAAAAAAAAAAAAAAAATTAGCCATCATGGTGGCACACACCTGTAGTCCCACCTACTCAG
GAGGCTGAGGAGAAGAACTGCTTGAACCCAGGAGTTCGAGGCAACAGTAAGCTATGATCGCACCCCTGTACCCCAGCCTGGGCAACAAAG
CAAGACCTTATCTTAAACAAAATAAGGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAA
GAGATCGAGACCATCCTGGACAACATGGTGAAACCCCACCTGTACTAAAAATATAAAAATTAGCTGGGCGTGGTGGCATGCACCTGTAGT
CCCAGCTACTTGGGAGGCTGAGGCAGGAGGATCACTTGAACCCGGGACGCAGAGGTTGCAATGGGCCGAGATCGCACCACTGCACTCCAG
CCTGGCAACAGAGCAAGACTCCATCTCAAAAATAAATTAAATAAAATAAAATAAGGGTGACTACTAATACTGTGTAACTGATGAAAATAA


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FusionGenePPI for RALGAPA2_ZNFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RALGAPA2GFOD1, SPRTN, NKIRAS2, DPH7, MTMR7ZNFX1ENO1, SHMT2, MOV10, NXF1, XPO1, FYN, CSDE1, DROSHA, SS18L2, AMZ2, MIEF1, IMP3, DDX27, CDK4, HSF2, PCDH1, PDK1, SCAF11, UGGT1, CXXC4, TUBA1C, DRC1, LACTB, STRAP, OS9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RALGAPA2_ZNFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RALGAPA2_ZNFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource