	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 30237

FusionGeneSummary for RAI14_SORBS2

Fusion gene summary

Fusion gene information	Fusion gene name: RAI14_SORBS2
	Fusion gene ID: 30237
		Hgene	Tgene
	Gene symbol	RAI14	SORBS2
	Gene ID	26064	8470
	Gene name	retinoic acid induced 14	sorbin and SH3 domain containing 2
	Synonyms	NORPEG\|RAI13	ARGBP2\|PRO0618
	Cytomap	5p13.2	4q35.1
	Type of gene	protein-coding	protein-coding
	Description	ankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14	sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2
	Modification date	20180522	20180523
	UniProtAcc	Q9P0K7	O94875
	Ensembl transtripts involved in fusion gene	ENST00000265109, ENST00000512629, ENST00000428746, ENST00000503673, ENST00000515799, ENST00000506376, ENST00000507276, ENST00000397449,	ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125,
Fusion gene scores	* DoF score	11 X 8 X 4=352	11 X 12 X 7=924
	# samples	13	15
	** MAII score	log2(13/352*10)=-1.43706380560884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/924*10)=-2.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAI14 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF844204	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000265109	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000265109	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000512629	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000428746	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000503673	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000515799	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000506376	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000507276	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000448662	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000431808	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000284776	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000437304	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000319471	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000449407	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000355634	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000393528	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000418609	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+
intron-intron	ENST00000397449	ENST00000498125	RAI14	chr5	34661299	-	SORBS2	chr4	186720373	+

Top

FusionProtFeatures for RAI14_SORBS2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAI14 Q9P0K7	SORBS2 O94875
Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250\|UniProtKB:Q5U312}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for RAI14_SORBS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RAI14_SORBS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for RAI14_SORBS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for RAI14_SORBS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SORBS2	C0043094	Weight Gain	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 30237

FusionGeneSummary for RAI14_SORBS2

FusionProtFeatures for RAI14_SORBS2

FusionGeneSequence for RAI14_SORBS2

FusionGenePPI for RAI14_SORBS2

RelatedDrugs for RAI14_SORBS2

RelatedDiseases for RAI14_SORBS2