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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30237

FusionGeneSummary for RAI14_SORBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: RAI14_SORBS2
Fusion gene ID: 30237
HgeneTgene
Gene symbol

RAI14

SORBS2

Gene ID

26064

8470

Gene nameretinoic acid induced 14sorbin and SH3 domain containing 2
SynonymsNORPEG|RAI13ARGBP2|PRO0618
Cytomap

5p13.2

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2
Modification date2018052220180523
UniProtAcc

Q9P0K7

O94875

Ensembl transtripts involved in fusion geneENST00000265109, ENST00000512629, 
ENST00000428746, ENST00000503673, 
ENST00000515799, ENST00000506376, 
ENST00000507276, ENST00000397449, 
ENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
Fusion gene scores* DoF score11 X 8 X 4=35211 X 12 X 7=924
# samples 1315
** MAII scorelog2(13/352*10)=-1.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAI14 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF844204RAI14chr5

34661299

-SORBS2chr4

186720373

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000265109ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000265109ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000512629ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000428746ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000503673ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000515799ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000506376ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000507276ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000448662RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000431808RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000284776RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000437304RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000319471RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000449407RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000355634RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000393528RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000418609RAI14chr5

34661299

-SORBS2chr4

186720373

+
intron-intronENST00000397449ENST00000498125RAI14chr5

34661299

-SORBS2chr4

186720373

+

Top

FusionProtFeatures for RAI14_SORBS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAI14

Q9P0K7

SORBS2

O94875

Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250|UniProtKB:Q5U312}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAI14_SORBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAI14_SORBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RAI14_SORBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RAI14_SORBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSORBS2C0043094Weight Gain1CTD_human