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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30236

FusionGeneSummary for RAI14_SLC26A7

check button Fusion gene summary
Fusion gene informationFusion gene name: RAI14_SLC26A7
Fusion gene ID: 30236
HgeneTgene
Gene symbol

RAI14

SLC26A7

Gene ID

26064

115111

Gene nameretinoic acid induced 14solute carrier family 26 member 7
SynonymsNORPEG|RAI13SUT2
Cytomap

5p13.2

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14anion exchange transportersolute carrier family 26 (anion exchanger), member 7sulfate anion transporter
Modification date2018052220180523
UniProtAcc

Q9P0K7

Q8TE54

Ensembl transtripts involved in fusion geneENST00000265109, ENST00000512629, 
ENST00000428746, ENST00000503673, 
ENST00000515799, ENST00000506376, 
ENST00000507276, ENST00000397449, 
ENST00000523719, ENST00000276609, 
ENST00000309536, ENST00000520249, 
Fusion gene scores* DoF score11 X 8 X 4=3527 X 6 X 6=252
# samples 137
** MAII scorelog2(13/352*10)=-1.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAI14 [Title/Abstract] AND SLC26A7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC26A7

GO:0006820

anion transport

11834742

TgeneSLC26A7

GO:0006821

chloride transport

1183472

TgeneSLC26A7

GO:0008272

sulfate transport

1183472

TgeneSLC26A7

GO:0019532

oxalate transport

1183472


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF987124RAI14chr5

34824268

-SLC26A7chr8

92295186

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265109ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000265109ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000265109ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000265109ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000512629ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000512629ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000512629ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000512629ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000428746ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000428746ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000428746ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000428746ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000503673ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000503673ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000503673ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000503673ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000515799ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000515799ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000515799ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000515799ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000506376ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000506376ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000506376ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000506376ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
intron-intronENST00000507276ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
intron-intronENST00000507276ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
intron-intronENST00000507276ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
intron-intronENST00000507276ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000397449ENST00000523719RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000397449ENST00000276609RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000397449ENST00000309536RAI14chr5

34824268

-SLC26A7chr8

92295186

+
5CDS-intronENST00000397449ENST00000520249RAI14chr5

34824268

-SLC26A7chr8

92295186

+

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FusionProtFeatures for RAI14_SLC26A7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAI14

Q9P0K7

SLC26A7

Q8TE54

Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250|UniProtKB:Q5U312}. Acts as a sodium-independent DIDS-sensitive anionexchanger mediating bicarbonate, chloride, sulfate and oxalatetransport. May play a role in the maintenance of the electrolyteand acid-base homeostasis in the kidney, by acting as a distalexcretory segment-specific anion exchanger. Plays a major role ingastric acid secretion. {ECO:0000250|UniProtKB:Q8R2Z3,ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:12736153}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAI14_SLC26A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAI14_SLC26A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAI14_SLC26A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAI14_SLC26A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC26A7C0036341Schizophrenia1CTD_human