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Fusion gene ID: 30231 |
FusionGeneSummary for RAI14_CYB5R3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAI14_CYB5R3 | Fusion gene ID: 30231 | Hgene | Tgene | Gene symbol | RAI14 | CYB5R3 | Gene ID | 26064 | 1727 |
| Gene name | retinoic acid induced 14 | cytochrome b5 reductase 3 | |
| Synonyms | NORPEG|RAI13 | B5R|DIA1 | |
| Cytomap | 5p13.2 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14 | NADH-cytochrome b5 reductase 3NADH-cytochrome b5 reductase 3 membrane-bound formNADH-cytochrome b5 reductase 3 soluble formdiaphorase-1mutant NADH-cytochrome b5 reductase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9P0K7 | P00387 | |
| Ensembl transtripts involved in fusion gene | ENST00000265109, ENST00000512629, ENST00000428746, ENST00000503673, ENST00000515799, ENST00000506376, ENST00000507276, ENST00000397449, | ENST00000361740, ENST00000396303, ENST00000352397, ENST00000407623, ENST00000407332, ENST00000402438, | |
| Fusion gene scores | * DoF score | 11 X 8 X 4=352 | 3 X 3 X 2=18 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/352*10)=-1.43706380560884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/18*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAI14 [Title/Abstract] AND CYB5R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-FS-A4F4-06A | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000265109 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000265109 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000265109 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000265109 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000265109 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000265109 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000512629 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000512629 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000512629 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000512629 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000512629 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000512629 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000428746 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000428746 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000428746 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000428746 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000428746 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000428746 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000503673 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000503673 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000503673 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000503673 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| In-frame | ENST00000503673 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| Frame-shift | ENST00000503673 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| 5UTR-3CDS | ENST00000515799 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| 5UTR-3CDS | ENST00000515799 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| 5UTR-3CDS | ENST00000515799 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| 5UTR-3CDS | ENST00000515799 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| 5UTR-3CDS | ENST00000515799 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| 5UTR-3CDS | ENST00000515799 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000506376 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000506376 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000506376 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000506376 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000506376 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000506376 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000507276 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000507276 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000507276 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000507276 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000507276 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000507276 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000397449 | ENST00000361740 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000397449 | ENST00000396303 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000397449 | ENST00000352397 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000397449 | ENST00000407623 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000397449 | ENST00000407332 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
| intron-3CDS | ENST00000397449 | ENST00000402438 | RAI14 | chr5 | 34687060 | + | CYB5R3 | chr22 | 43015951 | - |
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FusionProtFeatures for RAI14_CYB5R3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAI14 | CYB5R3 |
| Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250|UniProtKB:Q5U312}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAI14_CYB5R3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAI14_ENST00000265109_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000265109_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000512629_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000512629_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000428746_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000428746_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000503673_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_69aa >In-frame_RAI14_ENST00000503673_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_69aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAI14_ENST00000265109_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000265109_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000512629_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000512629_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000428746_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000428746_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000503673_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC >In-frame_RAI14_ENST00000503673_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_209nt ATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTC CACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAI14_ENST00000265109_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_1461nt ATCCAGGTCGGCGGGGGCCGGCGCCCGGCGGCCACGTGGTGGTGCTGCCGCTGCCCCCGCCCCGCCGGCCTAGCCCGGGAGCTCGGCGCC CACTGACCCCCGCAGCGGGGGAGGAGGAGGGACTGCGGCGCAGGAAGCCGAGCAGGAAGCGAGCCCGGCGGCCGCGTTTTCCTGGGGAAG CGGCGGGCGGGGTGGAGCAGCCAGCTGGGTCCGGGGAGCGCCGCCGCCGCCTCGATGGGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAA GGCTGAATGCACTAAACATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGAT GATCCGGGACCACCTTCCACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAA CCTGGACCACGTGGGCCACCCCACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACG CCCTGTTCACGCTCACCCAGTCACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTG GCTGAGCAGTTCCCCTGGAGCCCCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCAC TTACTGGTCCTTACCAGAGACGCCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGC CAGCAGCCCCGTCTGCCCACCATTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCA GGGCCCACCCCAGCCTCGCCTGTCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACAC CAGAAAGCCCTCTTGGGGGCACTGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGG GCTGGCCATGGGGCCCTCCCAGAACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGT TGGCAGCCCACTGCACCGCCTCAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTA TTCCTCTGTCCTAAACCGTCCCCTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGA CCTCGACGTTGCCTTTAGACTACAGTTGTGTTAGCCTCTTGCGTATTGGCTTTTTCAGAGTCATTTATGAGCAGAAAAAAAAAAAGTAAA >In-frame_RAI14_ENST00000265109_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_1416nt ATCCAGGTCGGCGGGGGCCGGCGCCCGGCGGCCACGTGGTGGTGCTGCCGCTGCCCCCGCCCCGCCGGCCTAGCCCGGGAGCTCGGCGCC CACTGACCCCCGCAGCGGGGGAGGAGGAGGGACTGCGGCGCAGGAAGCCGAGCAGGAAGCGAGCCCGGCGGCCGCGTTTTCCTGGGGAAG CGGCGGGCGGGGTGGAGCAGCCAGCTGGGTCCGGGGAGCGCCGCCGCCGCCTCGATGGGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAA GGCTGAATGCACTAAACATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGAT GATCCGGGACCACCTTCCACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAA CCTGGACCACGTGGGCCACCCCACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACG CCCTGTTCACGCTCACCCAGTCACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTG GCTGAGCAGTTCCCCTGGAGCCCCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCAC TTACTGGTCCTTACCAGAGACGCCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGC CAGCAGCCCCGTCTGCCCACCATTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCA GGGCCCACCCCAGCCTCGCCTGTCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACAC CAGAAAGCCCTCTTGGGGGCACTGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGG GCTGGCCATGGGGCCCTCCCAGAACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGT TGGCAGCCCACTGCACCGCCTCAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTA TTCCTCTGTCCTAAACCGTCCCCTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGA >In-frame_RAI14_ENST00000512629_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_1259nt AGCTGGGTCCGGGGAGCGCCGCCGCCGCCTCGATGGGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAAGGCTGAATGCACTAAACATGAA GAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTCCACCC CCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCCACCCC ACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACGCCCTGTTCACGCTCACCCAGTC ACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTGGCTGAGCAGTTCCCCTGGAGCC CCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCACTTACTGGTCCTTACCAGAGACG CCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGCCAGCAGCCCCGTCTGCCCACCA TTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCAGGGCCCACCCCAGCCTCGCCTG TCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACACCAGAAAGCCCTCTTGGGGGCAC TGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGGGCTGGCCATGGGGCCCTCCCAG AACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGTTGGCAGCCCACTGCACCGCCTC AGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTATTCCTCTGTCCTAAACCGTCCC CTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGACCTCGACGTTGCCTTTAGACTA >In-frame_RAI14_ENST00000512629_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_1214nt AGCTGGGTCCGGGGAGCGCCGCCGCCGCCTCGATGGGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAAGGCTGAATGCACTAAACATGAA GAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTCCACCC CCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCCACCCC ACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACGCCCTGTTCACGCTCACCCAGTC ACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTGGCTGAGCAGTTCCCCTGGAGCC CCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCACTTACTGGTCCTTACCAGAGACG CCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGCCAGCAGCCCCGTCTGCCCACCA TTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCAGGGCCCACCCCAGCCTCGCCTG TCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACACCAGAAAGCCCTCTTGGGGGCAC TGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGGGCTGGCCATGGGGCCCTCCCAG AACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGTTGGCAGCCCACTGCACCGCCTC AGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTATTCCTCTGTCCTAAACCGTCCC CTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGACCTCGACGTTGCCTTTAGACTA >In-frame_RAI14_ENST00000428746_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_1449nt GATGGGGTGAGTGCGCGGCACGGAGTTGGGAGGCTCCCGGCGCGGGGTCCCGGGCTCGTGTCCCCGCCTTTGTGTCTGGAGCTCGGGCGC GGGAGGCGCTGGGGACGGCGCCCGGGCGGAGCGGCTGAGCGGGCTGCAGCCGGGGTCCCGCCACCTCTCCCTGGTCCACCGCCGGCAGCC CACTGTCTGCGGAGAGCAGATCTGGGGACAAGAGGAAGGAGAGGAAGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAAGGCTGAATGCAC TAAACATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCA CCTTCCACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGT GGGCCACCCCACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACGCCCTGTTCACGC TCACCCAGTCACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTGGCTGAGCAGTTC CCCTGGAGCCCCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCACTTACTGGTCCTT ACCAGAGACGCCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGCCAGCAGCCCCGT CTGCCCACCATTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCAGGGCCCACCCCA GCCTCGCCTGTCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACACCAGAAAGCCCTC TTGGGGGCACTGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGGGCTGGCCATGGG GCCCTCCCAGAACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGTTGGCAGCCCACT GCACCGCCTCAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTATTCCTCTGTCCT AAACCGTCCCCTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGACCTCGACGTTGC CTTTAGACTACAGTTGTGTTAGCCTCTTGCGTATTGGCTTTTTCAGAGTCATTTATGAGCAGAAAAAAAAAAAGTAAAACTTTGCTAATA >In-frame_RAI14_ENST00000428746_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_1404nt GATGGGGTGAGTGCGCGGCACGGAGTTGGGAGGCTCCCGGCGCGGGGTCCCGGGCTCGTGTCCCCGCCTTTGTGTCTGGAGCTCGGGCGC GGGAGGCGCTGGGGACGGCGCCCGGGCGGAGCGGCTGAGCGGGCTGCAGCCGGGGTCCCGCCACCTCTCCCTGGTCCACCGCCGGCAGCC CACTGTCTGCGGAGAGCAGATCTGGGGACAAGAGGAAGGAGAGGAAGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAAGGCTGAATGCAC TAAACATGAAGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCA CCTTCCACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGT GGGCCACCCCACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACGCCCTGTTCACGC TCACCCAGTCACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTGGCTGAGCAGTTC CCCTGGAGCCCCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCACTTACTGGTCCTT ACCAGAGACGCCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGCCAGCAGCCCCGT CTGCCCACCATTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCAGGGCCCACCCCA GCCTCGCCTGTCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACACCAGAAAGCCCTC TTGGGGGCACTGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGGGCTGGCCATGGG GCCCTCCCAGAACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGTTGGCAGCCCACT GCACCGCCTCAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTATTCCTCTGTCCT AAACCGTCCCCTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGACCTCGACGTTGC >In-frame_RAI14_ENST00000503673_chr5_34687060_+_CYB5R3_ENST00000352397_chr22_43015951_-_1530nt ACTCCCGCTGAGGCTGGGAAGATTGAAAGGGGCCATGGAGAGGCTGCAGTCACAATGAGGCCTCCAGATTCATGTCATCAAAGTGCTTCA TGATGACTGGATTTTCACACCATTTATCCAAGGGCCCTAGTCAATGGCAGCAGCAAGAATGAAAGTAGACACATTGGAAGCTAGAGAGTC ACTGGGTGACTTTTGGAGGTAGCAACAAGCTCATGAAGAAGGCATTCAGTGGCTTGCACTCCCCACCCATCCTCTCAACTACATGCGAAG TTTTCACATCTTGTACATTTCCAAATTTAATGAAAAAGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAAGGCTGAATGCACTAAACATGA AGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTCCACC CCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCCACCC CACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACGCCCTGTTCACGCTCACCCAGT CACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTGGCTGAGCAGTTCCCCTGGAGC CCCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCACTTACTGGTCCTTACCAGAGAC GCCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGCCAGCAGCCCCGTCTGCCCACC ATTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCAGGGCCCACCCCAGCCTCGCCT GTCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACACCAGAAAGCCCTCTTGGGGGCA CTGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGGGCTGGCCATGGGGCCCTCCCA GAACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGTTGGCAGCCCACTGCACCGCCT CAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTATTCCTCTGTCCTAAACCGTCC CCTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGACCTCGACGTTGCCTTTAGACT ACAGTTGTGTTAGCCTCTTGCGTATTGGCTTTTTCAGAGTCATTTATGAGCAGAAAAAAAAAAAGTAAAACTTTGCTAATATTAACCCTT >In-frame_RAI14_ENST00000503673_chr5_34687060_+_CYB5R3_ENST00000407332_chr22_43015951_-_1485nt ACTCCCGCTGAGGCTGGGAAGATTGAAAGGGGCCATGGAGAGGCTGCAGTCACAATGAGGCCTCCAGATTCATGTCATCAAAGTGCTTCA TGATGACTGGATTTTCACACCATTTATCCAAGGGCCCTAGTCAATGGCAGCAGCAAGAATGAAAGTAGACACATTGGAAGCTAGAGAGTC ACTGGGTGACTTTTGGAGGTAGCAACAAGCTCATGAAGAAGGCATTCAGTGGCTTGCACTCCCCACCCATCCTCTCAACTACATGCGAAG TTTTCACATCTTGTACATTTCCAAATTTAATGAAAAAGGTGTTGAAAAGTCTCCTCTAGAGCTTTGGAAGGCTGAATGCACTAAACATGA AGAGCTTGAAAGCGAAGTTCAGGAAGAGTGACCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTCCACC CCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCCACCC CACGGAGCGCTGCTTCGTCTTCTGAGGGCCGGGCACGGTCACACGGCCACCCGCCCCGCGCACCCCACGCCCTGTTCACGCTCACCCAGT CACCTCCCCACATCGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCTGGCTGAGCAGTTCCCCTGGAGC CCCTTCGGGAGCAGGGCTGTGTCCCAGATGGGCCACGGCTGAGCCTTCAGAGTACGTCCTGCCTGGCACTTACTGGTCCTTACCAGAGAC GCCCAGCCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCCCACACACACTATAAGGCTGAGGGCTGCCAGCAGCCCCGTCTGCCCACC ATTCCCGGCCGTGGACCATAGTCGGGATGTCAGCAGACACACATGGGCAGCCCAAAGCTGCAGGTGCCAGGGCCCACCCCAGCCTCGCCT GTCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACGCTGCATGAGACATTGACACCAGAAAGCCCTCTTGGGGGCA CTGCTCCCTACCCCAGGGCCCTGGCCAGCCGGGAGCTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGGGCTGGCCATGGGGCCCTCCCA GAACCTCAGCATTTCCTTCCAGCCCATCCAAACACTGAGGCAGCCTTGGGGAACCCCGAGCTGGGGGGTTGGCAGCCCACTGCACCGCCT CAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAACTCCCACAACCACATGTATTTATTCCTCTGTCCTAAACCGTCC CCTCCTTCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTTGTCTGAGGGACATATCAGTGACCTCGACGTTGCCTTTAGACT |
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FusionGenePPI for RAI14_CYB5R3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAI14 | YWHAB, YWHAG, YWHAQ, YWHAZ, FEZ1, FEZ2, DDX58, ITSN1, FBXO25, LRRK2, MDC1, PAN2, RPA1, RPA2, RPA3, PARP16, PSMC3, ZFP41, PLK1, TRIOBP, MED4, RPGRIP1L, TMEM17, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, PDLIM7, VPS26A, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZNF746, CDH1, VTN, VAPB, PACSIN1, VAPA, CAV3, BTRC, PACSIN2, NECAB1, PACSIN3, TRIM25, RNF168 | CYB5R3 | UBC, SPP1, CDK2, SDHA, HSPA1L, RPS7, SLC1A5, PARK2, ENO1, MOV10, NXF1, HOXB5, TSPAN5, RTN4, ACTL6A, RNF26, CPVL, CYP1A1, ATP5F1, CYB5B, PTEN, TCTN2, TCTN3, CEP290, CNTRL, SCLT1, STIL, TMEM17, COQ9, C15orf48, NDUFA4, OCIAD1, FAM136A, CHCHD10, NDUFS3, RTN1, SNRNP27, TSPAN11, USP47, SLC37A3, GML, MRPS11, HSPA8, AMTN, PDHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAI14_CYB5R3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAI14_CYB5R3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CYB5R3 | C0268193 | NADH cytochrome B5 reductase deficiency | 9 | CTD_human;UNIPROT |
| Tgene | CYB5R3 | C0010520 | Cyanosis | 1 | CTD_human;HPO |
| Tgene | CYB5R3 | C0025637 | Methemoglobinemia | 1 | CTD_human;HPO |
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