	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 3023

FusionGeneSummary for ASPH_TACC1

Fusion gene summary

Fusion gene information	Fusion gene name: ASPH_TACC1
	Fusion gene ID: 3023
		Hgene	Tgene
	Gene symbol	ASPH	TACC1
	Gene ID	444	6867
	Gene name	aspartate beta-hydroxylase	transforming acidic coiled-coil containing protein 1
	Synonyms	AAH\|BAH\|CASQ2BP1\|FDLAB\|HAAH\|JCTN\|junctin	Ga55
	Cytomap	8q12.3	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase	transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
	Modification date	20180519	20180523
	UniProtAcc	Q12797	O75410
	Ensembl transtripts involved in fusion gene	ENST00000541428, ENST00000379454, ENST00000523897, ENST00000522919, ENST00000356457, ENST00000518068, ENST00000517903, ENST00000445642, ENST00000517847, ENST00000522835, ENST00000517856, ENST00000389204, ENST00000522603, ENST00000379449, ENST00000517661,	ENST00000519416, ENST00000520615, ENST00000443286, ENST00000520340, ENST00000518415, ENST00000522752, ENST00000348567, ENST00000330691, ENST00000317827, ENST00000379931, ENST00000276520, ENST00000520973, ENST00000520611,
Fusion gene scores	* DoF score	11 X 9 X 6=594	14 X 13 X 8=1456
	# samples	12	15
	** MAII score	log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1456*10)=-3.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ASPH [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASPH	GO:0045862	positive regulation of proteolysis	18387192
Hgene	ASPH	GO:0097202	activation of cysteine-type endopeptidase activity	18387192

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-YC-A89H-01A	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000541428	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000541428	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000541428	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000541428	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000379454	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000379454	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000379454	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-5UTR	ENST00000523897	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-5UTR	ENST00000523897	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-5UTR	ENST00000523897	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000522919	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000522919	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000522919	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000356457	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000356457	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000356457	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000518068	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000518068	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000518068	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517903	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517903	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517903	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000445642	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000445642	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000445642	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517847	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517847	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517847	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522835	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522835	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522835	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517856	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517856	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517856	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000389204	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000389204	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000389204	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522603	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522603	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522603	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000379449	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000379449	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000379449	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517661	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517661	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517661	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+

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FusionProtFeatures for ASPH_TACC1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ASPH Q12797	TACC1 O75410

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ASPH_TACC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASPH_TACC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ASPH	SQSTM1, CUL3, APP, IQCB1, NOS2, TARDBP, ASNA1, PVRL3, HLA-E, FBLN7, PTCH1, OLFM1, ATL3, TCTN1, CCDC109B, MCU, STEAP3, FAM162A, TMEM160, STX4, SMDT1, NDUFAF1, WDYHV1, LEMD2, LYZL2, TMEM192, NELL2, ECSIT, CD93, STXBP3, BCHE, LRRC59, STX8, VTI1B, SERPINA12, EXD2, BNIP1, ACAD9, HTR2C, SLC7A6OS, TRIM25	TACC1	YEATS4, AURKB, AURKA, LSM7, TDRD7, CKAP5, SNRPG, BARD1, KAT2A, ITSN2, NIF3L1, S100A11, SLC9A3R1, C12orf57, PLXNB2, HTT, KDM1A, FBXW11, PRKRIR, STX5, BTRC, MEMO1, SH2D4A, DTNBP1, VAPB, LYST, VAPA, BRD3, RB1CC1, TACC2, BAIAP2L1, STAT2, RNF41, POC1B, KNSTRN, RPN2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ASPH_TACC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ASPH_TACC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ASPH	C1832167	Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism	1	ORPHANET;UNIPROT

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Fusion gene ID: 3023

FusionGeneSummary for ASPH_TACC1

FusionProtFeatures for ASPH_TACC1

FusionGeneSequence for ASPH_TACC1

FusionGenePPI for ASPH_TACC1

RelatedDrugs for ASPH_TACC1

RelatedDiseases for ASPH_TACC1