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Fusion gene ID: 30202 |
FusionGeneSummary for RAD9A_CLPB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD9A_CLPB | Fusion gene ID: 30202 | Hgene | Tgene | Gene symbol | RAD9A | CLPB | Gene ID | 5883 | 81570 |
| Gene name | RAD9 checkpoint clamp component A | ClpB homolog, mitochondrial AAA ATPase chaperonin | |
| Synonyms | RAD9 | ANKCLB|HSP78|MEGCANN|MGCA7|SKD3 | |
| Cytomap | 11q13.2 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell cycle checkpoint control protein RAD9ADNA repair exonuclease rad9 homolog ARAD9 homolog AhRAD9 | caseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q99638 | Q9H078 | |
| Ensembl transtripts involved in fusion gene | ENST00000307980, ENST00000535644, | ENST00000294053, ENST00000538039, ENST00000437826, ENST00000340729, ENST00000543042, ENST00000445069, ENST00000538021, ENST00000542555, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 8 X 7 X 7=392 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAD9A [Title/Abstract] AND CLPB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD9A | GO:0006974 | cellular response to DNA damage stimulus | 9872989 |
| Hgene | RAD9A | GO:0071479 | cellular response to ionizing radiation | 21659603 |
| Tgene | CLPB | GO:0034605 | cellular response to heat | 2745427 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A2GR-06A | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000307980 | ENST00000294053 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| In-frame | ENST00000307980 | ENST00000538039 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| Frame-shift | ENST00000307980 | ENST00000437826 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| In-frame | ENST00000307980 | ENST00000340729 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| 5CDS-intron | ENST00000307980 | ENST00000543042 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| 5CDS-intron | ENST00000307980 | ENST00000445069 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| 5CDS-intron | ENST00000307980 | ENST00000538021 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| 5CDS-5UTR | ENST00000307980 | ENST00000542555 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-3CDS | ENST00000535644 | ENST00000294053 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-3CDS | ENST00000535644 | ENST00000538039 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-3CDS | ENST00000535644 | ENST00000437826 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-3CDS | ENST00000535644 | ENST00000340729 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-intron | ENST00000535644 | ENST00000543042 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-intron | ENST00000535644 | ENST00000445069 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-intron | ENST00000535644 | ENST00000538021 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
| intron-5UTR | ENST00000535644 | ENST00000542555 | RAD9A | chr11 | 67159549 | + | CLPB | chr11 | 72141407 | - |
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FusionProtFeatures for RAD9A_CLPB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD9A | CLPB |
| Component of the 9-1-1 cell-cycle checkpoint responsecomplex that plays a major role in DNA repair. The 9-1-1 complexis recruited to DNA lesion upon damage by the RAD17-replicationfactor C (RFC) clamp loader complex. Acts then as a sliding clampplatform on DNA for several proteins involved in long-patch baseexcision repair (LP-BER). The 9-1-1 complex stimulates DNApolymerase beta (POLB) activity by increasing its affinity for the3'-OH end of the primer-template and stabilizes POLB to thosesites where LP-BER proceeds; endonuclease FEN1 cleavage activityon substrates with double, nick, or gap flaps of distinctsequences and lengths; and DNA ligase I (LIG1) on long-patch baseexcision repair substrates. The 9-1-1 complex is necessary for therecruitment of RHNO1 to sites of double-stranded breaks (DSB)occurring during the S phase. RAD9A possesses 3'->5' doublestranded DNA exonuclease activity. Its phosphorylation by PRKCDmay be required for the formation of the 9-1-1 complex.{ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:21659603}. | May function as a regulatory ATPase and be related tosecretion/protein trafficking process. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000294053 | - | 0 | 17 | 381_388 | 134 | 708 | Nucleotide binding | ATP |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000340729 | - | 0 | 15 | 381_388 | 134 | 649 | Nucleotide binding | ATP |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000437826 | - | 0 | 18 | 381_388 | 53 | 663 | Nucleotide binding | ATP |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000538039 | - | 0 | 16 | 381_388 | 134 | 678 | Nucleotide binding | ATP |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000294053 | - | 0 | 17 | 133_162 | 134 | 708 | Repeat | Note=ANK 1 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000294053 | - | 0 | 17 | 166_195 | 134 | 708 | Repeat | Note=ANK 2 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000294053 | - | 0 | 17 | 265_295 | 134 | 708 | Repeat | Note=ANK 3 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000294053 | - | 0 | 17 | 298_327 | 134 | 708 | Repeat | Note=ANK 4 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000340729 | - | 0 | 15 | 133_162 | 134 | 649 | Repeat | Note=ANK 1 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000340729 | - | 0 | 15 | 166_195 | 134 | 649 | Repeat | Note=ANK 2 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000340729 | - | 0 | 15 | 265_295 | 134 | 649 | Repeat | Note=ANK 3 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000340729 | - | 0 | 15 | 298_327 | 134 | 649 | Repeat | Note=ANK 4 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000437826 | - | 0 | 18 | 133_162 | 53 | 663 | Repeat | Note=ANK 1 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000437826 | - | 0 | 18 | 166_195 | 53 | 663 | Repeat | Note=ANK 2 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000437826 | - | 0 | 18 | 265_295 | 53 | 663 | Repeat | Note=ANK 3 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000437826 | - | 0 | 18 | 298_327 | 53 | 663 | Repeat | Note=ANK 4 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000538039 | - | 0 | 16 | 133_162 | 134 | 678 | Repeat | Note=ANK 1 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000538039 | - | 0 | 16 | 166_195 | 134 | 678 | Repeat | Note=ANK 2 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000538039 | - | 0 | 16 | 265_295 | 134 | 678 | Repeat | Note=ANK 3 |
| Tgene | >CLPB | chr11:67159549 | chr11:72141407 | ENST00000538039 | - | 0 | 16 | 298_327 | 134 | 678 | Repeat | Note=ANK 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RAD9A | chr11:67159549 | chr11:72141407 | ENST00000307980 | + | 1 | 11 | 51_91 | 11 | 392 | Region | Note=Possesses 3'-5' exonuclease activity |
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FusionGeneSequence for RAD9A_CLPB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000294053_chr11_72141407_-_585aa MKCLVTGGNVKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHS LEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPL DYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQ TAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKT IDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCH SELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKS >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000538039_chr11_72141407_-_555aa MKCLVTGGNVKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHS LEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAEE RRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKF IGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEA LEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDR EVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLD >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000340729_chr11_72141407_-_526aa MKCLVTGGNVKDAALLEAARANNMQEVSSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHY AVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIR RKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVL FDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKE NVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000294053_chr11_72141407_-_1755nt ATGAAGTGCCTGGTCACGGGCGGCAACGTGAAGGATGCAGCCCTGTTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGGCTG TTGTCAGAAGGTGCAGATGTCAATGCAAAGCACAGACTTGGCTGGACAGCACTCATGGTGGCAGCCATCAACCGAAACAACAGTGTGGTA CAGGTCCTGCTTGCTGCTGGGGCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATCCATTCT TTGGAAGATGGGGGACAGGACGGTGCAAGCCGGCACATCACAAACCAGTGGACAAGTGCCCTGGAGTTCAGGAGATGGCTAGGACTCCCC GCTGGCGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCT GTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTG GATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAG CGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGG AAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAG ACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTT ATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTT GATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACC ATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCT TTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAAT GTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCAC TCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGC GAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAG CTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGC CCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGAC >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000538039_chr11_72141407_-_1665nt ATGAAGTGCCTGGTCACGGGCGGCAACGTGAAGGATGCAGCCCTGTTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGGCTG TTGTCAGAAGGTGCAGATGTCAATGCAAAGCACAGACTTGGCTGGACAGCACTCATGGTGGCAGCCATCAACCGAAACAACAGTGTGGTA CAGGTCCTGCTTGCTGCTGGGGCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATCCATTCT TTGGAAGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCT GTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTG GATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAG CGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGG AAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAG ACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTT ATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTT GATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACC ATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCT TTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAAT GTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCAC TCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGC GAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAG CTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGC CCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGAC >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000340729_chr11_72141407_-_1578nt ATGAAGTGCCTGGTCACGGGCGGCAACGTGAAGGATGCAGCCCTGTTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGTGTG GTACAGGTCCTGCTTGCTGCTGGGGCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATCCAT TCTTTGGAAGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTAT GCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCC TTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAG GAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGG AGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAG CAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAG TTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTC TTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAG ACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAA GCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAG AATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGC CACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGAC CGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAAC CAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAA AGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000294053_chr11_72141407_-_2790nt GGGCCGGCAGGGGCGGTGCGCGGGAAGGGACCCCGGACCCGGAGGTCGCGGAGAGCTGGGCAGTGTTGGCCGCTGGCGGAGCGCTGGGGC AGCATGAAGTGCCTGGTCACGGGCGGCAACGTGAAGGATGCAGCCCTGTTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGG CTGTTGTCAGAAGGTGCAGATGTCAATGCAAAGCACAGACTTGGCTGGACAGCACTCATGGTGGCAGCCATCAACCGAAACAACAGTGTG GTACAGGTCCTGCTTGCTGCTGGGGCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATCCAT TCTTTGGAAGATGGGGGACAGGACGGTGCAAGCCGGCACATCACAAACCAGTGGACAAGTGCCCTGGAGTTCAGGAGATGGCTAGGACTC CCCGCTGGCGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTAT GCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCC TTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAG GAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGG AGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAG CAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAG TTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTC TTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAG ACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAA GCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAG AATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGC CACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGAC CGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAAC CAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAA AGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTG GACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATCCAATAAA GGCCCCTTGGCTGTGGCATGGCAACTGACTTACCTTCCCCTCATGCCGCTCCCATCTCTACCCAGTCTCAGGCCTGCTTACCTCCTCACA GCCCATGAAGACCCCTTCTCAGCCCCAAAACCTGAAGGAGGAATTTCGCCCTACTCTGGCCCCTTTGTTGTGGGCCCATAACCTGCTAAC AAGCCTTCAGGAGAGGAGCTGCCTTTCCACCCCCTTCAAGGCAAGGAGGGATGGAGGTCCCTTATTTCCTTCAGAATGATCCCCATCCCC CATAGTCGCCAGACTTTCTCATGTTCCCAGGAAGCTCAGAAGTATGGCAGCTAAGAACACAGCTGGCTGGAAGAAGACAGGGACCAGACT GAACTGCCACCCTCTGCTAGTCCTCATGCAACTCAGTCCCCAGAATGGCTCCACTGGGAGTGGAGGAAGAGCTCAGAGGCCCAGGTGCAG ATAGTTCTGCAATTTAGTCTGTAGCCTCCTCGTTCCCTACCCTAAAATTCTAAGGGGAAGGGACCCATAGAGGCTTGCCTGTTTCCGCTA CTATATTATGCCCAGTGTTCCTCCTCACCCCACGTCCTGGGGTCAGGCCAGACCATGTTTCGTCAGCCTTGGGGACTAGGCCAGTGTTGG GCACCTCCAGGAGGAGGCCTGACTGGTTCATTACCCTCCCCTACTCAGACTGAGCAGCAGTCCCAGATAACCAAGCAAGCTCAGCTCTGT GGGGGCCTCCTTCAAAAGACCAACATCGCAGACATTAGGAAGCTGTAGGAAGAGAGATCATGGGTTTGACCTCTGCCCACATGGCCATGG AGTCAGCCTCAGCCCTGTCTGTACTGCTCGTCCAGCTAAACGAGCCTGGAATAAACATGCAGTTTATTCAGTCTGCATGTTAGTCACAAA >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000538039_chr11_72141407_-_2679nt GGGCCGGCAGGGGCGGTGCGCGGGAAGGGACCCCGGACCCGGAGGTCGCGGAGAGCTGGGCAGTGTTGGCCGCTGGCGGAGCGCTGGGGC AGCATGAAGTGCCTGGTCACGGGCGGCAACGTGAAGGATGCAGCCCTGTTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGG CTGTTGTCAGAAGGTGCAGATGTCAATGCAAAGCACAGACTTGGCTGGACAGCACTCATGGTGGCAGCCATCAACCGAAACAACAGTGTG GTACAGGTCCTGCTTGCTGCTGGGGCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATCCAT TCTTTGGAAGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTAT GCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCC TTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAG GAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGG AGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAG CAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAG TTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTC TTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAG ACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAA GCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAG AATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGC CACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGAC CGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAAC CAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAA AGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTG GACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATCCAATAAA GGCCCCTTGGCTGTGGCATGGCAACTGACTTACCTTCCCCTCATGCCGCTCCCATCTCTACCCAGTCTCAGGCCTGCTTACCTCCTCACA GCCCATGAAGACCCCTTCTCAGCCCCAAAACCTGAAGGAGGAATTTCGCCCTACTCTGGCCCCTTTGTTGTGGGCCCATAACCTGCTAAC AAGCCTTCAGGAGAGGAGCTGCCTTTCCACCCCCTTCAAGGCAAGGAGGGATGGAGGTCCCTTATTTCCTTCAGAATGATCCCCATCCCC CATAGTCGCCAGACTTTCTCATGTTCCCAGGAAGCTCAGAAGTATGGCAGCTAAGAACACAGCTGGCTGGAAGAAGACAGGGACCAGACT GAACTGCCACCCTCTGCTAGTCCTCATGCAACTCAGTCCCCAGAATGGCTCCACTGGGAGTGGAGGAAGAGCTCAGAGGCCCAGGTGCAG ATAGTTCTGCAATTTAGTCTGTAGCCTCCTCGTTCCCTACCCTAAAATTCTAAGGGGAAGGGACCCATAGAGGCTTGCCTGTTTCCGCTA CTATATTATGCCCAGTGTTCCTCCTCACCCCACGTCCTGGGGTCAGGCCAGACCATGTTTCGTCAGCCTTGGGGACTAGGCCAGTGTTGG GCACCTCCAGGAGGAGGCCTGACTGGTTCATTACCCTCCCCTACTCAGACTGAGCAGCAGTCCCAGATAACCAAGCAAGCTCAGCTCTGT GGGGGCCTCCTTCAAAAGACCAACATCGCAGACATTAGGAAGCTGTAGGAAGAGAGATCATGGGTTTGACCTCTGCCCACATGGCCATGG >In-frame_RAD9A_ENST00000307980_chr11_67159549_+_CLPB_ENST00000340729_chr11_72141407_-_1735nt GGGCCGGCAGGGGCGGTGCGCGGGAAGGGACCCCGGACCCGGAGGTCGCGGAGAGCTGGGCAGTGTTGGCCGCTGGCGGAGCGCTGGGGC AGCATGAAGTGCCTGGTCACGGGCGGCAACGTGAAGGATGCAGCCCTGTTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGT GTGGTACAGGTCCTGCTTGCTGCTGGGGCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATC CATTCTTTGGAAGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCAC TATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACA CCCTTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCT GAGGAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATC CGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCC AAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCC AAGTTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTG CTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGG AAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAG GAAGCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAG GAGAATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTC TGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGG GACCGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTG AACCAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTC AAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGA CTGGACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATCCAAT |
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FusionGenePPI for RAD9A_CLPB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAD9A | BCL2L1, AR, NR3C1, RAD1, HUS1, RAD17, HUS1B, CLSPN, HDAC1, ABL1, DNAJC7, BCL2, TOPBP1, RPA1, RPA2, FEN1, ATR, SETMAR, DNMT1, SF3B3, PCNA, COPS5, FEM1B, MSH2, MSH6, MSH3, ATRX, RHNO1, C10orf2, TRIM25 | CLPB | TTF2, COPS6, UCHL3, USP30, OSBPL10, TERF2, CUL3, SMAD9, MDFI, HDAC11, IRS4, CEP70, ERCC6L, TSEN2, MGEA5, NTRK1, XPO1, MCM2, NDUFA4, PTPMT1, DHRS4, COQ9, C15orf48, CISD3, C2orf47, FAM136A, OPA3, TRUB2, COQ10B, OCIAD1, ADCK3, WBSCR16, ADCK4, NDUFS3, PAK7, ADCK2, CHCHD10, C17orf89, CDKN3, CLUH, KIAA1191, PAG1, ARFIP1, SETDB1, TRIM11, MTIF2, MDM2, GTPBP10, EXOG, EIF5, NAP1L5, FBXL13 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAD9A_CLPB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAD9A_CLPB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RAD9A | C0085183 | Neoplasms, Second Primary | 1 | CTD_human |
| Tgene | CLPB | C4225393 | 3-METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT, AND NEUTROPENIA | 2 | ORPHANET;UNIPROT |
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