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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30166

FusionGeneSummary for RAD50_C5orf56

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD50_C5orf56
Fusion gene ID: 30166
HgeneTgene
Gene symbol

RAD50

C5orf56

Gene ID

10111

441108

Gene nameRAD50 double strand break repair proteinchromosome 5 open reading frame 56
SynonymsNBSLD|RAD502|hRad50-
Cytomap

5q31.1

5q31.1

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD50RAD50 homolog, double strand break repair proteinuncharacterized protein C5orf56
Modification date2018052320180425
UniProtAcc

Q92878

Q8N8D9

Ensembl transtripts involved in fusion geneENST00000378823, ENST00000265335, 
ENST00000487596, 
ENST00000378953, 
ENST00000337752, ENST00000378947, 
ENST00000407797, ENST00000464024, 
Fusion gene scores* DoF score5 X 4 X 5=1004 X 3 X 4=48
# samples 54
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD50 [Title/Abstract] AND C5orf56 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD50

GO:0000019

regulation of mitotic recombination

8756642

HgeneRAD50

GO:0006281

DNA repair

9705271

HgeneRAD50

GO:0006310

DNA recombination

9705271

HgeneRAD50

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneRAD50

GO:0007004

telomere maintenance via telomerase

9705271

HgeneRAD50

GO:0031954

positive regulation of protein autophosphorylation

15790808

HgeneRAD50

GO:0033674

positive regulation of kinase activity

15790808

HgeneRAD50

GO:1904354

negative regulation of telomere capping

17694070


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A10T-01ARAD50chr5

131895059

+C5orf56chr5

131785342

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000378823ENST00000378953RAD50chr5

131895059

+C5orf56chr5

131785342

+
5UTR-3CDSENST00000378823ENST00000337752RAD50chr5

131895059

+C5orf56chr5

131785342

+
5UTR-3CDSENST00000378823ENST00000378947RAD50chr5

131895059

+C5orf56chr5

131785342

+
5UTR-3CDSENST00000378823ENST00000407797RAD50chr5

131895059

+C5orf56chr5

131785342

+
5UTR-intronENST00000378823ENST00000464024RAD50chr5

131895059

+C5orf56chr5

131785342

+
In-frameENST00000265335ENST00000378953RAD50chr5

131895059

+C5orf56chr5

131785342

+
In-frameENST00000265335ENST00000337752RAD50chr5

131895059

+C5orf56chr5

131785342

+
In-frameENST00000265335ENST00000378947RAD50chr5

131895059

+C5orf56chr5

131785342

+
In-frameENST00000265335ENST00000407797RAD50chr5

131895059

+C5orf56chr5

131785342

+
5CDS-intronENST00000265335ENST00000464024RAD50chr5

131895059

+C5orf56chr5

131785342

+
intron-3CDSENST00000487596ENST00000378953RAD50chr5

131895059

+C5orf56chr5

131785342

+
intron-3CDSENST00000487596ENST00000337752RAD50chr5

131895059

+C5orf56chr5

131785342

+
intron-3CDSENST00000487596ENST00000378947RAD50chr5

131895059

+C5orf56chr5

131785342

+
intron-3CDSENST00000487596ENST00000407797RAD50chr5

131895059

+C5orf56chr5

131785342

+
intron-intronENST00000487596ENST00000464024RAD50chr5

131895059

+C5orf56chr5

131785342

+

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FusionProtFeatures for RAD50_C5orf56


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAD50

Q92878

C5orf56

Q8N8D9

Component of the MRN complex, which plays a central rolein double-strand break (DSB) repair, DNA recombination,maintenance of telomere integrity and meiosis. The complexpossesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11.RAD50 may be required to bind DNA ends and hold them in closeproximity. This could facilitate searches for short or longregions of sequence homology in the recombining DNA templates, andmay also stimulate the activity of DNA ligases and/or restrict thenuclease activity of MRE11 to prevent nucleolytic degradation pasta given point (PubMed:11741547, PubMed:9590181, PubMed:9705271,PubMed:9651580). The complex may also be required for DNA damagesignaling via activation of the ATM kinase (PubMed:15064416). Intelomeres the MRN complex may modulate t-loop formation(PubMed:10888888). {ECO:0000269|PubMed:10888888,ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416,ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580,ECO:0000269|PubMed:9705271}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAD50_C5orf56


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000378953_chr5_131785342_+_173aa
MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRKTHQDHLCSL

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000337752_chr5_131785342_+_182aa
MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRKTHQGNLQTL
LLHWLLLCSCLHHLYNASCHPAFPVEYSHAVCCLQPRFWKEMSPFSSSSTTHLFSKCFFYTCLCWAWQQCSSEQNHQPCSHAAYNQVERQ

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000378947_chr5_131785342_+_136aa
MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRKTHQAYATLC

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000407797_chr5_131785342_+_93aa
MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRKTHQAPNSTV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000378953_chr5_131785342_+_519nt
ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC
CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA
ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAAACACACCAAGATCACCTCTGCAGCCTG
CACAGCCGGGCCTTTGGACTCCTGGATGCTAGAGTGACCTGGGCGCTGAGGAGGGCCCCCGAGCCAGTACCAGGAAAGGATAGACTCCTG
CTTGCAGCATTCCCAGCAGAGGCATCGCCTGTGGACACCGCGTCTGTGTCTGTATATGGCAGAGCTCCCAGATATATGCACAAGGGAGTG

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000337752_chr5_131785342_+_546nt
ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC
CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA
ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAAACACACCAAGGGAATCTTCAAACTCTT
CTTCTCCACTGGCTCCTGCTGTGCTCCTGTCTCCATCACCTGTATAATGCTTCCTGCCATCCTGCCTTCCCCGTGGAGTACAGCCATGCT
GTCTGCTGCTTACAGCCAAGATTCTGGAAAGAAATGTCTCCTTTTTCCTCGTCATCAACCACTCATTTATTCAGCAAGTGTTTCTTTTAC
ACTTGCCTGTGCTGGGCATGGCAGCAATGCAGCAGTGAACAAAACCATCAGCCCTGCTCTCATGCAGCTTATAATCAAGTAGAGAGACAG

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000378947_chr5_131785342_+_408nt
ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC
CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA
ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAAACACACCAAGCCTACGCCACTCTGTGC
CCTTTAGCCAAGGAAGCCCAGCTGAGGCCCCGCAGCGTCCCTGCCCAGCAGAGCTACAGGAGGCCCGAGGCCCCTTCCTGTTCACTCTTG

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000407797_chr5_131785342_+_279nt
ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC
CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA
ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAAACACACCAAGCCCCGAACAGCACAGTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000378953_chr5_131785342_+_1018nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGATCACCTCTGCAGCCTGCACAGCCGGGCCTTTGGACTCCTGGATGCTAGAGTGACCTGGGCGCTGAGGAGGGCCCCCGAG
CCAGTACCAGGAAAGGATAGACTCCTGCTTGCAGCATTCCCAGCAGAGGCATCGCCTGTGGACACCGCGTCTGTGTCTGTATATGGCAGA
GCTCCCAGATATATGCACAAGGGAGTGAAAAAATGTGTTTGCACCCCAGTCTCTAAAAATTCAACAGCCTGGTTACTTCTGGGTGGTATA
TCGTAGGTGGCTTTAATACGTGTTATTTGCTCATCTGTATTTCTTACTCTTTGCACAATTAAACCATGTTCCTTTTACTTATGTACATTT

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000337752_chr5_131785342_+_2446nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGGGAATCTTCAAACTCTTCTTCTCCACTGGCTCCTGCTGTGCTCCTGTCTCCATCACCTGTATAATGCTTCCTGCCATCCT
GCCTTCCCCGTGGAGTACAGCCATGCTGTCTGCTGCTTACAGCCAAGATTCTGGAAAGAAATGTCTCCTTTTTCCTCGTCATCAACCACT
CATTTATTCAGCAAGTGTTTCTTTTACACTTGCCTGTGCTGGGCATGGCAGCAATGCAGCAGTGAACAAAACCATCAGCCCTGCTCTCAT
GCAGCTTATAATCAAGTAGAGAGACAGACATAAATGATTAATAGATGCTCCTGTAATGGTGGTTGTGAGGTGTGCTGCCACAGCCCAGCC
ACACACGCCAGTTCCCTTCTCTGCACATGTACATGTCTGCTCATCCTTCCCACCTGAACTCATGTGCCACCTCACTTATGCCCCTTCCCA
ATGCCGCACCCACACAACAGGGTGTCCCTCTGTGCCCACAGCAGCCCTTGGGTATAACTGTTCCCCACAGAGGCTGAACCCCAAGGGCAG
AGTCCAGGCCACACTCACCACGGAGACCCCTGCCTGGCACAGAGCCCAGCCCAGCAGAGATGCTCAGAAGATGAATGAAAGTCCCTGCTG
AGATTGATCCAATCTGTTTGTGAACATCTCTGGGGTCCAAGAATTCACGGCTTTCTTTTTCTTTAGAGAGCCTTTTGTTTCTTTTTGCCA
TTATATACTATATTTGGGTTAGGGCACAACAATGTGAATATACTTAATACTGAACTCTACACTTGAAAATGGTTAAGATGGTAAAGTTTT
AAGTTATATGTATTTTGCCACAATTTTTTAAAATGCAGAGCATAGGTACAAAGAAGGAAAAAAAGGGGGCAAGGTCCATTTTATTGAGAA
ATAAAGAACAAAGGGTTCAATTCAGAGAGGATTGGATTTTAAAACGTAATTTAGATTAGGGAAATGCAAATGAAAACCATAATAAGTAAG
ATACCACTTCACATCTGTTAGGATGGCTATTTTAAAACAACAAAAACAACCTGAAAATAAGTGTTGGCAAGGATGTGAAGAAATAGATAC
CCTTGTGCATTGCTATTGGGAACGTAAAATCATGCAGCCTTTGTTGAAAACAATGTGGTGGTTCCTCAAAAACTTAGTTATCATATGATC
CCGCAGTTCCACTTCTAGGAATATACCCAAAAGAATTGAAAGCAGGGACTCAAAGTGATATTTGTACACCAGTGTTTGTAGCAGTATTAT
TCACAATAGCCAAAAGGTGGAAACAACCCAGATGTCCATGACAAGAGGAGTGGATAAACAAAATATGGTGAATATGTACAATGGAACATA
ATTCAGCTTTAAAAAGGAATGAAATTCTGGTACATGTTATAACATAGATGAACCTTAAAAACATTATGCTAAGTGAAATAAGCCAGACAC
AGAAGGAAAAATACCAGATGATCCCACTTATATGAGGTACCTAGAATAGTGAAATTCATAGAGACAGAAAGTAGAAGGATGGTTGCCAGG
GGCTGGAAGGAGGAAGAACAGGGAGATACTGCTTAGTGGATGCAGAGTTTATGTTGAGGGTGATGAAAAAGTTCTGGAGATGGATGGTGG
TGATGGCTGCACAACAGTGAGAATGTACTTCATACTATGGAACTCTGCACTTAAAAATGGTTAAAATGGATGTAGACATTTTATGTCTAT
TTTGCCATAACAAGAAAGTAATTTGGGTGTATTTTAGAGATTTTAGAAAATACTGTAAGCACAAGAGGAAAAAAATTAAAATCATTCGCA

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000378947_chr5_131785342_+_1050nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGCCTACGCCACTCTGTGCCCTTTAGCCAAGGAAGCCCAGCTGAGGCCCCGCAGCGTCCCTGCCCAGCAGAGCTACAGGAGG
CCCGAGGCCCCTTCCTGTTCACTCTTGCTCTATAGACGCCACGCTGCAAAGCAGATGTGCAGGGACACCACCTGAAGACCCAGCCTGCAG
CTCAGCCCTACACACTGTGGATGGTGGAGATCCCAGAGGGCCAAGAGAAGCTTATTGAGACTTCTCTGCACTGCCCCTCCCACAGCAGGA
GGTTCATGGCCCATGCATTTCTGGGAGGGTTGACAGGGCCCAGGTTGTGGAATACCTGTCTGTGAGCCCCATGTCCTGTCTTGTCCCAGC

>In-frame_RAD50_ENST00000265335_chr5_131895059_+_C5orf56_ENST00000407797_chr5_131785342_+_1509nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGCCCCGAACAGCACAGTGAATGGATAGGGCAGCAGATGAGCTCTGCCCCACGCCGGCCCTGTTTCAGAACAGCACTCCAGA
GTGCCGCACTGCTTGCTGAACCACAGCTGTTACTGCAGATTGAGGAGCCTCAGAGGGAACAGAAGATAAAGATCATTATGGAATTTAGGA
TTGCAGGACATTCTTTGACATTTCATAACAGCCAGGGGAGATCAACTGTGGTCAGGGGACAGGGGCAGGAAGAAACCATGGCCAAGGCCT
GTCTGGCAGGACTTGAAGGGGCAGAGGGACCCTTGCAAATGACCCTGCCTGGAACCCACCCCCAGTTGGCCCCTGTATAGCACTGATCCA
GCTGGGGCTTTTATCCCAGGATACCCTCTTCAGGGATGCCTGTATTTGTTGATTATCTGCCATATGCCTGGTCACTGCAGAATACAAGGA
AGAAAATAGCCTTCAGCAGAAGCTGAGACAGGAGCCTAGAGGATGGACAGTAAGGAGTCGAAGGCTCAGGATGAGGCTTTCCTGACTTTC
TCCCCTAGAGGACTGATGTTCTCTACTGGTACAGACCTTGTTTTATTCATCCTTATGTCCCTAACCTGGAATGGGCCCAGGGTGACAGTT
ATAATAAGTGTTTGTCAAGTGAGCAAGTGTGTGGAGTGTGCATTGTAGAGAGTAAGGTCTCTACAGGATCCTGCTGGAGAGGCAGCCCAC
TGGGCTCACCACTTCTCCAGAGGAGGGACTGGTCCCTTGCCAGACAGCCCTGCCAGCTGGAGCAGGCTTCCTCAGGGGTGCCTGGAGCTG


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FusionGenePPI for RAD50_C5orf56


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAD50HNF4A, H2AFX, BLM, BRCA1, MRE11A, NBN, ATM, MLH1, MSH2, MSH6, RFC1, TERF2, TERF2IP, MDC1, RINT1, CHEK2, RECQL5, USP11, USP42, USP53, DDX1, PHF1, PAXIP1, GEMIN2, DCLRE1B, KAT5, TERF1, HDAC5, EP300, BARD1, RBBP8, SMARCAD1, SKP2, SIRT7, HNRNPA1, MDM2, TFAP4, DCLRE1C, NOP56, NCSTN, HNRNPR, RBL2, RNF8, PAN2, FBXO6, RPA1, RPA2, RPA3, PASK, ATRX, CUL7, OBSL1, EED, RNF2, SUMO2, SIRT6, ILF2, ILF3, MCM5, ZNF511, MAF1, ZFAND2B, CELA2B, LRRC39, FAM219A, MDM4, CHAMP1, SMC5, NTRK1, SCARNA22, MED23, OFD1, FGFR1OP, CEP128, RPGRIP1L, HIST1H3E, HSF2, SLC33A1, TMEM132A, GLI1, FOXL1, USP4, ESR1, SNW1, CDC5L, RNF126, NFATC2, HIST3H3, DUSP23, DUSP28, RGS20, BMP1, ATG14, RAB39B, HS1BP3, FAM196A, RAD50, C15orf26, CCDC150, BRIP1, SPTA1, DLST, HDAC6, MCM9, MCM8C5orf56


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAD50_C5orf56


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAD50_C5orf56


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAD50C0004096Asthma1CTD_human