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Fusion gene ID: 30159 |
FusionGeneSummary for RAD21_TPM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD21_TPM2 | Fusion gene ID: 30159 | Hgene | Tgene | Gene symbol | RAD21 | TPM2 | Gene ID | 5885 | 7169 |
| Gene name | RAD21 cohesin complex component | tropomyosin 2 | |
| Synonyms | CDLS4|HR21|HRAD21|MCD1|NXP1|SCC1|hHR21 | AMCD1|DA1|DA2B|HEL-S-273|NEM4|TMSB | |
| Cytomap | 8q24.11 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | double-strand-break repair protein rad21 homologNXP-1RAD21 homologSCC1 homologkleisinnuclear matrix protein 1protein involved in DNA double-strand break repairsister chromatid cohesion 1 | tropomyosin beta chainepididymis secretory protein Li 273nemaline myopathy type 4tropomyosin 2 (beta) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60216 | P07951 | |
| Ensembl transtripts involved in fusion gene | ENST00000297338, ENST00000523986, ENST00000517749, ENST00000518055, ENST00000523547, | ENST00000378300, ENST00000378292, ENST00000329305, ENST00000360958, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 8 X 2=128 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/128*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAD21 [Title/Abstract] AND TPM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD21 | GO:0006357 | regulation of transcription by RNA polymerase II | 19468298 |
| Tgene | TPM2 | GO:0043462 | regulation of ATPase activity | 17194691 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-KD-A5QU-01A | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000297338 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| In-frame | ENST00000297338 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| In-frame | ENST00000297338 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| In-frame | ENST00000297338 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
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FusionProtFeatures for RAD21_TPM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD21 | TPM2 |
| Cleavable component of the cohesin complex, involved inchromosome cohesion during cell cycle, in DNA repair, and inapoptosis. The cohesin complex is required for the cohesion ofsister chromatids after DNA replication. The cohesin complexapparently forms a large proteinaceous ring within which sisterchromatids can be trapped. At metaphase-anaphase transition, thisprotein is cleaved by separase/ESPL1 and dissociates fromchromatin, allowing sister chromatids to segregate. The cohesincomplex may also play a role in spindle pole assembly duringmitosis. Also plays a role in apoptosis, via its cleavage bycaspase-3/CASP3 or caspase-7/CASP7 during early steps ofapoptosis: the C-terminal 64 kDa cleavage product may act as anuclear signal to initiate cytoplasmic events involved in theapoptotic pathway. {ECO:0000269|PubMed:11875078,ECO:0000269|PubMed:12417729}. | Binds to actin filaments in muscle and non-muscle cells.Plays a central role, in association with the troponin complex, inthe calcium dependent regulation of vertebrate striated musclecontraction. Smooth muscle contraction is regulated by interactionwith caldesmon. In non-muscle cells is implicated in stabilizingcytoskeleton actin filaments. The non-muscle isoform may have arole in agonist-mediated receptor internalization.{ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAD21 | chr8:117862857 | chr9:35685548 | ENST00000297338 | - | 12 | 14 | 469_510 | 540 | 632 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TPM2 | chr8:117862857 | chr9:35685548 | ENST00000360958 | - | 2 | 9 | 1_284 | 124 | 285 | Coiled coil | Ontology_term=ECO:0000250 |
| Tgene | TPM2 | chr8:117862857 | chr9:35685548 | ENST00000378292 | - | 2 | 9 | 1_284 | 124 | 285 | Coiled coil | Ontology_term=ECO:0000250 |
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FusionGeneSequence for RAD21_TPM2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000378300_chr9_35685548_-_738aa MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE RNEGHRKPGHEGXGEDGTAGDAAEGGQAHRXGFRPQIXRGGQEAGDPGRRAGALGGEGXGGREXMWGPRGGAENCYQQLEIPGGPGGQVF HQRRXIXRGDQTVGGEAEGGXDPSRVCREVCGKVGENHRXPRREHLYRHHGALVHSXHPGTYXHPQPLHXAHPQNTMAHAETPLHRHSLA >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000378292_chr9_35685548_-_700aa MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE RNEGHRKPGHEGXGEDGTAGDAAEGGQAHRXGFRPQIXRGGQEAGDPGRRAGALGGEGXGGREPSQTAGGGTSNHGPGPQVPDGLRGGVF >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000329305_chr9_35685548_-_700aa MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE RNEGHRKPGHEGXGEDGTAGDAAEGGQAHRXGFRPQIXRGGQEAGDPGRRAGALGGEGXGGREXMWGPRGGAENCYQQLEIPGGPGGQVF >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000360958_chr9_35685548_-_700aa MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE RNEGHRKPGHEGXGEDGTAGDAAEGGQAHRXGFRPQIXRGGQEAGDPGRRAGALGGEGXGGREXMWGPRGGAENCYQQLEIPGGPGGQVF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000378300_chr9_35685548_-_2215nt ATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGATAAGAAGCTAACCAAAGCC CATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGGACATCAGGACATCTCTTA CTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAGATAAAGATGGCTTTTCGG CCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTTCATGACTTTGATCAGCCA CTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACCATGAGAGAAGAAGTTGGG AACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCTTTTGAGGATGAC GACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAGAAAATTAACCATTTAGAA TATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATTAGTAATAATGATGGCGGT ATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATGGATGAGGATGATAATGTA TCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACACTTGTTCCAAATGAG GAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTAATTGTTGACAGTGTCAAA GAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCACCGCCCACCAAGAAATTG ATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGACTACTGAAGCTCTTTACA CGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGATGAATTCCTCAAAGAATTT GAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATTATTGAAGAGCCAAGCCGC CTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCGAAAAGCT GGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTTCCCCCAGAAGAACCTCCA AATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAAGATGATGAAGAGGAAGAG AGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAAGGAGGCCAAGCACATCGC TGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTCGGAGGAGAGGGCTGAGGT GGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGCCCAGGCGGACAAGTATTC CACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGCAGAGTTTGCCGAGAGGTC TGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGAGCACCTCTATCGCCACCACGGAGCACTGGTTCACTCCTGACACCCTGGC ACTTACTGACACCCCCAGCCCCTGCACTGAGCCCACCCACAAAACACCATGGCCCACGCTGAAACCCCTCTGCACAGGCACTCCCTGGCT >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000378292_chr9_35685548_-_2101nt ATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGATAAGAAGCTAACCAAAGCC CATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGGACATCAGGACATCTCTTA CTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAGATAAAGATGGCTTTTCGG CCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTTCATGACTTTGATCAGCCA CTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACCATGAGAGAAGAAGTTGGG AACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCTTTTGAGGATGAC GACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAGAAAATTAACCATTTAGAA TATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATTAGTAATAATGATGGCGGT ATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATGGATGAGGATGATAATGTA TCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACACTTGTTCCAAATGAG GAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTAATTGTTGACAGTGTCAAA GAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCACCGCCCACCAAGAAATTG ATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGACTACTGAAGCTCTTTACA CGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGATGAATTCCTCAAAGAATTT GAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATTATTGAAGAGCCAAGCCGC CTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCGAAAAGCT GGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTTCCCCCAGAAGAACCTCCA AATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAAGATGATGAAGAGGAAGAG AGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAAGGAGGCCAAGCACATCGC TGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTCGGAGGAGAGGGCTGAGGT GGCCGAGAGCCGAGCCAGACAGCTGGAGGAGGAACTTCGAACCATGGACCAGGCCCTCAAGTCCCTGATGGCCTCAGAGGAGGAGTATTC CACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGCAGAGTTTGCCGAGAGGTC TGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGACCTTGGCCAGTGCCAAGGAGGAGAACGTCGAGATTCACCAGACCTTGGA >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000329305_chr9_35685548_-_2101nt ATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGATAAGAAGCTAACCAAAGCC CATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGGACATCAGGACATCTCTTA CTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAGATAAAGATGGCTTTTCGG CCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTTCATGACTTTGATCAGCCA CTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACCATGAGAGAAGAAGTTGGG AACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCTTTTGAGGATGAC GACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAGAAAATTAACCATTTAGAA TATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATTAGTAATAATGATGGCGGT ATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATGGATGAGGATGATAATGTA TCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACACTTGTTCCAAATGAG GAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTAATTGTTGACAGTGTCAAA GAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCACCGCCCACCAAGAAATTG ATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGACTACTGAAGCTCTTTACA CGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGATGAATTCCTCAAAGAATTT GAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATTATTGAAGAGCCAAGCCGC CTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCGAAAAGCT GGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTTCCCCCAGAAGAACCTCCA AATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAAGATGATGAAGAGGAAGAG AGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAAGGAGGCCAAGCACATCGC TGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTCGGAGGAGAGGGCTGAGGT GGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGCCCAGGCGGACAAGTATTC CACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGCAGAGTTTGCCGAGAGGTC TGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGACCTTGGCCAGTGCCAAGGAGGAGAACGTCGAGATTCACCAGACCTTGGA >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000360958_chr9_35685548_-_2101nt ATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGATAAGAAGCTAACCAAAGCC CATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGGACATCAGGACATCTCTTA CTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAGATAAAGATGGCTTTTCGG CCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTTCATGACTTTGATCAGCCA CTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACCATGAGAGAAGAAGTTGGG AACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCTTTTGAGGATGAC GACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAGAAAATTAACCATTTAGAA TATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATTAGTAATAATGATGGCGGT ATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATGGATGAGGATGATAATGTA TCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACACTTGTTCCAAATGAG GAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTAATTGTTGACAGTGTCAAA GAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCACCGCCCACCAAGAAATTG ATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGACTACTGAAGCTCTTTACA CGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGATGAATTCCTCAAAGAATTT GAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATTATTGAAGAGCCAAGCCGC CTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCGAAAAGCT GGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTTCCCCCAGAAGAACCTCCA AATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAAGATGATGAAGAGGAAGAG AGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAAGGAGGCCAAGCACATCGC TGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTCGGAGGAGAGGGCTGAGGT GGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGCCCAGGCGGACAAGTATTC CACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGCAGAGTTTGCCGAGAGGTC TGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGATGAAGTCTATGCCCAGAAGATGAAGTACAAGGCCATTAGCGAGGAACTGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000378300_chr9_35685548_-_3219nt AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC GGAGGAGAGGGCTGAGGTGGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGC CCAGGCGGACAAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGAGCACCTCTATCGCCACCACGGAGCACTGGTT CACTCCTGACACCCTGGCACTTACTGACACCCCCAGCCCCTGCACTGAGCCCACCCACAAAACACCATGGCCCACGCTGAAACCCCTCTG CACAGGCACTCCCTGGCTGTCGCTCTCTGATTCACCACTGCATGTGGGCACGTGTGGCCCCATCAAACCATGACCGCCTCTGGTGCCAAT CCCTGACCTCAGAGCACTTAGCTGGGGTTCCAGGATCAAACAGAGTGACTGGAAAGGAAGTAGGGTGGTGAGGTGCAGGACAGGGGCAAG AAGGTTGCAAAAGGTCTGGAATGGAGCTTGGAAAAATGTTGGATATCAGCAACATGGGGCTTTCACTGCAGCAGCAGGTCTGTTTTCTAC CTCAAGTCTGTCTGTCTGGCCCTTCCTTTCCTGGCGCAGTCTTTGTCTTACCTTCTGTCTCCAACTTCCTTAAACCTTCTAAAGAAGAGG ATAAAGTAGTTTATGACTCAGCCCTCCCCACCCCACCTCTATGACCCCAAGGCCTTGAGTGAGGCATCCACGTCCGTCCTGTTCCCCTCA TCCTAGTCAGTCCATCTGTTTGTCCCTGCCAAGGGGCCCTGAGGTCCGTGAATGCATGTGTCTTCCTTGACCCACTCCATGTCTATATGT CACCTTCCCCTGGCCCTGCCTCCCCACGTCTCCCCCTTGTGTCTCCCTTCTCCCTCACCTGCTGCTTCCCCTCACAGAGACCTTGGCCAG TGCCAAGGAGGAGAACGTCGAGATTCACCAGACCTTGGACCAGACCCTGCTGGAACTCAACAACCTGTGAGGGCCAGCCCCACCCCCAGC >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000378292_chr9_35685548_-_2478nt AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC GGAGGAGAGGGCTGAGGTGGCCGAGAGCCGAGCCAGACAGCTGGAGGAGGAACTTCGAACCATGGACCAGGCCCTCAAGTCCCTGATGGC CTCAGAGGAGGAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGACCTTGGCCAGTGCCAAGGAGGAGAACGTCGA GATTCACCAGACCTTGGACCAGACCCTGCTGGAACTCAACAACCTGTGAGGGCCAGCCCCACCCCCAGCCAGGCTATGGTTGCCACCCCA >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000329305_chr9_35685548_-_2456nt AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC GGAGGAGAGGGCTGAGGTGGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGC CCAGGCGGACAAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGACCTTGGCCAGTGCCAAGGAGGAGAACGTCGA GATTCACCAGACCTTGGACCAGACCCTGCTGGAACTCAACAACCTGTGAGGGCCAGCCCCACCCCCAGCCAGGCTATGGTTGCCACCCCA >In-frame_RAD21_ENST00000297338_chr8_117862857_-_TPM2_ENST00000360958_chr9_35685548_-_2618nt AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC GGAGGAGAGGGCTGAGGTGGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGC CCAGGCGGACAAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGATGAAGTCTATGCCCAGAAGATGAAGTACAAGGC CATTAGCGAGGAACTGGACAACGCACTCAATGACATCACCTCCCTCTGAGCCCCACGCCAGCGTGGCCACCTCAGCTCTCTTCTCTCCTC TCCTTTCCATTCTCTCTATGGGGAGGGGAGCAGGCAGGAGGAGCAGAAATTGCCAACATTGCACAGCCAGGCTGGGAGCAGCCTAGGGAG AGCCCCCATCATGCCCACCACCCACTCTGGCACTGGCTTCATCCTTTACCTATCCCCTTCCACCCTCCTTTGCTGCTTAATAAATTCTGA |
Top |
FusionGenePPI for RAD21_TPM2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAD21 | CHTF18, SMARCA5, CHD3, SMC1A, STAG1, AIRE, CDCA5, SRRM1, CTCF, SSU72, STAG2, SMC3, PDS5A, WFDC5, PDS5B, WAPAL, DISC1, CDC34, RPL13, RPL10, WNT2B, HNRNPH2, PPP1R15B, PPP1R15A, DAPK3, ZNF80, TNFRSF14, TMSB4X, COX2, IL7R, CSTB, FLNB, CFL1, MSRB2, FHL3, DYNLT1, RPL35A, PHACTR4, UBC, TPM3, KPNB1, CCDC170, UBA1, DDB1, MCM2, EWSR1, CCAR2, XIRP2, CALML5, DEK, THSD7A, SMR3B, ALYREF, CTTNBP2, TPR, MCM7, MCM3, MCM4, PCNA, PGK1, EVX1, CHD4, PPM1D, SMC2, NCAPG, MTA3, TMPO, FEN1, CUL4A, RPS27A, EIF3A, YBX1, RPS3, GAPVD1, RPL5, EIF3C, GTPBP1, UBE2O, RPS4X, EIF4A1, EIF2S3, HSP90AA1, RPS18, FASN, CAD, EIF3B, TUBB4B, RPS14, EIF4G1, CTPS1, CCT7, RNF123, PFKL, RPS2, RPL23A, HSD17B8, SYNCRIP, SEPT1, RPS25, SMC4, RPS16, RPS7, CDKN2AIP, PSPC1, RPS26P11, RPL11, DNAJB4, SARS2, SKIV2L2, CBR1, EIF2S1, API5, RPS19, RPS15A, RPS20, RPS13, NCAPD2, RPS11, RPS3A, DDX3X, RPL23, ACTR3, CLASP2, CDK9, RAN, RPS6, PSMC1, TOP3A, DIP2B, ACAT1, RPL6, RPL22, PSMD2, CAPN1, NACA, SETD3, RPL30, CCT2, AMPD3, GNL1, FOCAD, OLA1, EIF3D, EIF3F, RPS10, EVL, RPL13P12, CTTN, NAA15, UBE3C, RPL22L1, RPS5, OSBP, RPL17, CCT3, EIF3I, RPS17, G3BP1, LRPPRC, NAP1L1, RFC3, PRKDC, CPS1, HSP90AB1, TRAP1, HIST1H1D, CSTA, CCT8, ARG1, EEF1D, DHX9, KIF3B, SFPQ, CP, ITGAM, TCF15, TRAIP, PIGR, C1QBP, HNRNPA3, YEATS2, STX10, OR1E2, MPO, SERPINB1, TFG, C3, UBE2L6, NPAT, HNRNPU, APOB, CLU, CCDC7, PDZD2, ANAPC4, CTSG, S100A9, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4J, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4, AZU1, UBA52, CALML3, HIST1H1B, H2AFJ, RNASE3, AHSP, MYC, SIRT7, NSMCE2, SNW1, PIN4, MEA1, MSH2, SF3A3, NIPBL, ANKRD28, HECW2, RPA3, RPA2, RPA1, BRCA1, EED, RNF2, SIRT6, PSMC2, THBS3, PIP5K1A, BRCA2, UNK, MSH6, SMC1B, NTRK1, HIST1H3E, RPS21, MIER1, MUC16, USP37, USP13, CCDC102B, SUCLA2, TOR1AIP2, BMP1, CPNE5, CCM2, AARSD1, ARPC5, USP47, ACTBL2, COMMD1 | TPM2 | TPM2, PDLIM7, RRAD, TPM1, ACTA1, SP1, LRRK2, AKT1, TPM4, AHCYL1, TPM3, STMN1, SRXN1, SF3B2, DDB1, NONO, DSTN, CORO1B, SULT1A1, STAM, CPSF7, TAF15, DYNC1H1, DDX46, DDX3X, SKIL, HECTD1, RPA3, RPA2, RPA1, MAGEA10, EBNA1BP2, FAM189B, C11orf70, ASPDH, CDK5R1, CIART, ZNF250, NEB, ACTN1, ACTN4, CKMT1B, CKMT1A, PSMD5, ACTN2, ATP5F1, BCAP31, CAPZB, CCAR1, COX4I1, MYH3, MYH6, MYH7, MYL6, NDUFB10, SLC4A1AP, SSB, SUB1, TNNI1, UQCRC2, ADD1, CAPZA2, CDK2, FLNA, MYH9, PPP1CB, MAPK3, IQGAP1, SYNPO, ANLN, MYO5C, MYO19, MYO18A, RBPJ, RC3H1, SLC25A48, TIMM44, PCGF2, CFHR3, TMEM205, WAC, ZNF22, HIST1H1T, FAM60A, AKT2, C1orf43, ZNF704, SEMA6D, ATAD1, RRM2B, LGALS9C, C17orf105, STOX1, POC1B, STK17B, HAS3, POTEB3, RHOBTB2, SEPT2, KANSL1, POF1B, AGBL2, SLC47A1, YIPF1, PDLIM5, AKAP9, NINL, PKIG, CCDC51, SCG3, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | RAD21 | chr8:117862857 | chr9:35685548 | ENST00000297338 | - | 12 | 14 | 362_403 | 540 | 632 | STAG1 |
| Hgene | RAD21 | chr8:117862857 | chr9:35685548 | ENST00000297338 | - | 12 | 14 | 287_403 | 540 | 632 | WAPL and PDS5B |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAD21_TPM2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAD21_TPM2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RAD21 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Hgene | RAD21 | C1860789 | Leukemia, Megakaryoblastic, of Down Syndrome | 1 | CTD_human |
| Hgene | RAD21 | C3553517 | CORNELIA DE LANGE SYNDROME 4 | 1 | UNIPROT |
| Tgene | TPM2 | C1836447 | Nemaline myopathy 4 | 4 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TPM2 | C0220662 | ARTHROGRYPOSIS, DISTAL, TYPE 1 | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TPM2 | C1834523 | ARTHROGRYPOSIS, DISTAL, TYPE 2B | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TPM2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
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