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Fusion gene ID: 30145 |
FusionGeneSummary for RAC3_ABCA8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAC3_ABCA8 | Fusion gene ID: 30145 | Hgene | Tgene | Gene symbol | RAC3 | ABCA8 | Gene ID | 8202 | 10351 |
| Gene name | nuclear receptor coactivator 3 | ATP binding cassette subfamily A member 8 | |
| Synonyms | ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP | - | |
| Cytomap | 20q13.12 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1 | ATP-binding cassette sub-family A member 8ATP-binding cassette, sub-family A (ABC1), member 8 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P60763 | O94911 | |
| Ensembl transtripts involved in fusion gene | ENST00000306897, | ENST00000269080, ENST00000430352, ENST00000586539, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 2=24 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAC3 [Title/Abstract] AND ABCA8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAC3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9267036 |
| Hgene | RAC3 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AQ-A04H-01B | RAC3 | chr17 | 79989672 | + | ABCA8 | chr17 | 66865920 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000306897 | ENST00000269080 | RAC3 | chr17 | 79989672 | + | ABCA8 | chr17 | 66865920 | - |
| In-frame | ENST00000306897 | ENST00000430352 | RAC3 | chr17 | 79989672 | + | ABCA8 | chr17 | 66865920 | - |
| In-frame | ENST00000306897 | ENST00000586539 | RAC3 | chr17 | 79989672 | + | ABCA8 | chr17 | 66865920 | - |
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FusionProtFeatures for RAC3_ABCA8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAC3 | ABCA8 |
| Plasma membrane-associated small GTPase which cyclesbetween an active GTP-bound and inactive GDP-bound state. Inactive state binds to a variety of effector proteins to regulatecellular responses, such as cell spreading and the formation ofactin-based protusions including lamellipodia and membraneruffles. Promotes cell adhesion and spreading on fibrinogen in aCIB1 and alpha-IIb/beta3 integrin-mediated manner.{ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}. | ATP-dependent lipophilic drug transporter.{ECO:0000269|PubMed:12379217}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RAC3 | chr17:79989672 | chr17:66865920 | ENST00000306897 | + | 1 | 6 | 32_40 | 11 | 193 | Motif | Effector region |
| Hgene | >RAC3 | chr17:79989672 | chr17:66865920 | ENST00000306897 | + | 1 | 6 | 10_17 | 11 | 193 | Nucleotide binding | GTP |
| Hgene | >RAC3 | chr17:79989672 | chr17:66865920 | ENST00000306897 | + | 1 | 6 | 115_118 | 11 | 193 | Nucleotide binding | GTP |
| Hgene | >RAC3 | chr17:79989672 | chr17:66865920 | ENST00000306897 | + | 1 | 6 | 57_61 | 11 | 193 | Nucleotide binding | GTP |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1245_1478 | 1503 | 1582 | Domain | ABC transporter 2 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 480_675 | 1503 | 1582 | Domain | ABC transporter 1 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1245_1478 | 1543 | 1622 | Domain | ABC transporter 2 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 480_675 | 1543 | 1622 | Domain | ABC transporter 1 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1283_1290 | 1503 | 1582 | Nucleotide binding | ATP 2 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 516_523 | 1503 | 1582 | Nucleotide binding | ATP 1 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1283_1290 | 1543 | 1622 | Nucleotide binding | ATP 2 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 516_523 | 1543 | 1622 | Nucleotide binding | ATP 1 |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1030_1050 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1066_1086 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1096_1116 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1121_1141 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 1157_1177 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 220_240 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 268_288 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 299_319 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 30_50 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 327_347 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 359_379 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 397_417 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 824_844 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000269080 | - | 34 | 38 | 979_999 | 1503 | 1582 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1030_1050 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1066_1086 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1096_1116 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1121_1141 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 1157_1177 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 220_240 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 268_288 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 299_319 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 30_50 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 327_347 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 359_379 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 397_417 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 824_844 | 1543 | 1622 | Transmembrane | Helical |
| Tgene | ABCA8 | chr17:79989672 | chr17:66865920 | ENST00000430352 | - | 34 | 38 | 979_999 | 1543 | 1622 | Transmembrane | Helical |
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FusionGeneSequence for RAC3_ABCA8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000269080_chr17_66865920_-_90aa MQAIKCVVVGDGYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEEPX >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000430352_chr17_66865920_-_90aa MQAIKCVVVGDGYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEEPX >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000586539_chr17_66865920_-_90aa MQAIKCVVVGDGYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEEPX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000269080_chr17_66865920_-_270nt ATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGGTACTCCTCTCTGATGGTTTATAAGTTGCCAGTGGAAGATGTGCAACCTTTAGCC CAAGCTTTCTTCAAATTAGAGAAGGTTAAACAGAGCTTTGACCTAGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAGGTTTTCCTG GAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGATTTTGATCCCTCAGTGAAGTGGAAGCTCCTCCCCCAGGAAGAGCCTTAA >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000430352_chr17_66865920_-_270nt ATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGGTACTCCTCTCTGATGGTTTATAAGTTGCCAGTGGAAGATGTGCAACCTTTAGCC CAAGCTTTCTTCAAATTAGAGAAGGTTAAACAGAGCTTTGACCTAGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAGGTTTTCCTG GAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGATTTTGATCCCTCAGTGAAGTGGAAGCTCCTCCCCCAGGAAGAGCCTTAA >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000586539_chr17_66865920_-_270nt ATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGGTACTCCTCTCTGATGGTTTATAAGTTGCCAGTGGAAGATGTGCAACCTTTAGCC CAAGCTTTCTTCAAATTAGAGAAGGTTAAACAGAGCTTTGACCTAGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAGGTTTTCCTG GAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGATTTTGATCCCTCAGTGAAGTGGAAGCTCCTCCCCCAGGAAGAGCCTTAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000269080_chr17_66865920_-_1201nt GTCTCCGCGCCCGGCGCTCGGCGGCGCTCGGCTGTCTCCGGCCGATCGCTCGGCGCTCGGGTCCGCGGCCGCTGCGGCGCCGGGCATTTC TCCGCAGCTCGGCTCGCGGCCGCGCCCGCCGCCGCCCGGCCCGCGCCCATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGGTACTCC TCTCTGATGGTTTATAAGTTGCCAGTGGAAGATGTGCAACCTTTAGCCCAAGCTTTCTTCAAATTAGAGAAGGTTAAACAGAGCTTTGAC CTAGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAGGTTTTCCTGGAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGAT TTTGATCCCTCAGTGAAGTGGAAGCTCCTCCCCCAGGAAGAGCCTTAAAACCCCAAATTCTGTGTTCCTGTTTAAACCCGTGGTTTTTTT TAAATACATTTATTTTTATAGCAGCAATGTTCTATTTTTAGAAACTATATTATAAGTACAGAAATGGTTCTCCGTGTGGTGGGAGGAGGA GGTTCGGGTGCTGGGTAAGTGCCATGTCAGTGTGGACAGAGGCATTTGACTAAGCCAACCTCCTCTCACAGCCTCTGTATCTCTGCAGGC CATACTGGTTCCATTGTTCTGTATAATACTGAATAAATAAATTTACTTTTACATGATCGTATAAGTTTCTAGATAAGATAAACAAATTTT GTTTAAATTTTTTTAATAAAAATCTTAAAACACTTTTTTTCTAACCTAGACTGAGAAATTCATGTTTACTTTTCTAGGTGTATGATACTT TGTAAAGTTGATACTTTCCTAAGAATTTAACATGTCATATTTTTGAAATAGATTTAAGTGTGCTTCTTATTGCTAAAAATACTAAATGTC ATGGGTCATAGTATCTGATATCAATATCGTTGATAACATATCCACAGGTAACACCATGATGTAGGCATAAATGGAAAACAAAAACCCTAC TATTTCAAATATATTGTACTTTTTTATTTCTGTAAGCCAACTGTGTGCCATTTTCACTGGACTTTTAAATCTAGACTTTAGTGATGTCTA CATTGTAAATGATCTTTTGTGGATATTTGTCACTTGGTTTCAGAAAGTTCACAAATGTAGCAACAGCTCACATGACTGAGTAGGTAGAAA >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000430352_chr17_66865920_-_441nt GTCTCCGCGCCCGGCGCTCGGCGGCGCTCGGCTGTCTCCGGCCGATCGCTCGGCGCTCGGGTCCGCGGCCGCTGCGGCGCCGGGCATTTC TCCGCAGCTCGGCTCGCGGCCGCGCCCGCCGCCGCCCGGCCCGCGCCCATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGGTACTCC TCTCTGATGGTTTATAAGTTGCCAGTGGAAGATGTGCAACCTTTAGCCCAAGCTTTCTTCAAATTAGAGAAGGTTAAACAGAGCTTTGAC CTAGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAGGTTTTCCTGGAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGAT >In-frame_RAC3_ENST00000306897_chr17_79989672_+_ABCA8_ENST00000586539_chr17_66865920_-_441nt GTCTCCGCGCCCGGCGCTCGGCGGCGCTCGGCTGTCTCCGGCCGATCGCTCGGCGCTCGGGTCCGCGGCCGCTGCGGCGCCGGGCATTTC TCCGCAGCTCGGCTCGCGGCCGCGCCCGCCGCCGCCCGGCCCGCGCCCATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGGTACTCC TCTCTGATGGTTTATAAGTTGCCAGTGGAAGATGTGCAACCTTTAGCCCAAGCTTTCTTCAAATTAGAGAAGGTTAAACAGAGCTTTGAC CTAGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAGGTTTTCCTGGAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGAT |
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FusionGenePPI for RAC3_ABCA8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAC3 | CIB1, ARHGDIB, ARHGDIA, ESR1, FBXL19, RHOC, DUSP9, RAC2, RAC1, RAP1GDS1, SLC7A1, SLC9A6 | ABCA8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAC3_ABCA8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAC3_ABCA8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ABCA8 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
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