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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30107

FusionGeneSummary for RABEPK_RABEPK

check button Fusion gene summary
Fusion gene informationFusion gene name: RABEPK_RABEPK
Fusion gene ID: 30107
HgeneTgene
Gene symbol

RABEPK

RABEPK

Gene ID

10244

10244

Gene nameRab9 effector protein with kelch motifsRab9 effector protein with kelch motifs
SynonymsRAB9P40|bA65N13.1|p40RAB9P40|bA65N13.1|p40
Cytomap

9q33.3

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionrab9 effector protein with kelch motifs40 kDa Rab9 effector proteinRab9 effector p40rab9 effector protein with kelch motifs40 kDa Rab9 effector proteinRab9 effector p40
Modification date2018051920180519
UniProtAcc

Q7Z6M1

Q7Z6M1

Ensembl transtripts involved in fusion geneENST00000259460, ENST00000394125, 
ENST00000373544, ENST00000394124, 
ENST00000373538, 		ENST00000259460, 
ENST00000394125, ENST00000373544, 
ENST00000394124, ENST00000373538, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: RABEPK [Title/Abstract] AND RABEPK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF205330RABEPKchr9

127994885

-RABEPKchr9

127994946

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000259460ENST00000259460RABEPKchr9

127994885

-RABEPKchr9

127994946

+
In-frameENST00000259460ENST00000394125RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-intronENST00000259460ENST00000373544RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-3UTRENST00000259460ENST00000394124RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-3UTRENST00000259460ENST00000373538RABEPKchr9

127994885

-RABEPKchr9

127994946

+
In-frameENST00000394125ENST00000259460RABEPKchr9

127994885

-RABEPKchr9

127994946

+
In-frameENST00000394125ENST00000394125RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-intronENST00000394125ENST00000373544RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-3UTRENST00000394125ENST00000394124RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-3UTRENST00000394125ENST00000373538RABEPKchr9

127994885

-RABEPKchr9

127994946

+
intron-3CDSENST00000373544ENST00000259460RABEPKchr9

127994885

-RABEPKchr9

127994946

+
intron-3CDSENST00000373544ENST00000394125RABEPKchr9

127994885

-RABEPKchr9

127994946

+
intron-intronENST00000373544ENST00000373544RABEPKchr9

127994885

-RABEPKchr9

127994946

+
intron-3UTRENST00000373544ENST00000394124RABEPKchr9

127994885

-RABEPKchr9

127994946

+
intron-3UTRENST00000373544ENST00000373538RABEPKchr9

127994885

-RABEPKchr9

127994946

+
3UTR-3CDSENST00000394124ENST00000259460RABEPKchr9

127994885

-RABEPKchr9

127994946

+
3UTR-3CDSENST00000394124ENST00000394125RABEPKchr9

127994885

-RABEPKchr9

127994946

+
3UTR-intronENST00000394124ENST00000373544RABEPKchr9

127994885

-RABEPKchr9

127994946

+
3UTR-3UTRENST00000394124ENST00000394124RABEPKchr9

127994885

-RABEPKchr9

127994946

+
3UTR-3UTRENST00000394124ENST00000373538RABEPKchr9

127994885

-RABEPKchr9

127994946

+
In-frameENST00000373538ENST00000259460RABEPKchr9

127994885

-RABEPKchr9

127994946

+
In-frameENST00000373538ENST00000394125RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-intronENST00000373538ENST00000373544RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-3UTRENST00000373538ENST00000394124RABEPKchr9

127994885

-RABEPKchr9

127994946

+
5CDS-3UTRENST00000373538ENST00000373538RABEPKchr9

127994885

-RABEPKchr9

127994946

+

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FusionProtFeatures for RABEPK_RABEPK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RABEPK

Q7Z6M1

RABEPK

Q7Z6M1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RABEPK_RABEPK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RABEPK_RABEPK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RABEPK_RABEPK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RABEPK_RABEPK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource