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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3010

FusionGeneSummary for ASNA1_RLN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ASNA1_RLN3
Fusion gene ID: 3010
HgeneTgene
Gene symbol

ASNA1

RLN3

Gene ID

439

117579

Gene namearsA arsenite transporter, ATP-binding, homolog 1 (bacterial)relaxin 3
SynonymsARSA-I|ARSA1|ASNA-I|GET3|TRC40H3|RXN3|ZINS4|insl7
Cytomap

19p13.13

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionATPase ASNA1golgi to ER traffic 3 homologtransmembrane domain recognition complex 40 kDa ATPase subunitrelaxin-3insulin-like peptide 7insulin-like peptide INSL7prorelaxin H3
Modification date2018052320180523
UniProtAcc

O43681

Q8WXF3

Ensembl transtripts involved in fusion geneENST00000591090, ENST00000357332, 
ENST00000431365, ENST00000585987, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 1 X 9=27
# samples 510
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/27*10)=1.88896868761126
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASNA1 [Title/Abstract] AND RLN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-25-1319-01AASNA1chr19

12849472

+RLN3chr19

14141522

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000591090ENST00000431365ASNA1chr19

12849472

+RLN3chr19

14141522

+
Frame-shiftENST00000591090ENST00000585987ASNA1chr19

12849472

+RLN3chr19

14141522

+
Frame-shiftENST00000357332ENST00000431365ASNA1chr19

12849472

+RLN3chr19

14141522

+
Frame-shiftENST00000357332ENST00000585987ASNA1chr19

12849472

+RLN3chr19

14141522

+

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FusionProtFeatures for ASNA1_RLN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASNA1

O43681

RLN3

Q8WXF3

ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer revertstowards the open dimer state, lowering its affinity for themembrane-bound receptor, and returning it to the cytosol toinitiate a new round of targeting (By similarity). May be involvedin insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112,ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612,ECO:0000269|PubMed:25535373}. May play a role in neuropeptide signaling processes.Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3receptor-2 (GPCR142).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASNA1_RLN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASNA1_RLN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASNA1UBL4A, CACNA1A, TK1, TTR, PFDN1, UBE2J1, SEC61B, SEC61A1, VAMP2, STX5, BAG6, EIF6, HSPA8, RARS, RUVBL2, TUBB, VAPB, FAF1, UBC, APLN, STATH, SGTA, HUWE1, ASPH, GPX7, HILPDA, CUL7, GET4, RNF126, DNAJB2, PSMB1, PSMB2, PSMB3, PSMB5, PSMB6, TARBP1, PSMA2, PSMA4, NTRK1, OTUB1, CAMLG, WRB, ZNF579, ASPSCR1, NUDT9, CCND2RLN3RXFP4, RXFP1, RXFP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASNA1_RLN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASNA1_RLN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRLN3C0020507Hyperplasia1CTD_human
TgeneRLN3C0151744Myocardial Ischemia1CTD_human