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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3007

FusionGeneSummary for ASNA1_DHPS

check button Fusion gene summary
Fusion gene informationFusion gene name: ASNA1_DHPS
Fusion gene ID: 3007
HgeneTgene
Gene symbol

ASNA1

DHPS

Gene ID

439

1725

Gene namearsA arsenite transporter, ATP-binding, homolog 1 (bacterial)deoxyhypusine synthase
SynonymsARSA-I|ARSA1|ASNA-I|GET3|TRC40DHS|DS|MIG13
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
DescriptionATPase ASNA1golgi to ER traffic 3 homologtransmembrane domain recognition complex 40 kDa ATPase subunitdeoxyhypusine synthasemigration-inducing gene 13
Modification date2018052320180523
UniProtAcc

O43681

P49366

Ensembl transtripts involved in fusion geneENST00000591090, ENST00000357332, 
ENST00000210060, ENST00000351660, 
ENST00000594424, ENST00000599481, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 2=18
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASNA1 [Title/Abstract] AND DHPS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDHPS

GO:0008216

spermidine metabolic process

23525104

TgeneDHPS

GO:0008612

peptidyl-lysine modification to peptidyl-hypusine

23525104


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-PG-A7D5-01AASNA1chr19

12849472

+DHPSchr19

12791139

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000591090ENST00000210060ASNA1chr19

12849472

+DHPSchr19

12791139

-
In-frameENST00000591090ENST00000351660ASNA1chr19

12849472

+DHPSchr19

12791139

-
In-frameENST00000591090ENST00000594424ASNA1chr19

12849472

+DHPSchr19

12791139

-
5CDS-5UTRENST00000591090ENST00000599481ASNA1chr19

12849472

+DHPSchr19

12791139

-
In-frameENST00000357332ENST00000210060ASNA1chr19

12849472

+DHPSchr19

12791139

-
In-frameENST00000357332ENST00000351660ASNA1chr19

12849472

+DHPSchr19

12791139

-
In-frameENST00000357332ENST00000594424ASNA1chr19

12849472

+DHPSchr19

12791139

-
5CDS-5UTRENST00000357332ENST00000599481ASNA1chr19

12849472

+DHPSchr19

12791139

-

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FusionProtFeatures for ASNA1_DHPS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASNA1

O43681

DHPS

P49366

ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer revertstowards the open dimer state, lowering its affinity for themembrane-bound receptor, and returning it to the cytosol toinitiate a new round of targeting (By similarity). May be involvedin insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112,ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612,ECO:0000269|PubMed:25535373}. Catalyzes the NAD-dependent oxidative cleavage ofspermidine and the subsequent transfer of the butylamine moiety ofspermidine to the epsilon-amino group of a critical lysine residueof the eIF-5A precursor protein to form the intermediatedeoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual aminoacid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASNA1chr19:12849472chr19:12791139ENST00000357332+2745_52103349Nucleotide bindingATP
HgeneASNA1chr19:12849472chr19:12791139ENST00000591090+3845_52103349Nucleotide bindingATP
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09105_10969370Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09131_13369370Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09308_30969370Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09342_34369370Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08105_10969323Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08131_13369323Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08308_30969323Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08342_34369323Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09105_10927328Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09131_13327328Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09308_30927328Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09342_34327328Nucleotide bindingNAD
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09136_13769370RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09314_31669370RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000210060-09323_32969370RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08136_13769323RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08314_31669323RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000351660-08323_32969323RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09136_13727328RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09314_31627328RegionSpermidine binding
TgeneDHPSchr19:12849472chr19:12791139ENST00000594424-09323_32927328RegionSpermidine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASNA1_DHPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASNA1_DHPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASNA1UBL4A, CACNA1A, TK1, TTR, PFDN1, UBE2J1, SEC61B, SEC61A1, VAMP2, STX5, BAG6, EIF6, HSPA8, RARS, RUVBL2, TUBB, VAPB, FAF1, UBC, APLN, STATH, SGTA, HUWE1, ASPH, GPX7, HILPDA, CUL7, GET4, RNF126, DNAJB2, PSMB1, PSMB2, PSMB3, PSMB5, PSMB6, TARBP1, PSMA2, PSMA4, NTRK1, OTUB1, CAMLG, WRB, ZNF579, ASPSCR1, NUDT9, CCND2DHPSNIF3L1, NUDT18, EIF5A2, RPL9, ARF6, SRRM2, MAPK3, ACTR2, ANKMY2, ANP32B, ARIH1, ARPC1B, CTPS2, AAMP, RPA3, SAE1, DPP8, HNRNPF, HSF1, PLIN3, PPP2R5D, SRP9, SURF2, DHPS, EIF5A, PTPRH, RAB27B, REL, ZNF138, VASH1, WDYHV1, BRCA1, TIRAP, SUSD4, BYSL, SPHK1, KCNAB3, CDK17, PTPN7, PTPRR, DUSP19, DUSP28, FAM19A3, SAFB2, ARHGAP15, CFAP46, ZNF414, SFPQ, SPATA24, PROSER2, LRRC6, PTPDC1, EXOSC4, EXOSC2, EXOSC7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASNA1_DHPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASNA1_DHPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource