FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30060

FusionGeneSummary for RAB6A_MICA

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB6A_MICA
Fusion gene ID: 30060
HgeneTgene
Gene symbol

RAB6A

MICA

Gene ID

5870

100507436

Gene nameRAB6A, member RAS oncogene familyMHC class I polypeptide-related sequence A
SynonymsRAB6MIC-A|PERB11.1
Cytomap

11q13.4

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-6ARAB6, member RAS oncogene familyRab GTPaseMHC class I polypeptide-related sequence AHLA class I antigenMHC class I chain-related protein AMHC class I related chain AMHC class I related sequence Astress inducible class I homologtruncated MHC class I polypeptide-related sequence A
Modification date2018052320180523
UniProtAcc

P20340

Q29983

Ensembl transtripts involved in fusion geneENST00000310653, ENST00000336083, 
ENST00000536566, ENST00000541588, 
ENST00000449934, ENST00000417899, 
ENST00000497496, ENST00000427477, 
ENST00000446505, ENST00000547767, 
ENST00000400322, ENST00000493320, 
ENST00000400325, ENST00000547609, 
ENST00000420259, ENST00000468858, 
ENST00000418465, ENST00000432479, 
ENST00000552236, ENST00000438928, 
ENST00000486844, ENST00000415525, 
ENST00000414473, ENST00000546529, 
Fusion gene scores* DoF score10 X 5 X 8=4002 X 2 X 2=8
# samples 102
** MAII scorelog2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: RAB6A [Title/Abstract] AND MICA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB6A

GO:0018125

peptidyl-cysteine methylation

11121396

HgeneRAB6A

GO:0034067

protein localization to Golgi apparatus

12447383|18243103

TgeneMICA

GO:0001913

T cell mediated cytotoxicity

10426993

TgeneMICA

GO:0002418

immune response to tumor cell

10359807

TgeneMICA

GO:0006974

cellular response to DNA damage stimulus

15995699

TgeneMICA

GO:0009408

response to heat

8901601

TgeneMICA

GO:0032815

negative regulation of natural killer cell activation

20068167

TgeneMICA

GO:0042267

natural killer cell mediated cytotoxicity

10426993

TgeneMICA

GO:0042742

defense response to bacterium

11485740|11830641

TgeneMICA

GO:0046629

gamma-delta T cell activation

9497295

TgeneMICA

GO:0051607

defense response to virus

11224526|16750166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A23Z-01ARAB6Achr11

73441810

-MICAchr6

31378320

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310653ENST00000449934RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000417899RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000497496RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000427477RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000446505RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000547767RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000400322RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000493320RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000400325RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000547609RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000420259RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000468858RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000418465RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000432479RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000552236RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000438928RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000486844RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000415525RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000414473RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000310653ENST00000546529RAB6Achr11

73441810

-MICAchr6

31378320

+
Frame-shiftENST00000336083ENST00000449934RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000417899RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000497496RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000427477RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000446505RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000547767RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000400322RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000493320RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000400325RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000547609RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000420259RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000468858RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000418465RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000432479RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000552236RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000438928RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000486844RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000415525RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000414473RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000336083ENST00000546529RAB6Achr11

73441810

-MICAchr6

31378320

+
Frame-shiftENST00000536566ENST00000449934RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000417899RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000497496RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000427477RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000446505RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000547767RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000400322RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000493320RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000400325RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000547609RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000420259RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000468858RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000418465RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000432479RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000552236RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000438928RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000486844RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000415525RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000414473RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000536566ENST00000546529RAB6Achr11

73441810

-MICAchr6

31378320

+
Frame-shiftENST00000541588ENST00000449934RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000417899RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000497496RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000427477RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000446505RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000547767RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000400322RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000493320RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000400325RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000547609RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000420259RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000468858RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000418465RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000432479RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000552236RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000438928RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000486844RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000415525RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000414473RAB6Achr11

73441810

-MICAchr6

31378320

+
5CDS-intronENST00000541588ENST00000546529RAB6Achr11

73441810

-MICAchr6

31378320

+

Top

FusionProtFeatures for RAB6A_MICA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB6A

P20340

MICA

Q29983

Protein transport. Regulator of membrane traffic fromthe Golgi apparatus towards the endoplasmic reticulum (ER). Has alow GTPase activity. Involved in COPI-independent retrogradetransport from the Golgi to the ER (PubMed:25962623).{ECO:0000269|PubMed:25962623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RAB6A_MICA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RAB6A_MICA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAB6APMM1, GOLGA1, BICD1, DCTN1, ERC1, RAB7A, CHM, CHML, GOLGA2, SYTL5, KIF20A, BICD2, RABGAP1, ELAVL1, RPA3, RPA2, RPA1, FKBP2, OCRL, SRPRB, HAX1, DNAAF2, TGFBR2, TREML2, RNF26, TMEM52B, RAB11B, ARF1, ETFA, RAB1A, RAB1B, RAB2A, OFD1, NPHP1, RPGRIP1L, GDI1, TSSC1, ZNF131, RAB6B, TRIM25MICAPOT1, TAZ, GGH, PGLYRP3, VAC14, FLVCR1, TNPO2, SCAMP1, RYK, ADAP2, TNPO3, NCR3LG1, ERLEC1, VAMP3, PGRMC2, TNFRSF10B, TNFSF9, PHF7, AAR2, PTPRK, SCGB1D1, EPHA7, DEFA5, TCTN1, LYPD4, SPINK4, DEFA1, AVP, FAM19A3, INSL5, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RAB6A_MICA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RAB6A_MICA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMICAC0010051Coronary Aneurysm1CTD_human
TgeneMICAC0029172Oral Submucous Fibrosis1CTD_human
TgeneMICAC2239176Liver carcinoma1CTD_human