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Fusion gene ID: 300 |
FusionGeneSummary for ABTB2_NDUFB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABTB2_NDUFB1 | Fusion gene ID: 300 | Hgene | Tgene | Gene symbol | ABTB2 | NDUFB1 | Gene ID | 25841 | 4707 |
| Gene name | ankyrin repeat and BTB domain containing 2 | NADH:ubiquinone oxidoreductase subunit B1 | |
| Synonyms | ABTB2A|BTBD22 | CI-MNLL|CI-SGDH|MNLL | |
| Cytomap | 11p13 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDaNADH-ubiquinone oxidoreductase MNLL subunitcomplex I MNLL subunitcomplex I-MNLL | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q8N961 | O75438 | |
| Ensembl transtripts involved in fusion gene | ENST00000298992, ENST00000435224, ENST00000530814, | ENST00000553514, ENST00000329559, ENST00000605997, ENST00000555441, ENST00000556555, | |
| Fusion gene scores | * DoF score | 6 X 4 X 3=72 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ABTB2 [Title/Abstract] AND NDUFB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0XU-01A | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000298992 | ENST00000553514 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000298992 | ENST00000329559 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| In-frame | ENST00000298992 | ENST00000605997 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000298992 | ENST00000555441 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| 5CDS-intron | ENST00000298992 | ENST00000556555 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| In-frame | ENST00000435224 | ENST00000553514 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000435224 | ENST00000329559 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| In-frame | ENST00000435224 | ENST00000605997 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000435224 | ENST00000555441 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| 5CDS-intron | ENST00000435224 | ENST00000556555 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000553514 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000329559 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000605997 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000555441 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-intron | ENST00000530814 | ENST00000556555 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
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FusionProtFeatures for ABTB2_NDUFB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABTB2 | NDUFB1 |
| May be involved in the initiation of hepatocyte growth.{ECO:0000250}. | Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I) that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000298992 | - | 1 | 17 | 845_914 | 108 | 840 | Domain | BTB |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000435224 | - | 1 | 17 | 845_914 | 294 | 1026 | Domain | BTB |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000298992 | - | 1 | 17 | 521_550 | 108 | 840 | Repeat | Note=ANK 1 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000298992 | - | 1 | 17 | 567_596 | 108 | 840 | Repeat | Note=ANK 2 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000298992 | - | 1 | 17 | 606_635 | 108 | 840 | Repeat | Note=ANK 3 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000298992 | - | 1 | 17 | 649_678 | 108 | 840 | Repeat | Note=ANK 4 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000435224 | - | 1 | 17 | 521_550 | 294 | 1026 | Repeat | Note=ANK 1 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000435224 | - | 1 | 17 | 567_596 | 294 | 1026 | Repeat | Note=ANK 2 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000435224 | - | 1 | 17 | 606_635 | 294 | 1026 | Repeat | Note=ANK 3 |
| Hgene | >ABTB2 | chr11:34378248 | chr14:92582573 | ENST00000435224 | - | 1 | 17 | 649_678 | 294 | 1026 | Repeat | Note=ANK 4 |
| Tgene | NDUFB1 | chr11:34378248 | chr14:92582573 | ENST00000329559 | - | 1 | 3 | 11_27 | 93 | 106 | Transmembrane | Helical |
| Tgene | NDUFB1 | chr11:34378248 | chr14:92582573 | ENST00000553514 | - | 2 | 4 | 11_27 | 46 | 59 | Transmembrane | Helical |
| Tgene | NDUFB1 | chr11:34378248 | chr14:92582573 | ENST00000555441 | - | 1 | 3 | 11_27 | 46 | 59 | Transmembrane | Helical |
| Tgene | NDUFB1 | chr11:34378248 | chr14:92582573 | ENST00000605997 | - | 1 | 3 | 11_27 | 46 | 59 | Transmembrane | Helical |
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FusionGeneSequence for ABTB2_NDUFB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ABTB2_ENST00000298992_chr11_34378248_-_NDUFB1_ENST00000553514_chr14_92582573_-_120aa MSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAE >In-frame_ABTB2_ENST00000298992_chr11_34378248_-_NDUFB1_ENST00000605997_chr14_92582573_-_120aa MSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAE >In-frame_ABTB2_ENST00000435224_chr11_34378248_-_NDUFB1_ENST00000553514_chr14_92582573_-_306aa MAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLPEDPEVADLFSRCPR LPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVK ALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMV >In-frame_ABTB2_ENST00000435224_chr11_34378248_-_NDUFB1_ENST00000605997_chr14_92582573_-_306aa MAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLPEDPEVADLFSRCPR LPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVK ALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ABTB2_ENST00000298992_chr11_34378248_-_NDUFB1_ENST00000553514_chr14_92582573_-_362nt ATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGAC ACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTG ATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAG CTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGT >In-frame_ABTB2_ENST00000298992_chr11_34378248_-_NDUFB1_ENST00000605997_chr14_92582573_-_362nt ATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGAC ACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTG ATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAG CTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGT >In-frame_ABTB2_ENST00000435224_chr11_34378248_-_NDUFB1_ENST00000553514_chr14_92582573_-_920nt ATGGCCGGGACGTACAGCTCGACTCTGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTC AGCCTCTCGTCCTCCAAGTCCAACTCGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCC ATGAACAGCCGCCACAACAGCTGGGACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGG CTCCCCGAGCTGGAGGAGTTCCCCTGGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTC TCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCAC GCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAG GCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTT TTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAG GAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTC ATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTG >In-frame_ABTB2_ENST00000435224_chr11_34378248_-_NDUFB1_ENST00000605997_chr14_92582573_-_920nt ATGGCCGGGACGTACAGCTCGACTCTGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTC AGCCTCTCGTCCTCCAAGTCCAACTCGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCC ATGAACAGCCGCCACAACAGCTGGGACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGG CTCCCCGAGCTGGAGGAGTTCCCCTGGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTC TCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCAC GCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAG GCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTT TTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAG GAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTC ATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ABTB2_ENST00000298992_chr11_34378248_-_NDUFB1_ENST00000553514_chr14_92582573_-_663nt AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG GCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACTGGCTAGATTATCGAATGTTCACATTTTAAAGTT >In-frame_ABTB2_ENST00000298992_chr11_34378248_-_NDUFB1_ENST00000605997_chr14_92582573_-_660nt AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG GCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACTGGCTAGATTATCGAATGTTCACATTTTAAAGTT >In-frame_ABTB2_ENST00000435224_chr11_34378248_-_NDUFB1_ENST00000553514_chr14_92582573_-_1416nt AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACT >In-frame_ABTB2_ENST00000435224_chr11_34378248_-_NDUFB1_ENST00000605997_chr14_92582573_-_1413nt AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACT |
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FusionGenePPI for ABTB2_NDUFB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ABTB2 | EEF1A1, CUL3, RBX1, DNTT, COPS5, XPO1, DUSP26, HS1BP3, TCTEX1D2, TRIM25 | NDUFB1 | EWSR1, NDUFA5, APP, NDUFS3, ECSIT, NDUFA8, NDUFA9, GOLT1B, NDUFA4, COQ9, C15orf48, OCIAD1, NDUFS6, SPPL2B, C3AR1, NDUFB11, NDUFB5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ABTB2_NDUFB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ABTB2_NDUFB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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