|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 29999 |
FusionGeneSummary for RAB3GAP1_CHMP1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB3GAP1_CHMP1A | Fusion gene ID: 29999 | Hgene | Tgene | Gene symbol | RAB3GAP1 | CHMP1A | Gene ID | 22930 | 5119 |
| Gene name | RAB3 GTPase activating protein catalytic subunit 1 | charged multivesicular body protein 1A | |
| Synonyms | P130|RAB3GAP|RAB3GAP130|WARBM1 | CHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A | |
| Cytomap | 2q21.3 | 16q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rab3 GTPase-activating protein catalytic subunitRAB3 GTPase activating protein subunit 1 (catalytic)RAB3 GTPase-activating protein 130 kDa subunitrab3-GAP p130 | charged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15042 | Q9HD42 | |
| Ensembl transtripts involved in fusion gene | ENST00000264158, ENST00000539493, ENST00000442034, ENST00000487003, ENST00000425393, | ENST00000397901, ENST00000253475, ENST00000535997, ENST00000550102, ENST00000547614, | |
| Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 15 X 8 X 9=1080 |
| # samples | 11 | 20 | |
| ** MAII score | log2(11/384*10)=-1.8036027871965 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1080*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAB3GAP1 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAB3GAP1 | GO:0043087 | regulation of GTPase activity | 10859313 |
| Tgene | CHMP1A | GO:0007076 | mitotic chromosome condensation | 11559747 |
| Tgene | CHMP1A | GO:0016192 | vesicle-mediated transport | 11559748 |
| Tgene | CHMP1A | GO:0016458 | gene silencing | 11559747 |
| Tgene | CHMP1A | GO:0045892 | negative regulation of transcription, DNA-templated | 11559747 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CF593854 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264158 | ENST00000397901 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| Frame-shift | ENST00000264158 | ENST00000253475 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| In-frame | ENST00000264158 | ENST00000535997 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| In-frame | ENST00000264158 | ENST00000550102 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5CDS-5UTR | ENST00000264158 | ENST00000547614 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5UTR-3CDS | ENST00000539493 | ENST00000397901 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5UTR-3CDS | ENST00000539493 | ENST00000253475 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5UTR-3CDS | ENST00000539493 | ENST00000535997 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5UTR-3CDS | ENST00000539493 | ENST00000550102 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5UTR-5UTR | ENST00000539493 | ENST00000547614 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| In-frame | ENST00000442034 | ENST00000397901 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| Frame-shift | ENST00000442034 | ENST00000253475 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| In-frame | ENST00000442034 | ENST00000535997 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| In-frame | ENST00000442034 | ENST00000550102 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5CDS-5UTR | ENST00000442034 | ENST00000547614 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| intron-3CDS | ENST00000487003 | ENST00000397901 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| intron-3CDS | ENST00000487003 | ENST00000253475 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| intron-3CDS | ENST00000487003 | ENST00000535997 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| intron-3CDS | ENST00000487003 | ENST00000550102 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| intron-5UTR | ENST00000487003 | ENST00000547614 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| Frame-shift | ENST00000425393 | ENST00000397901 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| Frame-shift | ENST00000425393 | ENST00000253475 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| Frame-shift | ENST00000425393 | ENST00000535997 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| Frame-shift | ENST00000425393 | ENST00000550102 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
| 5CDS-5UTR | ENST00000425393 | ENST00000547614 | RAB3GAP1 | chr2 | 135815658 | + | CHMP1A | chr16 | 89713741 | - |
Top |
FusionProtFeatures for RAB3GAP1_CHMP1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB3GAP1 | CHMP1A |
| Probable catalytic subunit of a GTPase activatingprotein that has specificity for Rab3 subfamily (RAB3A, RAB3B,RAB3C and RAB3D). Rab3 proteins are involved in regulatedexocytosis of neurotransmitters and hormones. Specificallyconverts active Rab3-GTP to the inactive form Rab3-GDP. Requiredfor normal eye and brain development. May participate inneurodevelopmental processes such as proliferation, migration anddifferentiation before synapse formation, and non-synapticvesicular release of neurotransmitters.{ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:9030515}. | Probable peripherally associated component of theendosomal sorting required for transport complex III (ESCRT-III)which is involved in multivesicular bodies (MVBs) formation andsorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invaginationand scission from the limiting membrane of the endosome and mostlyare delivered to lysosomes enabling degradation of membraneproteins, such as stimulated growth factor receptors, lysosomalenzymes and lipids. The MVB pathway appears to require thesequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membranebefore the ILV is released. The ESCRT machinery also functions intopologically equivalent membrane fission events, such as theterminal stages of cytokinesis and the budding of envelopedviruses (HIV-1 and other lentiviruses). ESCRT-III proteins arebelieved to mediate the necessary vesicle extrusion and/ormembrane fission activities, possibly in conjunction with the AAAATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4Aand/or VPS4B to the midbody of dividing cells. May also beinvolved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. Mayplay a role in stable cell cycle progression and in PcG genesilencing. {ECO:0000269|PubMed:11559747,ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479,ECO:0000269|PubMed:23045692}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CHMP1A | chr2:135815658 | chr16:89713741 | ENST00000397901 | - | 3 | 7 | 102_124 | 84 | 197 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CHMP1A | chr2:135815658 | chr16:89713741 | ENST00000397901 | - | 3 | 7 | 185_195 | 84 | 197 | Motif | Note=MIT-interacting motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CHMP1A | chr2:135815658 | chr16:89713741 | ENST00000397901 | - | 3 | 7 | 5_47 | 84 | 197 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
FusionGeneSequence for RAB3GAP1_CHMP1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000397901_chr16_89713741_-_163aa MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDV >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000535997_chr16_89713741_-_163aa MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDV >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000550102_chr16_89713741_-_163aa MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDV >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000397901_chr16_89713741_-_163aa MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDV >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000535997_chr16_89713741_-_163aa MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDV >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000550102_chr16_89713741_-_163aa MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000397901_chr16_89713741_-_489nt ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTT GAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAA GCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTC CATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCC GAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAG >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000535997_chr16_89713741_-_489nt ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTT GAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAA GCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTC CATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCC GAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAG >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000550102_chr16_89713741_-_489nt ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTT GAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAA GCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTC CATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCC GAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAG >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000397901_chr16_89713741_-_489nt ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTT GAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAA GCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTC CATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCC GAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAG >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000535997_chr16_89713741_-_489nt ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTT GAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAA GCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTC CATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCC GAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAG >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000550102_chr16_89713741_-_489nt ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTT GAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAA GCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTC CATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCC GAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000397901_chr16_89713741_-_2167nt CTTCTTCCCGGCAGCCTTAGCGCCAGGCCCGGCGCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGA CTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAA GCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTC AGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGAC CACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGA GGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCC CGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGG CTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCT GTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGAC TTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGC CAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGT CTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGG TGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGG GACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGC CACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTT GGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACT GGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTG GGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTG AGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTG CCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCC CACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTG GTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACC CTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCT GCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCCCATTCACCTTTCTCCTAGAATGCTGTTGTAAATAAACAAATGGATCCCTGG >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000535997_chr16_89713741_-_2135nt CTTCTTCCCGGCAGCCTTAGCGCCAGGCCCGGCGCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGA CTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAA GCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTC AGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGAC CACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGA GGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCC CGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGG CTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCT GTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGAC TTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGC CAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGT CTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGG TGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGG GACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGC CACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTT GGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACT GGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTG GGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTG AGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTG CCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCC CACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTG GTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACC CTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCT >In-frame_RAB3GAP1_ENST00000264158_chr2_135815658_+_CHMP1A_ENST00000550102_chr16_89713741_-_709nt CTTCTTCCCGGCAGCCTTAGCGCCAGGCCCGGCGCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGA CTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAA GCCACTCGAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTC AGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGAC CACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGA GGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCC CGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGG >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000397901_chr16_89713741_-_2134nt GCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTAT TTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCA GGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAA CCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCAT GCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCG CAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTG CTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCT GCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGG GGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCT GGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCT CAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCA ACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCC CCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTG TGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGG GAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTT GGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTC CCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTG CCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTC CATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGG CAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGG TGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGA GGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGT GGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGA >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000535997_chr16_89713741_-_2102nt GCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTAT TTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCA GGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAA CCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCAT GCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCG CAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTG CTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCT GCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGG GGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCT GGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCT CAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCA ACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCC CCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTG TGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGG GAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTT GGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTC CCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTG CCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTC CATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGG CAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGG TGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGA GGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGT GGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGA >In-frame_RAB3GAP1_ENST00000442034_chr2_135815658_+_CHMP1A_ENST00000550102_chr16_89713741_-_676nt GCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTAT TTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTGACCAAGAATATGGCCCA GGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAA CCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCAT GCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCG CAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTG CTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCT |
Top |
FusionGenePPI for RAB3GAP1_CHMP1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAB3GAP1 | RPH3AL, WDR7, DMXL2, MAP1LC3A, FEZ1, FEZ2, RAB22A, RAB39A, RAB39B, LMAN1, PAXIP1, VCP, GABPA, GNE, NCOA7, RAB3GAP2, TSEN34, VAPB, VAPA, BCAT1, BTN2A1, SIRT2, DCAF15, NTRK1, NPHP1, BRAF, ALOX5, C6orf141, DOCK5, RCCD1, PSMC4, TRIM25, TES | CHMP1A | KIAA1715, VPS4A, STAMBP, USP8, NR1I2, VPS4B, CHMP1A, CHMP1B, UBE2I, ATP6V1B1, FBXL18, OAS3, MOV10, NXF1, ZDHHC17, MEOX1, IST1, VSX2, LHX4, ZNF524, CLTC, RAB5C, RAB7A, TFG, GOLT1B, CHMP4B, MCM2, NF2, CHMP5, SIX2, BROX, HMGN2, GPX7, MECP2, HEY2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RAB3GAP1_CHMP1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RAB3GAP1_CHMP1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|