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Fusion gene ID: 29982 |
FusionGeneSummary for RAB35_SLC25A36 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RAB35_SLC25A36 | Fusion gene ID: 29982 | Hgene | Tgene | Gene symbol | RAB35 | SLC25A36 | Gene ID | 11021 | 55186 |
Gene name | RAB35, member RAS oncogene family | solute carrier family 25 member 36 | |
Synonyms | H-ray|RAB1C|RAY | PNC2 | |
Cytomap | 12q24.23 | 3q23 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-35GTP-binding protein RAYras-related protein rab-1c (GTP-binding protein ray) | solute carrier family 25 member 36solute carrier family 25 (pyrimidine nucleotide carrier ), member 36 | |
Modification date | 20180526 | 20180523 | |
UniProtAcc | Q15286 | Q96CQ1 | |
Ensembl transtripts involved in fusion gene | ENST00000229340, ENST00000432953, ENST00000534951, ENST00000543364, | ENST00000446041, ENST00000393015, ENST00000507429, ENST00000324194, ENST00000453248, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 4 X 2=24 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RAB35 [Title/Abstract] AND SLC25A36 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SLC25A36 | GO:0000002 | mitochondrial genome maintenance | 25320081 |
Tgene | SLC25A36 | GO:0006864 | pyrimidine nucleotide transport | 25320081 |
Tgene | SLC25A36 | GO:0007005 | mitochondrion organization | 25320081 |
Tgene | SLC25A36 | GO:0051881 | regulation of mitochondrial membrane potential | 25320081 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE819067 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000229340 | ENST00000446041 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000229340 | ENST00000393015 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000229340 | ENST00000507429 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000229340 | ENST00000324194 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000229340 | ENST00000453248 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000432953 | ENST00000446041 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000432953 | ENST00000393015 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000432953 | ENST00000507429 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000432953 | ENST00000324194 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000432953 | ENST00000453248 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000534951 | ENST00000446041 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000534951 | ENST00000393015 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000534951 | ENST00000507429 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000534951 | ENST00000324194 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000534951 | ENST00000453248 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000543364 | ENST00000446041 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000543364 | ENST00000393015 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000543364 | ENST00000507429 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000543364 | ENST00000324194 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
intron-intron | ENST00000543364 | ENST00000453248 | RAB35 | chr12 | 120534745 | - | SLC25A36 | chr3 | 140678382 | - |
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FusionProtFeatures for RAB35_SLC25A36 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
RAB35 | SLC25A36 |
The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. That Rab is involved in the process ofendocytosis and is an essential rate-limiting regulator of thefast recycling pathway back to the plasma membrane. Duringcytokinesis, required for the postfurrowing terminal steps, namelyfor intercellular bridge stability and abscission, possibly bycontrolling phosphatidylinositol 4,5-bis phosphate (PIP2) andSEPT2 localization at the intercellular bridge. May indirectlyregulate neurite outgrowth. Together with TBC1D13 may be involvedin regulation of insulin-induced glucose transporter SLC2A4/GLUT4translocation to the plasma membrane in adipocytes.{ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109,ECO:0000269|PubMed:21951725}. | Mitochondrial transporter that imports/exportspyrimidine nucleotides into and from mitochondria. Transportspreferentially cytosine and uracil (deoxy)nucleoside mono-, di-,and triphosphates by uniport and antiport mechanism. Alsotransports guanine but not adenine (deoxy)nucleotides. Isinhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride,Mersalyl acid, p-hydroxymercuribenzoate). Participates inmitochondrial genome maintenance, regulation of mitochondrialmembrane potential and mitochondrial respiration.{ECO:0000269|PubMed:25320081}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB35_SLC25A36 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB35_SLC25A36 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB35_SLC25A36 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB35_SLC25A36 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |