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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29982

FusionGeneSummary for RAB35_SLC25A36

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB35_SLC25A36
Fusion gene ID: 29982
HgeneTgene
Gene symbol

RAB35

SLC25A36

Gene ID

11021

55186

Gene nameRAB35, member RAS oncogene familysolute carrier family 25 member 36
SynonymsH-ray|RAB1C|RAYPNC2
Cytomap

12q24.23

3q23

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-35GTP-binding protein RAYras-related protein rab-1c (GTP-binding protein ray)solute carrier family 25 member 36solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
Modification date2018052620180523
UniProtAcc

Q15286

Q96CQ1

Ensembl transtripts involved in fusion geneENST00000229340, ENST00000432953, 
ENST00000534951, ENST00000543364, 
ENST00000446041, ENST00000393015, 
ENST00000507429, ENST00000324194, 
ENST00000453248, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 4 X 2=24
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RAB35 [Title/Abstract] AND SLC25A36 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC25A36

GO:0000002

mitochondrial genome maintenance

25320081

TgeneSLC25A36

GO:0006864

pyrimidine nucleotide transport

25320081

TgeneSLC25A36

GO:0007005

mitochondrion organization

25320081

TgeneSLC25A36

GO:0051881

regulation of mitochondrial membrane potential

25320081


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE819067RAB35chr12

120534745

-SLC25A36chr3

140678382

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000229340ENST00000446041RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000229340ENST00000393015RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000229340ENST00000507429RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000229340ENST00000324194RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000229340ENST00000453248RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000432953ENST00000446041RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000432953ENST00000393015RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000432953ENST00000507429RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000432953ENST00000324194RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000432953ENST00000453248RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000534951ENST00000446041RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000534951ENST00000393015RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000534951ENST00000507429RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000534951ENST00000324194RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000534951ENST00000453248RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000543364ENST00000446041RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000543364ENST00000393015RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000543364ENST00000507429RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000543364ENST00000324194RAB35chr12

120534745

-SLC25A36chr3

140678382

-
intron-intronENST00000543364ENST00000453248RAB35chr12

120534745

-SLC25A36chr3

140678382

-

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FusionProtFeatures for RAB35_SLC25A36


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB35

Q15286

SLC25A36

Q96CQ1

The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. That Rab is involved in the process ofendocytosis and is an essential rate-limiting regulator of thefast recycling pathway back to the plasma membrane. Duringcytokinesis, required for the postfurrowing terminal steps, namelyfor intercellular bridge stability and abscission, possibly bycontrolling phosphatidylinositol 4,5-bis phosphate (PIP2) andSEPT2 localization at the intercellular bridge. May indirectlyregulate neurite outgrowth. Together with TBC1D13 may be involvedin regulation of insulin-induced glucose transporter SLC2A4/GLUT4translocation to the plasma membrane in adipocytes.{ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109,ECO:0000269|PubMed:21951725}. Mitochondrial transporter that imports/exportspyrimidine nucleotides into and from mitochondria. Transportspreferentially cytosine and uracil (deoxy)nucleoside mono-, di-,and triphosphates by uniport and antiport mechanism. Alsotransports guanine but not adenine (deoxy)nucleotides. Isinhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride,Mersalyl acid, p-hydroxymercuribenzoate). Participates inmitochondrial genome maintenance, regulation of mitochondrialmembrane potential and mitochondrial respiration.{ECO:0000269|PubMed:25320081}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB35_SLC25A36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB35_SLC25A36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB35_SLC25A36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB35_SLC25A36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource