|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 29981 |
FusionGeneSummary for RAB35_GCN1L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB35_GCN1L1 | Fusion gene ID: 29981 | Hgene | Tgene | Gene symbol | RAB35 | GCN1L1 | Gene ID | 11021 | 10985 |
| Gene name | RAB35, member RAS oncogene family | GCN1, eIF2 alpha kinase activator homolog | |
| Synonyms | H-ray|RAB1C|RAY | GCN1L|GCN1L1|PRIC295 | |
| Cytomap | 12q24.23 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related protein Rab-35GTP-binding protein RAYras-related protein rab-1c (GTP-binding protein ray) | eIF-2-alpha kinase activator GCN1GCN1 (general control of amino-acid synthesis 1, yeast)-like 1GCN1 eIF-2-alpha kinase activator homologGCN1 general control of amino-acid synthesis 1-like 1GCN1-like protein 1general control of amino-acid synthesis 1- | |
| Modification date | 20180526 | 20180522 | |
| UniProtAcc | Q15286 | ||
| Ensembl transtripts involved in fusion gene | ENST00000229340, ENST00000432953, ENST00000534951, ENST00000543364, | ENST00000300648, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RAB35 [Title/Abstract] AND GCN1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMT-01A | RAB35 | chr12 | 120546221 | - | GCN1L1 | chr12 | 120587847 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000229340 | ENST00000300648 | RAB35 | chr12 | 120546221 | - | GCN1L1 | chr12 | 120587847 | - |
| intron-3CDS | ENST00000432953 | ENST00000300648 | RAB35 | chr12 | 120546221 | - | GCN1L1 | chr12 | 120587847 | - |
| In-frame | ENST00000534951 | ENST00000300648 | RAB35 | chr12 | 120546221 | - | GCN1L1 | chr12 | 120587847 | - |
| intron-3CDS | ENST00000543364 | ENST00000300648 | RAB35 | chr12 | 120546221 | - | GCN1L1 | chr12 | 120587847 | - |
Top |
FusionProtFeatures for RAB35_GCN1L1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB35 | GCN1L1 |
| The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. That Rab is involved in the process ofendocytosis and is an essential rate-limiting regulator of thefast recycling pathway back to the plasma membrane. Duringcytokinesis, required for the postfurrowing terminal steps, namelyfor intercellular bridge stability and abscission, possibly bycontrolling phosphatidylinositol 4,5-bis phosphate (PIP2) andSEPT2 localization at the intercellular bridge. May indirectlyregulate neurite outgrowth. Together with TBC1D13 may be involvedin regulation of insulin-induced glucose transporter SLC2A4/GLUT4translocation to the plasma membrane in adipocytes.{ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109,ECO:0000269|PubMed:21951725}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAB35 | chr12:120546221 | chr12:120587847 | ENST00000229340 | - | 2 | 6 | 15_22 | 34 | 202 | Nucleotide binding | GTP |
| Hgene | RAB35 | chr12:120546221 | chr12:120587847 | ENST00000534951 | - | 2 | 5 | 15_22 | 34 | 153 | Nucleotide binding | GTP |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1455_1492 | 1436 | 2672 | Repeat | HEAT 22 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1493_1530 | 1436 | 2672 | Repeat | HEAT 23 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1534_1571 | 1436 | 2672 | Repeat | HEAT 24 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1573_1609 | 1436 | 2672 | Repeat | HEAT 25 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1611_1648 | 1436 | 2672 | Repeat | HEAT 26 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1653_1690 | 1436 | 2672 | Repeat | HEAT 27 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1692_1729 | 1436 | 2672 | Repeat | HEAT 28 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1731_1769 | 1436 | 2672 | Repeat | HEAT 29 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1773_1810 | 1436 | 2672 | Repeat | HEAT 30 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1812_1848 | 1436 | 2672 | Repeat | HEAT 31 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1921_1958 | 1436 | 2672 | Repeat | HEAT 32 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1959_1996 | 1436 | 2672 | Repeat | HEAT 33 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2001_2038 | 1436 | 2672 | Repeat | HEAT 34 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2039_2076 | 1436 | 2672 | Repeat | HEAT 35 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2078_2106 | 1436 | 2672 | Repeat | HEAT 36 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2107_2146 | 1436 | 2672 | Repeat | HEAT 37 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2147_2184 | 1436 | 2672 | Repeat | HEAT 38 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2188_2225 | 1436 | 2672 | Repeat | HEAT 39 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2259_2296 | 1436 | 2672 | Repeat | HEAT 40 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2301_2338 | 1436 | 2672 | Repeat | HEAT 41 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2339_2380 | 1436 | 2672 | Repeat | HEAT 42 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2382_2417 | 1436 | 2672 | Repeat | HEAT 43 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2422_2459 | 1436 | 2672 | Repeat | HEAT 44 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2546_2583 | 1436 | 2672 | Repeat | HEAT 45 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2588_2625 | 1436 | 2672 | Repeat | HEAT 46 |
| Tgene | >GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 2627_2661 | 1436 | 2672 | Repeat | HEAT 47%3B degenerate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RAB35 | chr12:120546221 | chr12:120587847 | ENST00000229340 | - | 2 | 6 | 37_45 | 34 | 202 | Motif | Effector region |
| Hgene | >RAB35 | chr12:120546221 | chr12:120587847 | ENST00000534951 | - | 2 | 5 | 37_45 | 34 | 153 | Motif | Effector region |
| Hgene | >RAB35 | chr12:120546221 | chr12:120587847 | ENST00000229340 | - | 2 | 6 | 120_123 | 34 | 202 | Nucleotide binding | GTP |
| Hgene | >RAB35 | chr12:120546221 | chr12:120587847 | ENST00000229340 | - | 2 | 6 | 63_67 | 34 | 202 | Nucleotide binding | GTP |
| Hgene | >RAB35 | chr12:120546221 | chr12:120587847 | ENST00000534951 | - | 2 | 5 | 120_123 | 34 | 153 | Nucleotide binding | GTP |
| Hgene | >RAB35 | chr12:120546221 | chr12:120587847 | ENST00000534951 | - | 2 | 5 | 63_67 | 34 | 153 | Nucleotide binding | GTP |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 804_863 | 1436 | 2672 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1035_1072 | 1436 | 2672 | Repeat | HEAT 13 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1078_1115 | 1436 | 2672 | Repeat | HEAT 14 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1155_1192 | 1436 | 2672 | Repeat | HEAT 15 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1210_1250 | 1436 | 2672 | Repeat | HEAT 16 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1251_1289 | 1436 | 2672 | Repeat | HEAT 17 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1290_1332 | 1436 | 2672 | Repeat | HEAT 18 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1335_1372 | 1436 | 2672 | Repeat | HEAT 19 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1374_1410 | 1436 | 2672 | Repeat | HEAT 20 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 140_178 | 1436 | 2672 | Repeat | HEAT 1 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 1413_1451 | 1436 | 2672 | Repeat | HEAT 21 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 257_293 | 1436 | 2672 | Repeat | HEAT 2 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 294_331 | 1436 | 2672 | Repeat | HEAT 3 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 385_423 | 1436 | 2672 | Repeat | HEAT 4 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 425_459 | 1436 | 2672 | Repeat | HEAT 5 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 460_503 | 1436 | 2672 | Repeat | HEAT 6 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 560_597 | 1436 | 2672 | Repeat | HEAT 7 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 599_636 | 1436 | 2672 | Repeat | HEAT 8 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 697_732 | 1436 | 2672 | Repeat | HEAT 9 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 733_770 | 1436 | 2672 | Repeat | HEAT 10 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 879_925 | 1436 | 2672 | Repeat | HEAT 11 |
| Tgene | GCN1L1 | chr12:120546221 | chr12:120587847 | ENST00000300648 | - | 33 | 58 | 979_1016 | 1436 | 2672 | Repeat | HEAT 12 |
Top |
FusionGeneSequence for RAB35_GCN1L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RAB35_GCN1L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAB35 | CBR3, TBPL1, ALK, ATG16L1, ATP6V1B1, APP, FN1, IQCB1, UBL4A, AMOT, LATS1, RPA3, RPA2, RPA1, CCDC8, UBAC2, ABCE1, CEP97, CNTROB, SPICE1, CNTRL, NPHP1, DCTN1, GDI1, MAPRE1, COQ9, C15orf48, SBF1, CALCOCO2 | GCN1L1 | PTP4A3, MAST2, C20orf24, TNFRSF14, MAGED1, TSC22D1, NEK6, CASP4, BRF2, MAGEA6, MYC, CDC5L, USP19, GTF2A1, ERCC3, CAMKK2, CLN3, PRKAB2, WIPI2, SREBF1, HDAC5, SIRT7, CDK2, SRSF1, HNRNPA3, SNRNP70, SRSF3, TRA2B, PGRMC1, ACAT1, NDUFA5, PDCD6, SAFB, INF2, HNRNPL, SDHA, HSPA1A, ALB, FN1, VCAM1, ITGA4, SOX2, HDAC11, EGFR, YWHAQ, FBXO6, EIF2S2, EPB41L1, MLF2, PSMB8, ASB5, LGR4, PHKG2, ILK, STAU1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, UBAC2, FAF2, BSG, CD274, C4orf3, SCN2B, COPA, DNMT1, EIF2D, ANXA5, COPG1, HARS, SNW1, HELLS, NTRK1, NCBP1, TUBG1, XRCC3, TUBA1C, ARMC6, CRY2, MCM2, ESR1, POU5F1, RC3H1, AIRE, ZNF746, CDH1, PPM1A, TPTE, IL13RA2, NPY2R, MAS1, SCN3B, OPRM1, CHRM4, STOM, UBE2A, BRCA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RAB35_GCN1L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RAB35_GCN1L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|