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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29973

FusionGeneSummary for RAB31_ZEB1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB31_ZEB1
Fusion gene ID: 29973
HgeneTgene
Gene symbol

RAB31

ZEB1

Gene ID

11031

6935

Gene nameRAB31, member RAS oncogene familyzinc finger E-box binding homeobox 1
SynonymsRab22BAREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A
Cytomap

18p11.22

10p11.22

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-31ras-related protein Rab-22Bzinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding prote
Modification date2018052320180527
UniProtAcc

Q13636

P37275

Ensembl transtripts involved in fusion geneENST00000578921, ENST00000577284, 
ENST00000320985, ENST00000361642, 
ENST00000559858, ENST00000560721, 
ENST00000542815, ENST00000446923, 
Fusion gene scores* DoF score4 X 5 X 1=206 X 6 X 2=72
# samples 56
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB31 [Title/Abstract] AND ZEB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZEB1

GO:0000122

negative regulation of transcription by RNA polymerase II

23765923|23814079

TgeneZEB1

GO:0045892

negative regulation of transcription, DNA-templated

20418909


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U19969RAB31chr18

9722157

+ZEB1chr10

31608180

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000578921ENST00000320985RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3CDSENST00000578921ENST00000361642RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3UTRENST00000578921ENST00000559858RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3UTRENST00000578921ENST00000560721RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3UTRENST00000578921ENST00000542815RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-intronENST00000578921ENST00000446923RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3CDSENST00000577284ENST00000320985RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3CDSENST00000577284ENST00000361642RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3UTRENST00000577284ENST00000559858RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3UTRENST00000577284ENST00000560721RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-3UTRENST00000577284ENST00000542815RAB31chr18

9722157

+ZEB1chr10

31608180

+
intron-intronENST00000577284ENST00000446923RAB31chr18

9722157

+ZEB1chr10

31608180

+

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FusionProtFeatures for RAB31_ZEB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB31

Q13636

ZEB1

P37275

The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. Required for the integrity and for normalfunction of the Golgi apparatus and the trans-Golgi network. Playsa role in insulin-stimulated translocation of GLUT4 to the cellmembrane. Plays a role in M6PR transport from the trans-Golginetwork to endosomes. Plays a role in the internalization of EGFRfrom the cell membrane into endosomes. Plays a role in thematuration of phagosomes that engulf pathogens, such as S.aureusand M.tuberculosis. {ECO:0000269|PubMed:17189207,ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050,ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB31_ZEB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB31_ZEB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB31_ZEB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB31_ZEB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAB31C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneZEB1C2750448CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 63CTD_human;UNIPROT
TgeneZEB1C1458155Mammary Neoplasms2CTD_human
TgeneZEB1C0007621Neoplastic Cell Transformation1CTD_human
TgeneZEB1C0014170Endometrial Neoplasms1CTD_human
TgeneZEB1C0027626Neoplasm Invasiveness1CTD_human
TgeneZEB1C0029172Oral Submucous Fibrosis1CTD_human
TgeneZEB1C0036920Sezary Syndrome1CTD_human
TgeneZEB1C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneZEB1C0151744Myocardial Ischemia1CTD_human
TgeneZEB1C0919267ovarian neoplasm1CTD_human