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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29919

FusionGeneSummary for RAB1A_LUC7L3

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB1A_LUC7L3
Fusion gene ID: 29919
HgeneTgene
Gene symbol

RAB1A

LUC7L3

Gene ID

5861

51747

Gene nameRAB1A, member RAS oncogene familyLUC7 like 3 pre-mRNA splicing factor
SynonymsRAB1|YPT1CRA|CREAP-1|CROP|LUC7A|OA48-18|hLuc7A
Cytomap

2p14

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-1AGTP binding protein Rab1aRAB1, member RAS oncogene familyRab GTPase YPT1 homologYPT1-related proteinluc7-like protein 3CRE-associated protein 1LUC7-like 3cAMP regulatory element-associated protein 1cisplatin resistance-associated-overexpressed proteinokadaic acid-inducible phosphoprotein OA48-18
Modification date2018052320180523
UniProtAcc

P62820

O95232

Ensembl transtripts involved in fusion geneENST00000494188, ENST00000409892, 
ENST00000409784, ENST00000398529, 
ENST00000409751, ENST00000260638, 
ENST00000356214, 
ENST00000505658, 
ENST00000393227, ENST00000311571, 
ENST00000240304, ENST00000544170, 
ENST00000503798, 
Fusion gene scores* DoF score7 X 6 X 3=1265 X 6 X 2=60
# samples 86
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: RAB1A [Title/Abstract] AND LUC7L3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE276057RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
ChiTaRS3.1BC000604RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000494188ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000494188ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000494188ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000494188ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000494188ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000494188ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409892ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409892ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409892ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409892ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409892ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000409892ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409784ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409784ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409784ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409784ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409784ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000409784ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000398529ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000398529ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000398529ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000398529ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000398529ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000398529ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409751ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409751ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409751ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409751ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000409751ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000409751ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000260638ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000260638ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000260638ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000260638ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000260638ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000260638ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000356214ENST00000505658RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000356214ENST00000393227RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000356214ENST00000311571RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000356214ENST00000240304RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-5UTRENST00000356214ENST00000544170RAB1Achr2

65357209

+LUC7L3chr17

48797049

+
intron-intronENST00000356214ENST00000503798RAB1Achr2

65357209

+LUC7L3chr17

48797049

+

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FusionProtFeatures for RAB1A_LUC7L3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB1A

P62820

LUC7L3

O95232

The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. RAB1A regulates vesicular protein transportfrom the endoplasmic reticulum (ER) to the Golgi compartment andon to the cell surface, and plays a role in IL-8 and growthhormone secretion. Regulates the level of CASR present at the cellmembrane. Plays a role in cell adhesion and cell migration, viaits role in protein trafficking. Plays a role in autophagosomeassembly and cellular defense reactions against pathogenicbacteria. Plays a role in microtubule-dependent protein transportby early endosomes and in anterograde melanosome transport.{ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236,ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626}. Binds cAMP regulatory element DNA sequence. May play arole in RNA splicing. {ECO:0000269|PubMed:16462885}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB1A_LUC7L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB1A_LUC7L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB1A_LUC7L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB1A_LUC7L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource