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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29917

FusionGeneSummary for RAB1A_C7orf50

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB1A_C7orf50
Fusion gene ID: 29917
HgeneTgene
Gene symbol

RAB1A

C7orf50

Gene ID

5861

84310

Gene nameRAB1A, member RAS oncogene familychromosome 7 open reading frame 50
SynonymsRAB1|YPT1YCR016W
Cytomap

2p14

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-1AGTP binding protein Rab1aRAB1, member RAS oncogene familyRab GTPase YPT1 homologYPT1-related proteinuncharacterized protein C7orf50
Modification date2018052320180519
UniProtAcc

P62820

Q9BRJ6

Ensembl transtripts involved in fusion geneENST00000494188, ENST00000409892, 
ENST00000409784, ENST00000398529, 
ENST00000409751, ENST00000260638, 
ENST00000356214, 
ENST00000357429, 
ENST00000397100, ENST00000397098, 
ENST00000488073, 
Fusion gene scores* DoF score7 X 6 X 3=1263 X 2 X 2=12
# samples 83
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RAB1A [Title/Abstract] AND C7orf50 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8289-01ARAB1Achr2

65357027

-C7orf50chr7

1040187

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000494188ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5UTR-3CDSENST00000494188ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5UTR-3CDSENST00000494188ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5UTR-5UTRENST00000494188ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409892ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409892ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409892ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5CDS-5UTRENST00000409892ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409784ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409784ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409784ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5CDS-5UTRENST00000409784ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000398529ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000398529ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000398529ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5CDS-5UTRENST00000398529ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409751ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409751ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000409751ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5CDS-5UTRENST00000409751ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-
intron-3CDSENST00000260638ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
intron-3CDSENST00000260638ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
intron-3CDSENST00000260638ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
intron-5UTRENST00000260638ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000356214ENST00000357429RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000356214ENST00000397100RAB1Achr2

65357027

-C7orf50chr7

1040187

-
Frame-shitENST00000356214ENST00000397098RAB1Achr2

65357027

-C7orf50chr7

1040187

-
5CDS-5UTRENST00000356214ENST00000488073RAB1Achr2

65357027

-C7orf50chr7

1040187

-

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FusionProtFeatures for RAB1A_C7orf50


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB1A

P62820

C7orf50

Q9BRJ6

The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. RAB1A regulates vesicular protein transportfrom the endoplasmic reticulum (ER) to the Golgi compartment andon to the cell surface, and plays a role in IL-8 and growthhormone secretion. Regulates the level of CASR present at the cellmembrane. Plays a role in cell adhesion and cell migration, viaits role in protein trafficking. Plays a role in autophagosomeassembly and cellular defense reactions against pathogenicbacteria. Plays a role in microtubule-dependent protein transportby early endosomes and in anterograde melanosome transport.{ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236,ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB1A_C7orf50


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB1A_C7orf50


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAB1ARABAC1, GOLGA2, MICAL1, RABIF, GOLGA5, CAPNS1, CREB1, FSCN1, HIVEP1, SLC16A8, TBC1D17, CDKN1A, RFK, CHML, USO1, CHM, RABEP1, ELAVL1, ARRB1, RAB11B, RAB7A, GDI1, GDI2, RAB11A, RAB31, HNRNPA1L2, RAP1A, PTBP1, HNRNPA3, IQCB1, UBL4A, BAG3, ATP4A, ATP6V1A, MTPN, PCYT2, PDIA3, ENO2, GMPS, MTAP, PNP, TUBB4B, RPA1, RPA2, RPA3, ASB5, ASB9, SART3, RUSC2, CUL7, CCDC8, OCRL, ULK1, RAB1B, UNK, ATP1A1, ATP1A2, ATP1A3, ATP1B1, ATP5H, BCAP31, CCDC47, CYC1, DNAJA3, ETFA, HNRNPA1, HSD17B12, IPO9, KDSR, LDHA, LDHAL6B, LDHB, LDHC, LRPPRC, NDUFB8, NDUFB9, PHB, PHPT1, AHSA1, ARF1, ATP1B3, CANX, CDC42, CLGN, DUT, FUBP1, ILVBL, MTCH2, NDUFS8, PLIN3, PRRC1, RAB5A, RAB5B, RAB5C, RANBP1, RAP2C, SLC25A3, SSRP1, STMN1, TECR, TM9SF4, TOMM70A, TXN, RAB2A, RAB6A, RAB6B, RDH13, RER1, RPN1, RPN2, STOML2, STX12, STX7, TMCO1, TMED2, UBE2K, UQCRC2, UQCRQ, VAPA, VDAC2, TCTN2, TCTN3, CAPZA2, DBN1, ATL3, LIMA1, GTSE1, MTOR, RPTOR, CSNK1D, TRAPPC2L, VPS51, TMED10, TSSC1, PTAR1, SEC23IP, COG5, RAB18, VPS52, TRAPPC12, JTB, COG8, RIC1, COG3, COG7, VPS53, TRAPPC13, VPS54, CDC73, CDH1, EGFR, RAB8A, VPS13C, EEF1A2, RABGGTA, RAB2B, DLD, DLST, PARK7, PDHA1, G3BP1, HEY1C7orf50CCDC85B, NEDD4L, HDGF, CUL1, COPS5, CAND1, PRNP, APP, PAXIP1, FBXO25, RPA3, RPA2, RPA1, ADARB1, THAP1, RNF2, HIST1H1A, RPL8, THAP7, PRR11, NTRK1, PCNT, NOP56, NCL, CYLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB1A_C7orf50


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB1A_C7orf50


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource