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Fusion gene ID: 29901 |
FusionGeneSummary for RAB12_MYO5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB12_MYO5B | Fusion gene ID: 29901 | Hgene | Tgene | Gene symbol | RAB12 | MYO5B | Gene ID | 201475 | 4645 |
| Gene name | RAB12, member RAS oncogene family | myosin VB | |
| Synonyms | - | - | |
| Cytomap | 18p11.22 | 18q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related protein Rab-12putative Ras-related protein Rab-12 | unconventional myosin-VbMYO5B variant proteinmyosin-Vb | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6IQ22 | Q9ULV0 | |
| Ensembl transtripts involved in fusion gene | ENST00000329286, | ENST00000285039, ENST00000324581, ENST00000592688, ENST00000587895, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 9 X 9 X 7=567 |
| # samples | 4 | 11 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/567*10)=-2.36584521141757 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAB12 [Title/Abstract] AND MYO5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1R6-01A | RAB12 | chr18 | 8624996 | + | MYO5B | chr18 | 47527781 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000329286 | ENST00000285039 | RAB12 | chr18 | 8624996 | + | MYO5B | chr18 | 47527781 | - |
| 5CDS-intron | ENST00000329286 | ENST00000324581 | RAB12 | chr18 | 8624996 | + | MYO5B | chr18 | 47527781 | - |
| 5CDS-intron | ENST00000329286 | ENST00000592688 | RAB12 | chr18 | 8624996 | + | MYO5B | chr18 | 47527781 | - |
| 5CDS-intron | ENST00000329286 | ENST00000587895 | RAB12 | chr18 | 8624996 | + | MYO5B | chr18 | 47527781 | - |
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FusionProtFeatures for RAB12_MYO5B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB12 | MYO5B |
| The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. That Rab may play a role in proteintransport from recycling endosomes to lysosomes regulating, forinstance, the degradation of the transferrin receptor. Involved inautophagy (By similarity). {ECO:0000250}. | May be involved in vesicular trafficking via itsassociation with the CART complex. The CART complex is necessaryfor efficient transferrin receptor recycling but not for EGFRdegradation. Required in a complex with RAB11A and RAB11FIP2 forthe transport of NPC1L1 to the plasma membrane. Together withRAB11A participates in CFTR trafficking to the plasma membrane andTF (transferrin) recycling in nonpolarized cells. Together withRAB11A and RAB8A participates in epithelial cell polarization.Together with RAB25 regulates transcytosis.{ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAB12 | chr18:8624996 | chr18:47527781 | ENST00000329286 | + | 2 | 6 | 71_79 | 95 | 245 | Motif | Effector region |
| Hgene | RAB12 | chr18:8624996 | chr18:47527781 | ENST00000329286 | + | 2 | 6 | 49_57 | 95 | 245 | Nucleotide binding | Note=GTP |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 1341_1471 | 151 | 1849 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 899_1266 | 151 | 1849 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 801_916 | 151 | 1849 | Compositional bias | Note=Arg-rich |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 1526_1803 | 151 | 1849 | Domain | Dilute |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 769_798 | 151 | 1849 | Domain | IQ 1 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 792_821 | 151 | 1849 | Domain | IQ 2 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 817_848 | 151 | 1849 | Domain | IQ 3 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 840_869 | 151 | 1849 | Domain | IQ 4 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 865_896 | 151 | 1849 | Domain | IQ 5 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 888_917 | 151 | 1849 | Domain | IQ 6 |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 163_170 | 151 | 1849 | Nucleotide binding | ATP |
| Tgene | >MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 640_662 | 151 | 1849 | Region | Actin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RAB12 | chr18:8624996 | chr18:47527781 | ENST00000329286 | + | 2 | 6 | 155_159 | 95 | 245 | Nucleotide binding | Note=GTP |
| Hgene | >RAB12 | chr18:8624996 | chr18:47527781 | ENST00000329286 | + | 2 | 6 | 187_188 | 95 | 245 | Nucleotide binding | Note=GTP |
| Hgene | >RAB12 | chr18:8624996 | chr18:47527781 | ENST00000329286 | + | 2 | 6 | 97_101 | 95 | 245 | Nucleotide binding | GTP |
| Tgene | MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 69_761 | 151 | 1849 | Domain | Myosin motor |
| Tgene | MYO5B | chr18:8624996 | chr18:47527781 | ENST00000285039 | - | 3 | 40 | 8_60 | 151 | 1849 | Domain | Myosin N-terminal SH3-like |
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FusionGeneSequence for RAB12_MYO5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAB12_ENST00000329286_chr18_8624996_+_MYO5B_ENST00000285039_chr18_47527781_-_1793aa MDPGAALQRRAGGGGGLGAGSPALSGGQGRRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKK IRLQIXDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIG ANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIF KIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWI VEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGI LDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDK DPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLET IRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVR GWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATT IQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYT MEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEF AQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGL EKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQ ATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSK TEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNEN LDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGT VPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFD LTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPE IILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAB12_ENST00000329286_chr18_8624996_+_MYO5B_ENST00000285039_chr18_47527781_-_5379nt ATGGATCCGGGCGCCGCGCTGCAGAGGCGGGCCGGGGGCGGCGGCGGTCTGGGCGCGGGCTCCCCGGCGCTGTCGGGCGGCCAGGGCCGC CGGAGGAAGCAGCCCCCCAGGCCGGCCGACTTCAAGTTGCAGGTCATCATTATCGGCTCCCGCGGCGTGGGCAAGACCAGCCTGATGGAG CGCTTCACCGACGACACCTTCTGCGAGGCCTGCAAGTCCACCGTGGGTGTTGACTTCAAAATCAAAACTGTAGAGCTAAGAGGAAAGAAA ATTAGATTACAGATCTGAGATGAGAAGAATCAGTCCATCATAGTCAGTGGGGAGTCTGGAGCCGGGAAGACGGTATCAGCCAAGTATGCC ATGCGCTATTTCGCCACCGTTGGTGGCTCGGCCAGTGAAACCAACATCGAAGAGAAGGTGCTGGCATCCAGTCCCATCATGGAGGCCATT GGAAATGCCAAGACCACCCGCAATGACAACAGCAGCCGTTTTGGCAAGTACATCCAGATTGGCTTTGACAAAAGGTACCACATCATCGGG GCCAACATGAGGACTTACCTCTTGGAGAAGTCCAGAGTGGTCTTCCAGGCAGATGATGAGAGGAATTACCACATCTTTTACCAGCTCTGT GCTGCTGCCGGTCTTCCAGAATTTAAAGAGCTTGCACTAACAAGTGCAGAGGACTTTTTCTATACATCACAGGGAGGAGACACTTCCATC GAGGGTGTGGACGATGCTGAGGACTTTGAGAAGACTCGACAAGCCTTCACACTCCTCGGAGTGAAAGAGTCCCATCAGATGAGCATTTTT AAGATAATTGCTTCTATCTTGCACCTTGGAAGTGTGGCGATTCAGGCTGAGCGTGATGGTGATTCCTGTAGTATATCACCCCAGGATGTA TACCTAAGCAACTTCTGCCGACTGCTAGGGGTGGAGCACAGTCAGATGGAGCACTGGCTGTGTCATCGCAAGCTGGTCACCACCTCGGAG ACCTACGTCAAGACCATGTCCCTGCAGCAGGTGATCAATGCGCGCAACGCCCTGGCGAAGCACATCTATGCCCAGTTGTTCGGCTGGATT GTGGAGCACATCAACAAGGCCCTGCACACCTCCCTCAAGCAGCACTCCTTCATCGGGGTCCTGGACATCTATGGGTTTGAGACATTTGAG GTAAACAGCTTTGAGCAGTTCTGTATCAACTATGCAAATGAAAAGCTCCAGCAGCAGTTCAACTCGCATGTTTTCAAACTGGAGCAAGAA GAATACATGAAGGAACAGATCCCTTGGACCCTGATTGATTTTTATGATAACCAACCTTGTATCGACCTCATTGAAGCCAAGCTGGGTATC TTGGACCTGTTGGATGAAGAATGTAAGGTCCCCAAAGGAACTGACCAGAACTGGGCTCAGAAGCTCTATGACCGGCACTCCAGCAGCCAG CACTTCCAGAAGCCCCGCATGTCCAACACGGCCTTCATCATCGTCCACTTTGCAGACAAGGTGGAGTACCTCTCTGATGGTTTTCTGGAG AAAAACAGAGACACGGTGTATGAAGAGCAGATCAATATCCTGAAGGCCAGCAAGTTCCCACTAGTGGCTGACTTGTTTCATGATGACAAG GACCCTGTTCCTGCCACCACCCCTGGGAAGGGGTCATCTTCGAAGATCAGCGTCCGTTCTGCCAGACCCCCCATGAAAGTCTCCAACAAG GAGCACAAGAAAACCGTTGGCCACCAGTTCCGTACCTCCCTGCATCTGCTCATGGAGACCCTGAATGCCACGACACCTCACTATGTCCGC TGCATCAAGCCCAACGATGAGAAGCTCCCCTTTCACTTTGACCCAAAGAGAGCAGTGCAGCAACTCAGAGCCTGCGGGGTGTTGGAGACG ATTCGAATCAGTGCAGCTGGCTACCCATCCAGGTGGGCCTACCATGACTTTTTCAACCGGTATCGGGTGCTGGTCAAGAAGAGAGAGCTC GCCAACACAGACAAAAAGGCCATCTGCAGGTCTGTCCTGGAGAACCTCATCAAGGACCCCGACAAGTTCCAGTTTGGCCGCACCAAGATC TTCTTTCGAGCAGGCCAGGTGGCCTACCTGGAGAAGCTGCGGGCTGACAAGTTCCGGACAGCCACCATCATGATCCAGAAAACTGTCCGG GGATGGCTGCAGAAGGTGAAATATCACAGGCTGAAGGGGGCTACCTTAACCCTGCAGAGGTACTGCCGGGGACACCTGGCCCGCAGGCTG GCTGAGCACCTGCGGAGGATCAGAGCGGCTGTGGTGCTCCAGAAACATTACCGCATGCAGAGGGCCCGCCAGGCCTACCAGAGGGTCCGC AGAGCTGCCGTTGTTATCCAGGCCTTCACCCGGGCCATGTTTGTGCGGAGAACCTACCGCCAGGTCCTCATGGAGCACAAGGCCACCACC ATCCAGAAGCACGTGCGGGGCTGGATGGCACGCAGGCACTTCCAGCGGCTGCGGGATGCAGCCATTGTCATCCAGTGTGCCTTCCGGATG CTCAAGGCCAGGCGGGAGCTGAAGGCCCTCAGGATTGAGGCCCGCTCAGCAGAGCATCTGAAACGTCTCAACGTGGGCATGGAGAACAAG GTGGTCCAGCTGCAGCGGAAGATCGATGAGCAGAACAAAGAGTTCAAGACACTTTCAGAGCAGTTGTCCGTGACCACCTCAACATACACC ATGGAGGTAGAGCGGCTGAAGAAGGAGCTGGTGCACTACCAGCAGAGCCCAGGTGAGGACACCAGCCTCAGGCTGCAGGAGGAGGTGGAG AGCCTGCGCACAGAGCTGCAGAGGGCCCACTCGGAGCGCAAGATCTTGGAGGACGCCCACAGCAGGGAGAAAGATGAGCTGAGGAAGCGA GTTGCAGACCTGGAGCAAGAAAATGCTCTCTTGAAAGATGAGAAAGAACAGCTCAACAACCAAATCCTGTGCCAGTCTAAAGATGAATTT GCCCAGAACTCTGTGAAGGAAAATCTCATGAAGAAAGAACTGGAGGAGGAGCGATCCCGGTACCAGAACCTTGTGAAGGAATATTCACAG TTGGAGCAGAGATACGACAACCTTCGGGATGAAATGACCATCATAAAGCAAACTCCAGGTCATAGGCGGAACCCATCAAACCAAAGTAGC TTAGAATCTGACTCCAATTACCCCTCCATCTCCACATCTGAGATCGGAGACACTGAGGATGCCCTCCAGCAGGTGGAGGAAATTGGCCTG GAGAAGGCAGCCATGGACATGACGGTCTTCCTGAAGCTGCAGAAGAGAGTACGGGAGCTGGAGCAGGAGAGGAAAAAGCTGCAAGTGCAG CTGGAGAAGAGAGAACAGCAGGACAGCAAGAAAGTCCAGGCGGAACCACCACAGACTGACATAGATTTGGACCCGAATGCAGATCTGGCC TACAATAGTCTGAAGAGGCAAGAGCTGGAGTCAGAGAACAAAAAGCTGAAGAATGACCTGAATGAGCTGAGGAAAGCCGTGGCCGACCAA GCCACGCAGAATAACTCCAGCCACGGCTCCCCAGATAGCTACAGCCTCCTGCTGAACCAGCTCAAGCTGGCCCACGAGGAGCTCGAGGTG CGCAAGGAGGAGGTGCTCATCCTCAGGACCCAGATCGTGAGCGCCGACCAGCGGCGACTCGCCGGCAGGAACGCGGAGCCGAACATTAAT GCCAGATCAAGTTGGCCTAACAGTGAAAAGCATGTTGACCAGGAGGATGCCATTGAGGCCTATCACGGGGTCTGCCAGACAAACAGCAAG ACTGAGGATTGGGGATATTTAAATGAAGATGGAGAACTCGGCTTGGCCTACCAAGGCCTAAAGCAAGTTGCCAGGCTGCTGGAGGCTCAG CTGCAGGCCCAGAGCCTGGAGCATGAGGAGGAGGTGGAGCATCTCAAGGCTCAGCTCGAGGCCCTGAAGGAGGAGATGGACAAACAGCAG CAGACCTTCTGCCAGACGCTACTGCTCTCCCCAGAGGCCCAGGTGGAATTCGGCGTTCAGCAGGAAATATCCCGGCTGACCAACGAGAAT CTGGACCTTAAAGAACTGGTAGAAAAGCTGGAAAAGAATGAGAGGAAGCTCAAAAAGCAACTGAAGATTTACATGAAGAAAGCCCAGGAC CTAGAAGCTGCCCAGGCATTGGCCCAGAGTGAGAGGAAGCGCCATGAGCTCAACAGGCAGGTCACGGTCCAGCGGAAAGAGAAGGATTTC CAGGGCATGCTGGAGTACCACAAAGAGGACGAGGCCCTCCTCATCCGGAACCTGGTGACAGACTTGAAGCCCCAGATGCTGTCGGGCACA GTGCCCTGTCTCCCCGCCTACATCCTCTACATGTGCATCCGGCACGCGGACTACACCAACGACGATCTCAAGGTGCACTCCCTGCTGACC TCCACCATCAACGGCATTAAGAAAGTCCTGAAAAAGCACAATGATGACTTTGAGATGACGTCATTCTGGTTATCCAACACCTGCCGCCTT CTTCACTGTCTGAAGCAGTACAGCGGGGATGAGGGCTTCATGACTCAGAACACTGCAAAGCAGAATGAACACTGTCTTAAGAATTTTGAC CTCACCGAATACCGTCAGGTGCTGAGTGACCTTTCCATTCAGATCTACCAGCAGCTCATTAAAATTGCCGAGGGCGTGTTACAGCCGATG ATAGTTTCTGCCATGTTGGAAAATGAGAGCATTCAGGGTCTATCTGGTGTGAAGCCCACCGGCTACCGGAAGCGCTCCTCCAGCATGGCA GATGGGGATAACTCATACTGCCTGGAAGCTATCATCCGCCAGATGAATGCCTTTCATACAGTCATGTGTGACCAGGGCTTGGACCCTGAG ATCATCCTGCAGGTATTCAAACAGCTCTTCTACATGATCAACGCAGTGACTCTTAACAACCTGCTCTTGCGGAAGGACGTCTGCTCTTGG AGCACAGGCATGCAACTCAGGTACAATATAAGTCAGCTTGAGGAGTGGCTTCGGGGAAGAAACCTTCACCAGAGTGGAGCAGTTCAGACC ATGGAACCTCTGATCCAAGCAGCCCAGCTCCTGCAATTAAAGAAGAAAACCCAGGAGGACGCAGAGGCTATCTGCTCCCTGTGTACCTCC CTCAGCACCCAGCAGATTGTCAAAATTTTAAACCTTTATACTCCCCTGAATGAATTTGAAGAACGGGTAACAGTGGCCTTTATACGAACA ATCCAGGCACAACTACAAGAGCGGAATGACCCTCAGCAACTGCTATTAGATGCCAAGCACATGTTTCCTGTTTTGTTTCCATTTAATCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAB12_ENST00000329286_chr18_8624996_+_MYO5B_ENST00000285039_chr18_47527781_-_9320nt GCTGCCGCTACTGCGGAGTAGCTGCTTCCCTTCCTCCTCTCCCGGCGGCGGCGGCGGCAGCGGCGGAGGAGGAGGAGGAGGGGACCCGGG CGCAGAGAGCCGGCCGGCGGCGCAGTTGCAGCGCGGAGCCCACGGGCCGCCGGGGCCGCTCCAGCGGGCGGAAGCCGAGCCCGGGGCCGA CCCCCCGCGCGCGGCGGAGGCCGAGGGGGCGCCGGGGCCCGGGGCGCGCAGCCGGGGGGCGGGCGGCGGCGGGCGGCGGGCCGAGCGGGA GCCGCATGCGTGTATGGATCCGGGCGCCGCGCTGCAGAGGCGGGCCGGGGGCGGCGGCGGTCTGGGCGCGGGCTCCCCGGCGCTGTCGGG CGGCCAGGGCCGCCGGAGGAAGCAGCCCCCCAGGCCGGCCGACTTCAAGTTGCAGGTCATCATTATCGGCTCCCGCGGCGTGGGCAAGAC CAGCCTGATGGAGCGCTTCACCGACGACACCTTCTGCGAGGCCTGCAAGTCCACCGTGGGTGTTGACTTCAAAATCAAAACTGTAGAGCT AAGAGGAAAGAAAATTAGATTACAGATCTGAGATGAGAAGAATCAGTCCATCATAGTCAGTGGGGAGTCTGGAGCCGGGAAGACGGTATC AGCCAAGTATGCCATGCGCTATTTCGCCACCGTTGGTGGCTCGGCCAGTGAAACCAACATCGAAGAGAAGGTGCTGGCATCCAGTCCCAT CATGGAGGCCATTGGAAATGCCAAGACCACCCGCAATGACAACAGCAGCCGTTTTGGCAAGTACATCCAGATTGGCTTTGACAAAAGGTA CCACATCATCGGGGCCAACATGAGGACTTACCTCTTGGAGAAGTCCAGAGTGGTCTTCCAGGCAGATGATGAGAGGAATTACCACATCTT TTACCAGCTCTGTGCTGCTGCCGGTCTTCCAGAATTTAAAGAGCTTGCACTAACAAGTGCAGAGGACTTTTTCTATACATCACAGGGAGG AGACACTTCCATCGAGGGTGTGGACGATGCTGAGGACTTTGAGAAGACTCGACAAGCCTTCACACTCCTCGGAGTGAAAGAGTCCCATCA GATGAGCATTTTTAAGATAATTGCTTCTATCTTGCACCTTGGAAGTGTGGCGATTCAGGCTGAGCGTGATGGTGATTCCTGTAGTATATC ACCCCAGGATGTATACCTAAGCAACTTCTGCCGACTGCTAGGGGTGGAGCACAGTCAGATGGAGCACTGGCTGTGTCATCGCAAGCTGGT CACCACCTCGGAGACCTACGTCAAGACCATGTCCCTGCAGCAGGTGATCAATGCGCGCAACGCCCTGGCGAAGCACATCTATGCCCAGTT GTTCGGCTGGATTGTGGAGCACATCAACAAGGCCCTGCACACCTCCCTCAAGCAGCACTCCTTCATCGGGGTCCTGGACATCTATGGGTT TGAGACATTTGAGGTAAACAGCTTTGAGCAGTTCTGTATCAACTATGCAAATGAAAAGCTCCAGCAGCAGTTCAACTCGCATGTTTTCAA ACTGGAGCAAGAAGAATACATGAAGGAACAGATCCCTTGGACCCTGATTGATTTTTATGATAACCAACCTTGTATCGACCTCATTGAAGC CAAGCTGGGTATCTTGGACCTGTTGGATGAAGAATGTAAGGTCCCCAAAGGAACTGACCAGAACTGGGCTCAGAAGCTCTATGACCGGCA CTCCAGCAGCCAGCACTTCCAGAAGCCCCGCATGTCCAACACGGCCTTCATCATCGTCCACTTTGCAGACAAGGTGGAGTACCTCTCTGA TGGTTTTCTGGAGAAAAACAGAGACACGGTGTATGAAGAGCAGATCAATATCCTGAAGGCCAGCAAGTTCCCACTAGTGGCTGACTTGTT TCATGATGACAAGGACCCTGTTCCTGCCACCACCCCTGGGAAGGGGTCATCTTCGAAGATCAGCGTCCGTTCTGCCAGACCCCCCATGAA AGTCTCCAACAAGGAGCACAAGAAAACCGTTGGCCACCAGTTCCGTACCTCCCTGCATCTGCTCATGGAGACCCTGAATGCCACGACACC TCACTATGTCCGCTGCATCAAGCCCAACGATGAGAAGCTCCCCTTTCACTTTGACCCAAAGAGAGCAGTGCAGCAACTCAGAGCCTGCGG GGTGTTGGAGACGATTCGAATCAGTGCAGCTGGCTACCCATCCAGGTGGGCCTACCATGACTTTTTCAACCGGTATCGGGTGCTGGTCAA GAAGAGAGAGCTCGCCAACACAGACAAAAAGGCCATCTGCAGGTCTGTCCTGGAGAACCTCATCAAGGACCCCGACAAGTTCCAGTTTGG CCGCACCAAGATCTTCTTTCGAGCAGGCCAGGTGGCCTACCTGGAGAAGCTGCGGGCTGACAAGTTCCGGACAGCCACCATCATGATCCA GAAAACTGTCCGGGGATGGCTGCAGAAGGTGAAATATCACAGGCTGAAGGGGGCTACCTTAACCCTGCAGAGGTACTGCCGGGGACACCT GGCCCGCAGGCTGGCTGAGCACCTGCGGAGGATCAGAGCGGCTGTGGTGCTCCAGAAACATTACCGCATGCAGAGGGCCCGCCAGGCCTA CCAGAGGGTCCGCAGAGCTGCCGTTGTTATCCAGGCCTTCACCCGGGCCATGTTTGTGCGGAGAACCTACCGCCAGGTCCTCATGGAGCA CAAGGCCACCACCATCCAGAAGCACGTGCGGGGCTGGATGGCACGCAGGCACTTCCAGCGGCTGCGGGATGCAGCCATTGTCATCCAGTG TGCCTTCCGGATGCTCAAGGCCAGGCGGGAGCTGAAGGCCCTCAGGATTGAGGCCCGCTCAGCAGAGCATCTGAAACGTCTCAACGTGGG CATGGAGAACAAGGTGGTCCAGCTGCAGCGGAAGATCGATGAGCAGAACAAAGAGTTCAAGACACTTTCAGAGCAGTTGTCCGTGACCAC CTCAACATACACCATGGAGGTAGAGCGGCTGAAGAAGGAGCTGGTGCACTACCAGCAGAGCCCAGGTGAGGACACCAGCCTCAGGCTGCA GGAGGAGGTGGAGAGCCTGCGCACAGAGCTGCAGAGGGCCCACTCGGAGCGCAAGATCTTGGAGGACGCCCACAGCAGGGAGAAAGATGA GCTGAGGAAGCGAGTTGCAGACCTGGAGCAAGAAAATGCTCTCTTGAAAGATGAGAAAGAACAGCTCAACAACCAAATCCTGTGCCAGTC TAAAGATGAATTTGCCCAGAACTCTGTGAAGGAAAATCTCATGAAGAAAGAACTGGAGGAGGAGCGATCCCGGTACCAGAACCTTGTGAA GGAATATTCACAGTTGGAGCAGAGATACGACAACCTTCGGGATGAAATGACCATCATAAAGCAAACTCCAGGTCATAGGCGGAACCCATC AAACCAAAGTAGCTTAGAATCTGACTCCAATTACCCCTCCATCTCCACATCTGAGATCGGAGACACTGAGGATGCCCTCCAGCAGGTGGA GGAAATTGGCCTGGAGAAGGCAGCCATGGACATGACGGTCTTCCTGAAGCTGCAGAAGAGAGTACGGGAGCTGGAGCAGGAGAGGAAAAA GCTGCAAGTGCAGCTGGAGAAGAGAGAACAGCAGGACAGCAAGAAAGTCCAGGCGGAACCACCACAGACTGACATAGATTTGGACCCGAA TGCAGATCTGGCCTACAATAGTCTGAAGAGGCAAGAGCTGGAGTCAGAGAACAAAAAGCTGAAGAATGACCTGAATGAGCTGAGGAAAGC CGTGGCCGACCAAGCCACGCAGAATAACTCCAGCCACGGCTCCCCAGATAGCTACAGCCTCCTGCTGAACCAGCTCAAGCTGGCCCACGA GGAGCTCGAGGTGCGCAAGGAGGAGGTGCTCATCCTCAGGACCCAGATCGTGAGCGCCGACCAGCGGCGACTCGCCGGCAGGAACGCGGA GCCGAACATTAATGCCAGATCAAGTTGGCCTAACAGTGAAAAGCATGTTGACCAGGAGGATGCCATTGAGGCCTATCACGGGGTCTGCCA GACAAACAGCAAGACTGAGGATTGGGGATATTTAAATGAAGATGGAGAACTCGGCTTGGCCTACCAAGGCCTAAAGCAAGTTGCCAGGCT GCTGGAGGCTCAGCTGCAGGCCCAGAGCCTGGAGCATGAGGAGGAGGTGGAGCATCTCAAGGCTCAGCTCGAGGCCCTGAAGGAGGAGAT GGACAAACAGCAGCAGACCTTCTGCCAGACGCTACTGCTCTCCCCAGAGGCCCAGGTGGAATTCGGCGTTCAGCAGGAAATATCCCGGCT GACCAACGAGAATCTGGACCTTAAAGAACTGGTAGAAAAGCTGGAAAAGAATGAGAGGAAGCTCAAAAAGCAACTGAAGATTTACATGAA GAAAGCCCAGGACCTAGAAGCTGCCCAGGCATTGGCCCAGAGTGAGAGGAAGCGCCATGAGCTCAACAGGCAGGTCACGGTCCAGCGGAA AGAGAAGGATTTCCAGGGCATGCTGGAGTACCACAAAGAGGACGAGGCCCTCCTCATCCGGAACCTGGTGACAGACTTGAAGCCCCAGAT GCTGTCGGGCACAGTGCCCTGTCTCCCCGCCTACATCCTCTACATGTGCATCCGGCACGCGGACTACACCAACGACGATCTCAAGGTGCA CTCCCTGCTGACCTCCACCATCAACGGCATTAAGAAAGTCCTGAAAAAGCACAATGATGACTTTGAGATGACGTCATTCTGGTTATCCAA CACCTGCCGCCTTCTTCACTGTCTGAAGCAGTACAGCGGGGATGAGGGCTTCATGACTCAGAACACTGCAAAGCAGAATGAACACTGTCT TAAGAATTTTGACCTCACCGAATACCGTCAGGTGCTGAGTGACCTTTCCATTCAGATCTACCAGCAGCTCATTAAAATTGCCGAGGGCGT GTTACAGCCGATGATAGTTTCTGCCATGTTGGAAAATGAGAGCATTCAGGGTCTATCTGGTGTGAAGCCCACCGGCTACCGGAAGCGCTC CTCCAGCATGGCAGATGGGGATAACTCATACTGCCTGGAAGCTATCATCCGCCAGATGAATGCCTTTCATACAGTCATGTGTGACCAGGG CTTGGACCCTGAGATCATCCTGCAGGTATTCAAACAGCTCTTCTACATGATCAACGCAGTGACTCTTAACAACCTGCTCTTGCGGAAGGA CGTCTGCTCTTGGAGCACAGGCATGCAACTCAGGTACAATATAAGTCAGCTTGAGGAGTGGCTTCGGGGAAGAAACCTTCACCAGAGTGG AGCAGTTCAGACCATGGAACCTCTGATCCAAGCAGCCCAGCTCCTGCAATTAAAGAAGAAAACCCAGGAGGACGCAGAGGCTATCTGCTC CCTGTGTACCTCCCTCAGCACCCAGCAGATTGTCAAAATTTTAAACCTTTATACTCCCCTGAATGAATTTGAAGAACGGGTAACAGTGGC CTTTATACGAACAATCCAGGCACAACTACAAGAGCGGAATGACCCTCAGCAACTGCTATTAGATGCCAAGCACATGTTTCCTGTTTTGTT TCCATTTAATCCATCTTCTCTAACCATGGACTCAATCCACATCCCAGCGTGTCTCAATCTGGAATTCCTCAATGAAGTCTGAAGATGCAT GTTTCCAGCATTAGTTTGATTCCCAATGTGAGCAAGAAGGAAGTATATACAGTAAAGTAAATTCAAGGATCTGTTAAATCTGGTAAAAGT AGATCAAATCAGAGATTGACAGCCTGTGGAGGGTGCTGAACTATACAGAATTAGACACAACTATGTCATTATTTTTTGTACCTACTGCTC AGAATAAAAACACTTGAAATATGGAAGATTTTAAGTTTGATTTCAGTCCAACACATATACATAATTTATAGACACCAAGCAGTCCCCATA GACATATAAAAGGTGTCAATTCTATAAAACGAAGCTGCCTAGTTTTGATCTTTGCATAGAACTAGAGAATGTCCAAATTAAAATACCAAA TATATATAAGTCACATAAATTGCCTTCAAAGGGCTTTAACAAATAATGGTACTAATAACCATGATAATGGCATATACTGACATTTCCCAA AGTTTGCAAACCATAGGTGTGGTTGAGTTTGTGGTGAGATGTTTTAAGAACAAAAATATGGGGATGAGACTTCTGAGAAATATTCCCAAA ATATTTTTTAATGGCTGATTATACACAGACAGTGGTGTAACTGACCTCCAGACCAGACATTTTGAGTACTGGTTTCTGAAGCAAAATTAG AAGTGCCAGTCCTCAGTGTGCTCAAACGCTTTTGTGTTATCTTGATTTAATGGAAGAGATTATTAAAATGCTGCTATCCCAAACTCCAAG TGAGAAAGATGGAAAAATATTTTGTTTCTGATGCTAGTCCATACACTTTCCAAGTCCCACAAAACTTTCACAAAAATGTATATAAGCTAA ATATTAGAAACGGATAACAAACTTGTTTTATTTATAGATGTAAAAACCAAACAAGTCAATATGAAAGCTTTTAATCTCTTAATACCATTA AGCTTCCAGTAAGAGCATCACATAATGCTCTACTGTTCCAGAAACCAAATAGTAAAACAAACTAAAGTTCGCACATCAGATCATCTGAAA AACCTTCAAAAATAATCAGTTCAGGGATATTATACAAAAGTTTGGGTTTTTTTTTTTTAAGAGAATAAAATGGCTTAGGTCAACTTTCCC TTTTCAGGTTATTTTCAACGTTTTTCAAATTTAGCACACAAAAAATTGTAAATATCTCTCCCACAAAATAAGGATTTTAAAAAAGTAATT CAGTAATATAACAGGCTTAGATGTTTGCTGCTCTTAGAATTTTTTTTAACTTGTTTTTGGTTTCTTCAAAAGCAAGCATTCAATTGGAAA CCCATATTCTTTCCACACTTTTTTTTACTGTCTTTTCTGTATTTCTTGATAGCAGTATGCTGTTCCCATAAGAAAAAAATGGTATTTGCA AATCATGGAAGAACAGCCTCTGTATTACATTGAGAAAATAAGATTTATCCATGAATTGGAAGTAGAACAGCCTGCCTTCACCCTCTTTTA CTCAACCACCCAACTTAAAAGGCTCTTGGAAACACAGCACACTCCACGCTACCTTCTGCACTGTGCCCTTAGAGCACAGCTTCCTCAGTT GTTCTCTGCATCTCCTGGGGCTTAGGCCAGTCTTAGCCTGGGTTAAGGCTGCTGACATTGTGTTCCAATCAGTTGTCATGGGCATTATCC CCTCTACATCCACATTAAACATGCCGGCTTCTCTTGGGCATCGGCAGAGCTGTGCCTTTTTCTTTCAGTTACAGTTACATAATCACTGAC GTCCATGACACTTACCCATGGATCCATGTGCTGACTTCATTTAGAAGGCCAATCTAAAACAACTGGGTTTGTGGCTACCTCTTTAAAGTT GTTTGTGAAGGATAATTTGTTTTTTAATGCACTTTAGTTTGAAAGTGAGTCTCTTATGTAAGGACCATCCTTAAAAGACCAAAAATGCCT TGTTAGAGTGTTAAGGAGTTTTGACATGCAGTGGTTCCACAAACACAGTGGCTTACTATCCTTATACACTGTCTTATACCATCATTCTCT CCATCTCTCTTGGTCACTACTCTCTGCTGTCACTGGTTAATCACTAGGTGCCAAGAGCTTACTGAATAAAAGCTTGGCAATTAGAATAAA TGGGGAGGGAAGGACCTTATGAATAGTCCATTTAGCCTAAGAAATGGCAGATTTAGTTCTTCTCTTCCAAAAGATAAAGGTATATCCTGG AATTGTACTTAAAACTTACAGATGACTAACAAATATATACTTTATATGTAGTTAATATTTAGATCTGTCTTATTTAATACTTGGAGGCTA GAAGAAGCATCTTTAGGGGAACTATATAATCTTTTGTTAGCATTTTCTCTGCATTTTAAAAAATCATTTCAATTCAAACATTTATCAGTG TCATGAAATCAGTAATGACTCTTTAACAATTCAGGTTTGAACTCTGCATTAGATGTCTCTTTAATTTTTTAATATTTAAAATTTAGTTGA CATTTTTTTCACCAGGTGCCTTTAGCGGTTACTAAGATAACTGACATCAGTTGTTTCTCTGAAATAAGTGTTGCTGTGGGAATAATTTTA ATGTTCAAGGTGATATCATGGGGGAGTTTTGTCTTTTAAAACATTAGAAGCATTTTAAATATTAAGAATCAAATATTTATAGATCAAAAC TTGTGTTTTAAGTATTATACGGGACCTGTTTACTTATAGTAAATGTGAATGTACACATGAGTTGTTGCTGAAGCTGACAAGCATATTACA TACATGCATTTTCCCTGTGCCCTCATAGTTGCAGTTAGAGTTCCAGTACCTGTAGGCTCACCTGGGAGGCAGATTAGACCCAAAGGTAGA TGTTTTTCCCCTTTCCATGAAGCATGTCAGTGGGAGTTGCTTCCTTTGATTTCCCTAGTACTAAATTTTAAGGCTTTTGTAAAAACAAAA CAAAACTAGGAGCTTGGAACAGTTAAAAATCAACACTGCTACCATCAATTCATCAAATATTTACTTAGAGCTTTCATACATTAAGATTCC AGTAACCAATAAATTAGAATTCATTTCTTCTGCATAAAGTAAATTTTCATACACTTGACCTACTAAGACAGCAAGGGTGTCCTAAATTGA GGCATTTGTATAATGCCTGCATAACTAAATGGTCACTAAAATGGGACAGCATGGGGCAAGACCTTGTAGTTCTTCACAGAATATTTGTGG TCAGTTTCTCCAATTAATTTGCTGCATGAGCCAAATAACCATAATTCACTTTTTATACCCACTGGTGCCATAATTAGAGAATTAGAGGGT GTAGACAGAGGTTAATGCCAATGAGAAACACAGGACAGGGTTTTTTTTATTATAAAGGTCATTAGATACAAAAGATTGTTTTTCAAAAAA TTTCTAATTCTAACAAAGGGGATCAATCAGAAATGAAACTAAGCTACTTTCTAAAGTGACACTGTATCAGAATAATCCAGATTTGAATAT AACATTTTGCCACCAACTGACATTTAGATGAAGGACTGCCTCTCTGAAAGAGTTCAGATCATATTCAGGGGTGAATCCAACACCATGGAA GAAAGACTACTGATGAAAATATTTTCCCACTTTGCACAAATCTGTAAACTACACCTTTGTTTATAGAAAAATGCTTGTAATAGTCACTGT |
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FusionGenePPI for RAB12_MYO5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAB12 | OPTN, GDI1, LRRTM1 | MYO5B | CXCR2, RAB11FIP2, KIAA1549, COIL, PAN2, RAB11A, RAB11B, RAB25, RAB8A, POLR1C, BNIP2, TCF4, AMOTL2, TRIM54, CCDC8, PEX19, LRRC39, TMOD1, CAPZB, CAPZA2, DBN1, MYH9, PPP1CB, IQGAP1, SYNPO, LIMA1, ANLN, MYO19, SKA3, MYO18A, EXOC6, SYTL4, RAB3B, STX3, TBC1D30, EVI5, SSH1, TMOD3, DKK3, MYL2, PPP6R2, PDF, RAC1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB12_MYO5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB12_MYO5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RAB12 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | MYO5B | C0341306 | Microvillus inclusion disease | 5 | CTD_human;ORPHANET;UNIPROT |
| Tgene | MYO5B | C0011991 | Diarrhea | 1 | CTD_human |
| Tgene | MYO5B | C0021831 | Intestinal Diseases | 1 | CTD_human |
| Tgene | MYO5B | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | MYO5B | C0025521 | Inborn Errors of Metabolism | 1 | CTD_human |
| Tgene | MYO5B | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | MYO5B | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | MYO5B | C0525045 | Mood Disorders | 1 | PSYGENET |
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