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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29876

FusionGeneSummary for RAB11B_RRBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB11B_RRBP1
Fusion gene ID: 29876
HgeneTgene
Gene symbol

RAB11B

RRBP1

Gene ID

9230

6238

Gene nameRAB11B, member RAS oncogene familyribosome binding protein 1
SynonymsH-YPT3|NDAGSCWES/130|ES130|RRp|hES
Cytomap

19p13.2

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-11BGTP-binding protein YPT3RAB11B, member of RAS oncogene familyribosome-binding protein 1180 kDa ribosome receptor homologES/130-related proteinribosome binding protein 1 homolog 180kDa (dog)ribosome receptor protein
Modification date2018052320180519
UniProtAcc

Q15907

Q9P2E9

Ensembl transtripts involved in fusion geneENST00000328024, ENST00000601897, 
ENST00000594216, 		ENST00000470422, 
ENST00000246043, ENST00000377813, 
ENST00000377807, ENST00000360807, 
ENST00000455029, 
Fusion gene scores* DoF score7 X 6 X 3=1267 X 9 X 4=252
# samples 710
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB11B [Title/Abstract] AND RRBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB11B

GO:0071468

cellular response to acidic pH

20717956


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI051667RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000328024ENST00000470422RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
3UTR-intronENST00000328024ENST00000246043RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
3UTR-intronENST00000328024ENST00000377813RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
3UTR-intronENST00000328024ENST00000377807RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
3UTR-intronENST00000328024ENST00000360807RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
3UTR-intronENST00000328024ENST00000455029RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000601897ENST00000470422RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000601897ENST00000246043RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000601897ENST00000377813RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000601897ENST00000377807RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000601897ENST00000360807RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000601897ENST00000455029RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000594216ENST00000470422RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000594216ENST00000246043RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000594216ENST00000377813RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000594216ENST00000377807RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000594216ENST00000360807RAB11Bchr19

8468998

-RRBP1chr20

17621075

+
intron-intronENST00000594216ENST00000455029RAB11Bchr19

8468998

-RRBP1chr20

17621075

+

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FusionProtFeatures for RAB11B_RRBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB11B

Q15907

RRBP1

Q9P2E9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB11B_RRBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB11B_RRBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB11B_RRBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB11B_RRBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAB11BC0019693HIV Infections1CTD_human