|
Fusion gene ID: 29747 |
FusionGeneSummary for PWP2_SFSWAP |
Fusion gene summary |
Fusion gene information | Fusion gene name: PWP2_SFSWAP | Fusion gene ID: 29747 | Hgene | Tgene | Gene symbol | PWP2 | SFSWAP | Gene ID | 5822 | 6433 |
Gene name | PWP2, small subunit processome component | splicing factor SWAP | |
Synonyms | EHOC-17|PWP2H|UTP1 | SFRS8|SWAP | |
Cytomap | 21q22.3 | 12q24.33 | |
Type of gene | protein-coding | protein-coding | |
Description | periodic tryptophan protein 2 homologPWP2 periodic tryptophan protein homologPWP2, UTPB SSU processome subunit | splicing factor, suppressor of white-apricot homologsplicing factor SWAP homologsplicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot, Drosophila ho | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15269 | Q12872 | |
Ensembl transtripts involved in fusion gene | ENST00000291576, ENST00000494310, | ENST00000261674, ENST00000541286, ENST00000539506, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 8 X 8=512 |
# samples | 3 | 10 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/512*10)=-2.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PWP2 [Title/Abstract] AND SFSWAP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A08J-01A | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000291576 | ENST00000261674 | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
In-frame | ENST00000291576 | ENST00000541286 | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
5CDS-3UTR | ENST00000291576 | ENST00000539506 | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
intron-3CDS | ENST00000494310 | ENST00000261674 | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
intron-3CDS | ENST00000494310 | ENST00000541286 | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
intron-3UTR | ENST00000494310 | ENST00000539506 | PWP2 | chr21 | 45537844 | + | SFSWAP | chr12 | 132271008 | + |
Top |
FusionProtFeatures for PWP2_SFSWAP |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PWP2 | SFSWAP |
Plays a role as an alternative splicing regulator.Regulate its own expression at the level of RNA processing. Alsoregulates the splicing of fibronectin and CD45 genes. May act, atleast in part, by interaction with other R/S-containing splicingfactors. Represses the splicing of MAPT/Tau exon 10.{ECO:0000269|PubMed:8940107}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 240_247 | 326 | 920 | Compositional bias | Note=Poly-Glu |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 12_50 | 326 | 920 | Repeat | Note=WD 1 |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 142_181 | 326 | 920 | Repeat | Note=WD 4 |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 186_225 | 326 | 920 | Repeat | Note=WD 5 |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 286_325 | 326 | 920 | Repeat | Note=WD 6 |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 53_93 | 326 | 920 | Repeat | Note=WD 2 |
Hgene | PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 94_132 | 326 | 920 | Repeat | Note=WD 3 |
Tgene | >SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 850_853 | 802 | 952 | Compositional bias | Note=Poly-Lys |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 328_368 | 326 | 920 | Repeat | Note=WD 7 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 371_410 | 326 | 920 | Repeat | Note=WD 8 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 413_452 | 326 | 920 | Repeat | Note=WD 9 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 456_498 | 326 | 920 | Repeat | Note=WD 10 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 499_538 | 326 | 920 | Repeat | Note=WD 11 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 541_580 | 326 | 920 | Repeat | Note=WD 12 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 603_642 | 326 | 920 | Repeat | Note=WD 13 |
Hgene | >PWP2 | chr21:45537844 | chr12:132271008 | ENST00000291576 | + | 8 | 21 | 700_740 | 326 | 920 | Repeat | Note=WD 14 |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 165_168 | 802 | 952 | Compositional bias | Note=Poly-Glu |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 287_290 | 802 | 952 | Compositional bias | Note=Poly-Asp |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 382_385 | 802 | 952 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 413_416 | 802 | 952 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 420_424 | 802 | 952 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 434_440 | 802 | 952 | Compositional bias | Note=Poly-Thr |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 451_454 | 802 | 952 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 616_619 | 802 | 952 | Compositional bias | Note=Poly-Ser |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 660_663 | 802 | 952 | Compositional bias | Note=Poly-Ala |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 754_763 | 802 | 952 | Compositional bias | Note=Poly-Lys |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 789_951 | 802 | 952 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 165_168 | 854 | 1004 | Compositional bias | Note=Poly-Glu |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 287_290 | 854 | 1004 | Compositional bias | Note=Poly-Asp |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 382_385 | 854 | 1004 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 413_416 | 854 | 1004 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 420_424 | 854 | 1004 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 434_440 | 854 | 1004 | Compositional bias | Note=Poly-Thr |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 451_454 | 854 | 1004 | Compositional bias | Note=Poly-Pro |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 616_619 | 854 | 1004 | Compositional bias | Note=Poly-Ser |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 660_663 | 854 | 1004 | Compositional bias | Note=Poly-Ala |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 754_763 | 854 | 1004 | Compositional bias | Note=Poly-Lys |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 789_951 | 854 | 1004 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 850_853 | 854 | 1004 | Compositional bias | Note=Poly-Lys |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 211_253 | 802 | 952 | Repeat | Note=SURP motif 1 |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000261674 | + | 13 | 18 | 459_499 | 802 | 952 | Repeat | Note=SURP motif 2 |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 211_253 | 854 | 1004 | Repeat | Note=SURP motif 1 |
Tgene | SFSWAP | chr21:45537844 | chr12:132271008 | ENST00000541286 | + | 14 | 19 | 459_499 | 854 | 1004 | Repeat | Note=SURP motif 2 |
Top |
FusionGeneSequence for PWP2_SFSWAP |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PWP2_ENST00000291576_chr21_45537844_+_SFSWAP_ENST00000261674_chr12_132271008_+_476aa MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVL HHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLI YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTG KVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPG ASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQS >In-frame_PWP2_ENST00000291576_chr21_45537844_+_SFSWAP_ENST00000541286_chr12_132271008_+_476aa MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVL HHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLI YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTG KVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPG ASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PWP2_ENST00000291576_chr21_45537844_+_SFSWAP_ENST00000261674_chr12_132271008_+_1428nt ATGAAGTTCGCTTACCGGTTTTCAAATTTGCTGGGTACGGTGTACCGGCGTGGGAACCTAAATTTTACCTGCGATGGAAATTCAGTTATC AGTCCCGTGGGCAATAGAGTCACTGTATTTGACCTTAAAAACAACAAATCTGACACGCTGCCCCTGGCCACTCGGTACAACGTCAAGTGC GTGGGGCTGTCCCCGGATGGCCGCCTCGCTATCATCGTCGATGAAGGGGGCGATGCGCTGCTGGTCAGCCTGGTCTGCAGGTCTGTGCTG CACCACTTCCACTTCAAGGGCTCTGTGCACAGTGTGTCCTTCTCCCCTGATGGCAGGAAGTTTGTTGTCACAAAGGGTAACATTGCCCAG ATGTATCATGCCCCTGGGAAGAAGCGGGAGTTCAACGCCTTCGTTCTGGACAAGACCTATTTTGGGCCCTACGATGAGACCACCTGCATC GACTGGACGGATGACTCCAGGTGCTTTGTGGTTGGGAGCAAAGACATGTCCACCTGGGTGTTCGGAGCCGAGCGCTGGGACAACCTCATC TACTATGCACTGGGGGGACATAAGGATGCCATCGTGGCCTGCTTCTTTGAATCCAACAGCCTGGACCTGTACTCACTCAGCCAGGACGGA GTGCTGTGCATGTGGCAGTGTGACACGCCCCCCGAGGGCTTGCGGCTGAAGCCCCCTGCGGGCTGGAAAGCAGACCTGTTGCAGCGGGAG GAGGAAGAGGAGGAGGAGGAGGACCAGGAGGGCGACAGAGAGACCACCATCCGGGGAAAAGCCACTCCGGCCGAGGAGGAGAAGACAGGA AAAGTGAAGTACTCACGGCTGGCCAAGTACTTCTTCAATAAAGAAGGGGATTTTAACAACCTGACAGCTGCAGCATTTCATAAGAAGTCT CACCTCTTGGTCACTGGCTTTGCTTCTGGAATCTTCCATCTTCATGAGCTGCCAGAGTTTAACCTCATCCACTCCCTGAGGTCCCGCTCC CGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGG GCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCT CAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAG AGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGC >In-frame_PWP2_ENST00000291576_chr21_45537844_+_SFSWAP_ENST00000541286_chr12_132271008_+_1428nt ATGAAGTTCGCTTACCGGTTTTCAAATTTGCTGGGTACGGTGTACCGGCGTGGGAACCTAAATTTTACCTGCGATGGAAATTCAGTTATC AGTCCCGTGGGCAATAGAGTCACTGTATTTGACCTTAAAAACAACAAATCTGACACGCTGCCCCTGGCCACTCGGTACAACGTCAAGTGC GTGGGGCTGTCCCCGGATGGCCGCCTCGCTATCATCGTCGATGAAGGGGGCGATGCGCTGCTGGTCAGCCTGGTCTGCAGGTCTGTGCTG CACCACTTCCACTTCAAGGGCTCTGTGCACAGTGTGTCCTTCTCCCCTGATGGCAGGAAGTTTGTTGTCACAAAGGGTAACATTGCCCAG ATGTATCATGCCCCTGGGAAGAAGCGGGAGTTCAACGCCTTCGTTCTGGACAAGACCTATTTTGGGCCCTACGATGAGACCACCTGCATC GACTGGACGGATGACTCCAGGTGCTTTGTGGTTGGGAGCAAAGACATGTCCACCTGGGTGTTCGGAGCCGAGCGCTGGGACAACCTCATC TACTATGCACTGGGGGGACATAAGGATGCCATCGTGGCCTGCTTCTTTGAATCCAACAGCCTGGACCTGTACTCACTCAGCCAGGACGGA GTGCTGTGCATGTGGCAGTGTGACACGCCCCCCGAGGGCTTGCGGCTGAAGCCCCCTGCGGGCTGGAAAGCAGACCTGTTGCAGCGGGAG GAGGAAGAGGAGGAGGAGGAGGACCAGGAGGGCGACAGAGAGACCACCATCCGGGGAAAAGCCACTCCGGCCGAGGAGGAGAAGACAGGA AAAGTGAAGTACTCACGGCTGGCCAAGTACTTCTTCAATAAAGAAGGGGATTTTAACAACCTGACAGCTGCAGCATTTCATAAGAAGTCT CACCTCTTGGTCACTGGCTTTGCTTCTGGAATCTTCCATCTTCATGAGCTGCCAGAGTTTAACCTCATCCACTCCCTGAGGTCCCGCTCC CGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGG GCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCT CAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAG AGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PWP2_ENST00000291576_chr21_45537844_+_SFSWAP_ENST00000261674_chr12_132271008_+_1804nt GCGCTGTGGGCGGTGCACGCCGTCGCTTCCCGGAAGTGCGTGCTGTGGGCGGTGCCGCGCGGACCCCCGGGAAGTGTCTCTGTGGGCGGC CGCCGGGTTGAGCTGCGGCACACGTGCGACGGCCGTGATGAAGTTCGCTTACCGGTTTTCAAATTTGCTGGGTACGGTGTACCGGCGTGG GAACCTAAATTTTACCTGCGATGGAAATTCAGTTATCAGTCCCGTGGGCAATAGAGTCACTGTATTTGACCTTAAAAACAACAAATCTGA CACGCTGCCCCTGGCCACTCGGTACAACGTCAAGTGCGTGGGGCTGTCCCCGGATGGCCGCCTCGCTATCATCGTCGATGAAGGGGGCGA TGCGCTGCTGGTCAGCCTGGTCTGCAGGTCTGTGCTGCACCACTTCCACTTCAAGGGCTCTGTGCACAGTGTGTCCTTCTCCCCTGATGG CAGGAAGTTTGTTGTCACAAAGGGTAACATTGCCCAGATGTATCATGCCCCTGGGAAGAAGCGGGAGTTCAACGCCTTCGTTCTGGACAA GACCTATTTTGGGCCCTACGATGAGACCACCTGCATCGACTGGACGGATGACTCCAGGTGCTTTGTGGTTGGGAGCAAAGACATGTCCAC CTGGGTGTTCGGAGCCGAGCGCTGGGACAACCTCATCTACTATGCACTGGGGGGACATAAGGATGCCATCGTGGCCTGCTTCTTTGAATC CAACAGCCTGGACCTGTACTCACTCAGCCAGGACGGAGTGCTGTGCATGTGGCAGTGTGACACGCCCCCCGAGGGCTTGCGGCTGAAGCC CCCTGCGGGCTGGAAAGCAGACCTGTTGCAGCGGGAGGAGGAAGAGGAGGAGGAGGAGGACCAGGAGGGCGACAGAGAGACCACCATCCG GGGAAAAGCCACTCCGGCCGAGGAGGAGAAGACAGGAAAAGTGAAGTACTCACGGCTGGCCAAGTACTTCTTCAATAAAGAAGGGGATTT TAACAACCTGACAGCTGCAGCATTTCATAAGAAGTCTCACCTCTTGGTCACTGGCTTTGCTTCTGGAATCTTCCATCTTCATGAGCTGCC AGAGTTTAACCTCATCCACTCCCTGAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAG TGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAG GCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGC CCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGC CCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAA AAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCC GGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGTAAATTAATTTTTGATGACATTTTGAGTTTTAAGATTTCTGA CCAGCAGTCTCTTACCTGTATATTTGTAAATATATCATGTTTCTGTGAAAATGTATTATGAAATAAAATGGGAGGAAACACCTTTTCTAG >In-frame_PWP2_ENST00000291576_chr21_45537844_+_SFSWAP_ENST00000541286_chr12_132271008_+_1669nt GCGCTGTGGGCGGTGCACGCCGTCGCTTCCCGGAAGTGCGTGCTGTGGGCGGTGCCGCGCGGACCCCCGGGAAGTGTCTCTGTGGGCGGC CGCCGGGTTGAGCTGCGGCACACGTGCGACGGCCGTGATGAAGTTCGCTTACCGGTTTTCAAATTTGCTGGGTACGGTGTACCGGCGTGG GAACCTAAATTTTACCTGCGATGGAAATTCAGTTATCAGTCCCGTGGGCAATAGAGTCACTGTATTTGACCTTAAAAACAACAAATCTGA CACGCTGCCCCTGGCCACTCGGTACAACGTCAAGTGCGTGGGGCTGTCCCCGGATGGCCGCCTCGCTATCATCGTCGATGAAGGGGGCGA TGCGCTGCTGGTCAGCCTGGTCTGCAGGTCTGTGCTGCACCACTTCCACTTCAAGGGCTCTGTGCACAGTGTGTCCTTCTCCCCTGATGG CAGGAAGTTTGTTGTCACAAAGGGTAACATTGCCCAGATGTATCATGCCCCTGGGAAGAAGCGGGAGTTCAACGCCTTCGTTCTGGACAA GACCTATTTTGGGCCCTACGATGAGACCACCTGCATCGACTGGACGGATGACTCCAGGTGCTTTGTGGTTGGGAGCAAAGACATGTCCAC CTGGGTGTTCGGAGCCGAGCGCTGGGACAACCTCATCTACTATGCACTGGGGGGACATAAGGATGCCATCGTGGCCTGCTTCTTTGAATC CAACAGCCTGGACCTGTACTCACTCAGCCAGGACGGAGTGCTGTGCATGTGGCAGTGTGACACGCCCCCCGAGGGCTTGCGGCTGAAGCC CCCTGCGGGCTGGAAAGCAGACCTGTTGCAGCGGGAGGAGGAAGAGGAGGAGGAGGAGGACCAGGAGGGCGACAGAGAGACCACCATCCG GGGAAAAGCCACTCCGGCCGAGGAGGAGAAGACAGGAAAAGTGAAGTACTCACGGCTGGCCAAGTACTTCTTCAATAAAGAAGGGGATTT TAACAACCTGACAGCTGCAGCATTTCATAAGAAGTCTCACCTCTTGGTCACTGGCTTTGCTTCTGGAATCTTCCATCTTCATGAGCTGCC AGAGTTTAACCTCATCCACTCCCTGAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAG TGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAG GCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGC CCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGC CCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAA AAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCC |
Top |
FusionGenePPI for PWP2_SFSWAP |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PWP2 | TOM1L1, USP36, HDGF, SIRT7, CUL3, CUL1, WDR36, RRP9, IPO13, MMS19, TARDBP, HECW2, CUL7, OBSL1, EED, RNF2, FBL, MPHOSPH10, BYSL, DDX18, IMP3, WDR3, TBL3, IFI16, B9D2, CNTRL, CEP19, XPO1, BAG6, ZNF746, TMEM206, GYPB, FGF8, FGF3, MECP2, ZNF71, DNAJC7, RBM4, BBS7, GPATCH4, ZNF692 | SFSWAP | RNPS1, JMJD6, CAND1, EAF1, NTRK1, EWSR1, NEIL3, CFAP20, RBM17, CAPN13, TSEN2, DLST |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PWP2_SFSWAP |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PWP2_SFSWAP |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SFSWAP | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |