FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29669

FusionGeneSummary for PUM1_SDCCAG8

check button Fusion gene summary
Fusion gene informationFusion gene name: PUM1_SDCCAG8
Fusion gene ID: 29669
HgeneTgene
Gene symbol

PUM1

SDCCAG8

Gene ID

9698

10806

Gene namepumilio RNA binding family member 1serologically defined colon cancer antigen 8
SynonymsHSPUM|PUMH|PUMH1|PUML1|SCA47BBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
Cytomap

1p35.2

1q43-q44

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 1pumilio-1serologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
Modification date2018051920180523
UniProtAcc

Q14671

Q86SQ7

Ensembl transtripts involved in fusion geneENST00000424085, ENST00000257075, 
ENST00000373747, ENST00000426105, 
ENST00000440538, ENST00000373741, 
ENST00000423018, ENST00000373742, 
ENST00000490546, 
ENST00000355875, 
ENST00000366541, ENST00000343783, 
ENST00000391846, ENST00000496361, 
Fusion gene scores* DoF score26 X 16 X 15=624013 X 10 X 7=910
# samples 3413
** MAII scorelog2(34/6240*10)=-4.19793937761191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PUM1 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM1

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM1

GO:0043488

regulation of mRNA stability

26724866

HgenePUM1

GO:0051726

regulation of cell cycle

20818387

HgenePUM1

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM1

GO:1900246

positive regulation of RIG-I signaling pathway

25340845

HgenePUM1

GO:2000637

positive regulation of gene silencing by miRNA

20818387|22345517


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5527-01APUM1chr1

31501643

-SDCCAG8chr1

243493842

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000424085ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000424085ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000424085ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000424085ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000424085ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000257075ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000257075ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000257075ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000257075ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000257075ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000373747ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000373747ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000373747ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373747ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373747ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000426105ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000426105ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000426105ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000426105ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000426105ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000440538ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000440538ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000440538ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000440538ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000440538ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373741ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373741ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373741ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373741ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373741ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000423018ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000423018ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000423018ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000423018ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000423018ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373742ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373742ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373742ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373742ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373742ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-3CDSENST00000490546ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-3CDSENST00000490546ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-3CDSENST00000490546ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-intronENST00000490546ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-intronENST00000490546ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+

Top

FusionProtFeatures for PUM1_SDCCAG8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PUM1

Q14671

SDCCAG8

Q86SQ7

Sequence-specific RNA-binding protein that acts as apost-transcriptional repressor by binding the 3'-UTR of mRNAtargets. Binds to an RNA consensus sequence, the Pumilio ResponseElement (PRE), 5'-UGUANAUA-3', that is related to the NanosResponse Element (NRE) (PubMed:21572425, PubMed:18328718,PubMed:21653694, PubMed:21397187). Mediates post-transcriptionalrepression of transcripts via different mechanisms: acts viadirect recruitment of the CCR4-POP2-NOT deadenylase leading totranslational inhibition and mRNA degradation (PubMed:22955276).Also mediates deadenylation-independent repression by promotingaccessibility of miRNAs (PubMed:18776931, PubMed:20818387,PubMed:20860814, PubMed:22345517). Following growth factorstimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222,efficient suppression of CDKN1B/p27 expression, and rapid entry tothe cell cycle (PubMed:20818387). Acts as a post-transcriptionalrepressor of E2F3 mRNAs by binding to its 3'-UTR and facilitatingmiRNA regulation (PubMed:22345517). Represses a program of genesnecessary to maintain genomic stability such as key mitotic, DNArepair and DNA replication factors. Its ability to repress thosetarget mRNAs is regulated by the lncRNA NORAD (non-coding RNAactivated by DNA damage) which, due to its high abundance andmultitude of PUMILIO binding sites, is able to sequester asignificant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). Involved in neuronal functions by regulatingATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1transcripts, leading to their down-regulation independently of themiRNA machinery (PubMed:25768905). Plays a role in cytoplasmicsensing of viral infection (PubMed:25340845). In testis, acts as apost-transcriptional regulator of spermatogenesis by binding tothe 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved inembryonic stem cell renewal by facilitating the exit from theground state: acts by targeting mRNAs coding for naivepluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Bindsspecifically to miRNA MIR199A precursor, with PUM2, regulatesmiRNA MIR199A expression at a postranscriptional level(PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78,ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931,ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814,ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425,ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517,ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845,ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866,ECO:0000269|PubMed:28431233}. Plays a role in the establishment of cell polarity andepithelial lumen formation (By similarity). May play a role inciliogenesis. {ECO:0000250|UniProtKB:Q80UF4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PUM1_SDCCAG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000355875_chr1_243493842_+_538aa
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000366541_chr1_243493842_+_538aa
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000343783_chr1_243493842_+_538aa
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000355875_chr1_243493842_+_538aa
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000366541_chr1_243493842_+_538aa
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000343783_chr1_243493842_+_538aa
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000355875_chr1_243493842_+_1614nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG

>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000366541_chr1_243493842_+_1614nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG

>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000343783_chr1_243493842_+_1614nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000355875_chr1_243493842_+_1614nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000366541_chr1_243493842_+_1614nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000343783_chr1_243493842_+_1614nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000355875_chr1_243493842_+_2121nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAG
AACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGA
TGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGG
AAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGA
AGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAA
TAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGC
TGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCC
TTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGT
TGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCA
GATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAAC
AGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGG
TGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCA
TGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATA
TGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACG
CAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCT

>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000366541_chr1_243493842_+_2127nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAG
AACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGA
TGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGG
AAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGA
AGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAA
TAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGC
TGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCC
TTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGT
TGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCA
GATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAAC
AGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGG
TGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCA
TGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATA
TGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACG
CAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCT

>In-frame_PUM1_ENST00000373741_chr1_31501643_-_SDCCAG8_ENST00000343783_chr1_243493842_+_2125nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAG
AACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGA
TGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGG
AAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGA
AGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAA
TAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGC
TGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCC
TTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGT
TGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCA
GATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAAC
AGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGG
TGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCA
TGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATA
TGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACG
CAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCT

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000355875_chr1_243493842_+_1915nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG
CTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGA
TGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCA
GGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGAC
TCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACAT

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000366541_chr1_243493842_+_1921nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG
CTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGA
TGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCA
GGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGAC
TCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACAT

>In-frame_PUM1_ENST00000373742_chr1_31501643_-_SDCCAG8_ENST00000343783_chr1_243493842_+_1919nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG
CTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGA
TGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCA
GGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGAC
TCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACAT


Top

FusionGenePPI for PUM1_SDCCAG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PUM1ELAVL1, SIRT7, CAND1, ATXN1, LAGE3, CLNS1A, PAICS, ANXA5, HSPB1, VPS26A, SEPHS1, DSTN, SMAD1, ITGA4, EIF5, PRR12, FBXO6, SAV1, YWHAB, AURKB, CDKN1A, CCDC8, BMI1, EGFR, RBFOX2, FBXW11, NTRK1, KIAA0753, XPO1, MATR3, SEC16A, FOXG1, FOXI2, FOXQ1, RC3H1, EYA2, ELAVL2, TRIM11, CELF5, LITAF, CLASRP, TRIM25, G3BP1SDCCAG8CEP192, SCARA3, KRAS, TENC1, OFD1, IKBKG, CCDC120, LARS, KARS, UBE2N


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PUM1_SDCCAG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PUM1_SDCCAG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSDCCAG8C0035309Retinal Diseases1CTD_human
TgeneSDCCAG8C0036341Schizophrenia1PSYGENET
TgeneSDCCAG8C1691228Cystic Kidney Diseases1CTD_human