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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29609

FusionGeneSummary for PTPRVP_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRVP_MBP
Fusion gene ID: 29609
HgeneTgene
Gene symbol

PTPRVP

MBP

Gene ID

148713

5553

Gene nameprotein tyrosine phosphatase, receptor type V, pseudogeneproteoglycan 2, pro eosinophil major basic protein
SynonymsESP|OST-PTP|PTPRVBMPG|MBP|MBP1|proMBP
Cytomap

1q32.1

11q12.1

Type of genepseudoprotein-coding
Description-bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018032920180519
UniProtAcc

P02686

Ensembl transtripts involved in fusion geneENST00000482597, ENST00000382582, 
ENST00000355994, ENST00000397875, 
ENST00000397866, ENST00000397865, 
ENST00000527041, ENST00000359645, 
ENST00000528160, ENST00000397869, 
ENST00000354542, ENST00000526111, 
ENST00000580402, ENST00000579129, 
ENST00000578193, ENST00000397863, 
ENST00000397860, ENST00000487778, 
Fusion gene scores* DoF score1 X 1 X 1=126 X 20 X 3=1560
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRVP [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EB387673PTPRVPchr1

202157017

+MBPchr18

74691240

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000482597ENST00000382582PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-3UTRENST00000482597ENST00000355994PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-3UTRENST00000482597ENST00000397875PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-3UTRENST00000482597ENST00000397866PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-3UTRENST00000482597ENST00000397865PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000527041PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000359645PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000528160PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000397869PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000354542PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000526111PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000580402PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000579129PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000578193PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000397863PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000397860PTPRVPchr1

202157017

+MBPchr18

74691240

-
intron-intronENST00000482597ENST00000487778PTPRVPchr1

202157017

+MBPchr18

74691240

-

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FusionProtFeatures for PTPRVP_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRVP

MBP

P02686

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRVP_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRVP_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRVP_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRVP_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human