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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29606

FusionGeneSummary for PTPRU_NOS1AP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRU_NOS1AP
Fusion gene ID: 29606
HgeneTgene
Gene symbol

PTPRU

NOS1AP

Gene ID

10076

9722

Gene nameprotein tyrosine phosphatase, receptor type Unitric oxide synthase 1 adaptor protein
SynonymsFMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-J6330408P19Rik|CAPON
Cytomap

1p35.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronrcarboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with car
Modification date2018052220180519
UniProtAcc

Q92729

O75052

Ensembl transtripts involved in fusion geneENST00000345512, ENST00000373779, 
ENST00000356870, ENST00000323874, 
ENST00000428026, ENST00000460170, 
ENST00000415600, 
ENST00000530878, 
ENST00000361897, ENST00000493151, 
ENST00000454693, 
Fusion gene scores* DoF score6 X 5 X 6=1806 X 5 X 6=180
# samples 66
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRU [Title/Abstract] AND NOS1AP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRU

GO:0006470

protein dephosphorylation

12501215

HgenePTPRU

GO:0008285

negative regulation of cell proliferation

16574648

HgenePTPRU

GO:0030336

negative regulation of cell migration

12501215|16574648

HgenePTPRU

GO:0034394

protein localization to cell surface

16574648

HgenePTPRU

GO:0060070

canonical Wnt signaling pathway

16574648

HgenePTPRU

GO:0098609

cell-cell adhesion

16574648


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-B0-4698-01APTPRUchr1

29618538

+NOS1APchr1

162124195

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000345512ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000345512ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000345512ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000345512ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000373779ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000373779ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000373779ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000373779ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000356870ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000356870ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000356870ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000356870ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000323874ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000323874ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000323874ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000323874ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000428026ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000428026ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000428026ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000428026ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000460170ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
Frame-shiftENST00000460170ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000460170ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
5CDS-intronENST00000460170ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+
3UTR-3CDSENST00000415600ENST00000530878PTPRUchr1

29618538

+NOS1APchr1

162124195

+
3UTR-3CDSENST00000415600ENST00000361897PTPRUchr1

29618538

+NOS1APchr1

162124195

+
3UTR-intronENST00000415600ENST00000493151PTPRUchr1

29618538

+NOS1APchr1

162124195

+
3UTR-intronENST00000415600ENST00000454693PTPRUchr1

29618538

+NOS1APchr1

162124195

+

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FusionProtFeatures for PTPRU_NOS1AP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRU

Q92729

NOS1AP

O75052

Adapter protein involved in neuronal nitric-oxide (NO)synthesis regulation via its association with nNOS/NOS1. Thecomplex formed with NOS1 and synapsins is necessary for specificNO and synapsin functions at a presynaptic level. Mediates anindirect interaction between NOS1 and RASD1 leading to enhance theability of NOS1 to activate RASD1. Competes with DLG4 forinteraction with NOS1, possibly affecting NOS1 activity byregulating the interaction between NOS1 and DLG4 (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRU_NOS1AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRU_NOS1AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRUCTNNB1, IRS1, SGCA, AAMP, EGFR, ERBB2, ARL2, ARHGAP5, NHS, NHSL1, ST7, TMEM57, ABI2, PTPRK, GOLIM4, PCDHGB1, FAM19A4, CLEC2D, ZNRF4, CDH5, SCGB1D1, PCDHGB4NOS1APLRP2, LRP1, LRP8, RASD1, SYN1, SYN2, SYN3, NOS1, APP, TRAF4, FAM133A, EAF1, AP2M1, AKNAD1, NHP2, NKAP, CT45A5, RYBP, CKM, FYN, HSPD1, PLAGL2, PNP, BTRC, XPO1, PCNA, RAB5C, RALA, SNCA, YWHAH, PRPF4, TOMM40, RNPS1, NAF1, KLC3, PTPRH, PTPRJ, C11orf57, ZCCHC17, DDX41, MDK, PLK1, SREK1IP1, GPR156, C1orf186, AKAP17A, PNN, PIP4K2A, OIP5, CAMKV, TRPC4AP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRU_NOS1AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRU_NOS1AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNOS1APC0036341Schizophrenia2PSYGENET