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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29599

FusionGeneSummary for PTPRT_NCOA3

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRT_NCOA3
Fusion gene ID: 29599
HgeneTgene
Gene symbol

PTPRT

NCOA3

Gene ID

11122

8202

Gene nameprotein tyrosine phosphatase, receptor type Tnuclear receptor coactivator 3
SynonymsRPTPrhoACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP
Cytomap

20q12-q13.11

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rhonuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1
Modification date2018051920180523
UniProtAcc

O14522

Q9Y6Q9

Ensembl transtripts involved in fusion geneENST00000373184, ENST00000373187, 
ENST00000356100, ENST00000373190, 
ENST00000373193, ENST00000373198, 
ENST00000373201, ENST00000485499, 
ENST00000341724, ENST00000372004, 
ENST00000371998, ENST00000371997, 
ENST00000497292, 
Fusion gene scores* DoF score5 X 5 X 4=1009 X 6 X 4=216
# samples 69
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRT [Title/Abstract] AND NCOA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRT

GO:0006470

protein dephosphorylation

16973135

HgenePTPRT

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

18644975

TgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

TgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A15F-01APTPRTchr20

40944363

-NCOA3chr20

46211927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373184ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373184ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373184ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373184ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000373184ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373187ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373187ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373187ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373187ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000373187ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000356100ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000356100ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000356100ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000356100ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000356100ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373190ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373190ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373190ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373190ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000373190ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373193ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373193ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373193ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373193ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000373193ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373198ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373198ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373198ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373198ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000373198ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373201ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373201ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373201ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-5UTRENST00000373201ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
5CDS-intronENST00000373201ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+
intron-5UTRENST00000485499ENST00000341724PTPRTchr20

40944363

-NCOA3chr20

46211927

+
intron-5UTRENST00000485499ENST00000372004PTPRTchr20

40944363

-NCOA3chr20

46211927

+
intron-5UTRENST00000485499ENST00000371998PTPRTchr20

40944363

-NCOA3chr20

46211927

+
intron-5UTRENST00000485499ENST00000371997PTPRTchr20

40944363

-NCOA3chr20

46211927

+
intron-intronENST00000485499ENST00000497292PTPRTchr20

40944363

-NCOA3chr20

46211927

+

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FusionProtFeatures for PTPRT_NCOA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRT

O14522

NCOA3

Q9Y6Q9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRT_NCOA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRT_NCOA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRTCUL3, EGFR, ERBB2, ERBB4, ATP2A2, PHKA1, PHKBNCOA3AR, BRCA1, EP300, ANKRD11, NPAS2, NR3C1, YWHAQ, PRMT1, NR4A1, NR2F1, RXRA, CCND1, ESRRA, ESRRB, NKX2-1, CREBBP, ESR1, ESR2, NR0B2, NR5A2, NCOA2, TRIM21, IKBKG, IKBKB, CHUK, VDR, PGR, HIST3H3, HIST4H4, CARM1, ABL1, FOS, NCOR1, ETS1, ETS2, PPARG, NCOA1, THRA, STAT6, SMAD2, SMAD3, ATAD2, KAT2B, RARA, NCOR2, SPOP, CDKN3, IQCK, BRE, DCTN6, CSNK1E, RARG, NR1H3, NR1H2, THRB, SPTA1, MYH9, ACTA1, ANXA2, TPR, MORC2, NFATC3, PSME3, EIF3E, CUL3, NFKB1, MAPK14, MAPK1, MAPK8, GSK3B, RFX1, TP53BP1, PSMC5, PRKCZ, TFF1, PSMA3, MYOCD, CEBPA, CEBPD, UBE3A, E2F1, PIN1, ELAVL1, TP53, KANK2, NR1I2, ALB, MMS19, PTEN, FBXW7, ARNT2, PSMB9, ETV1, PPARD, PPARA, NR1I3, MN1, MKL1, MKL2, HNF1A, RELA, EWSR1, XPO1, XRCC5, TMEM132A, PIAS1, RAB28, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRT_NCOA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRT_NCOA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNCOA3C0023418leukemia2CTD_human
TgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
TgeneNCOA3C0001418Adenocarcinoma1CTD_human
TgeneNCOA3C0004114Astrocytoma1CTD_human
TgeneNCOA3C0005967Bone neoplasms1CTD_human
TgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
TgeneNCOA3C1458155Mammary Neoplasms1CTD_human