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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29585

FusionGeneSummary for PTPRR_SLC6A15

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRR_SLC6A15
Fusion gene ID: 29585
HgeneTgene
Gene symbol

PTPRR

SLC6A15

Gene ID

5801

55117

Gene nameprotein tyrosine phosphatase, receptor type Rsolute carrier family 6 member 15
SynonymsEC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQNTT73|SBAT1|V7-3|hv7-3
Cytomap

12q15

12q21.31

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1sodium-dependent neutral amino acid transporter B(0)AT2homolog of rat orphan transporter v7-3orphan sodium- and chloride-dependent neurotransmitter transporter NTT73orphan transporter v7-3sodium- and chloride-dependent neurotransmitter transporter NTT
Modification date2018051920180523
UniProtAcc

Q15256

Q9H2J7

Ensembl transtripts involved in fusion geneENST00000283228, ENST00000440835, 
ENST00000537619, ENST00000378778, 
ENST00000342084, ENST00000549308, 
ENST00000309283, ENST00000266682, 
ENST00000552192, ENST00000551388, 
ENST00000450363, 
Fusion gene scores* DoF score12 X 9 X 4=4326 X 4 X 2=48
# samples 124
** MAII scorelog2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRR [Title/Abstract] AND SLC6A15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC6A15

GO:0015804

neutral amino acid transport

16226721


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LT-01APTPRRchr12

71147971

-SLC6A15chr12

85286087

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283228ENST00000309283PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000283228ENST00000266682PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000283228ENST00000552192PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000283228ENST00000551388PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000283228ENST00000450363PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000440835ENST00000309283PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000440835ENST00000266682PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000440835ENST00000552192PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000440835ENST00000551388PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000440835ENST00000450363PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
intron-intronENST00000537619ENST00000309283PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
intron-5UTRENST00000537619ENST00000266682PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
intron-intronENST00000537619ENST00000552192PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
intron-intronENST00000537619ENST00000551388PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
intron-5UTRENST00000537619ENST00000450363PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000378778ENST00000309283PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000378778ENST00000266682PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000378778ENST00000552192PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000378778ENST00000551388PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000378778ENST00000450363PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000342084ENST00000309283PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000342084ENST00000266682PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000342084ENST00000552192PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000342084ENST00000551388PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000342084ENST00000450363PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000549308ENST00000309283PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000549308ENST00000266682PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000549308ENST00000552192PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-intronENST00000549308ENST00000551388PTPRRchr12

71147971

-SLC6A15chr12

85286087

-
5CDS-5UTRENST00000549308ENST00000450363PTPRRchr12

71147971

-SLC6A15chr12

85286087

-

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FusionProtFeatures for PTPRR_SLC6A15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRR

Q15256

SLC6A15

Q9H2J7

Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}. Functions as a sodium-dependent neutral amino acidtransporter. Exhibits preference for the branched-chain aminoacids, particularly leucine, valine and isoleucine and methionine.Mediates the saturable, pH-sensitive and electrogenic cotransportof proline and sodium ions with a stoichiometry of 1:1. May have arole as transporter for neurotransmitter precursors into neurons.In contrast to other members of the neurotransmitter transporterfamily, does not appear to be chloride-dependent.{ECO:0000269|PubMed:16226721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRR_SLC6A15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRR_SLC6A15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2SLC6A15LNX1, TEX29, VAPB, TMEM17, TMEM216, PPM1H, TEX2, KLHL36, TLCD1, SFXN5, TMTC4, GOLGA5, AGPAT3, AGPAT9, CAV1, TMPPE, PTPLB, AGPAT2, PTRH2, ALG8, SPPL3, PXMP2, ACSL4, EBP, GPR89A, ATP8B2, PIGU, ARL6IP5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRR_SLC6A15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRR_SLC6A15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRRC0041696Unipolar Depression1PSYGENET
HgenePTPRRC1269683Major Depressive Disorder1PSYGENET
TgeneSLC6A15C0041696Unipolar Depression3PSYGENET
TgeneSLC6A15C1269683Major Depressive Disorder2PSYGENET