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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29582

FusionGeneSummary for PTPRR_FAM19A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRR_FAM19A2
Fusion gene ID: 29582
HgeneTgene
Gene symbol

PTPRR

FAM19A2

Gene ID

5801

338811

Gene nameprotein tyrosine phosphatase, receptor type Rfamily with sequence similarity 19 member A2, C-C motif chemokine like
SynonymsEC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQTAFA-2|TAFA2
Cytomap

12q15

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1protein FAM19A2chemokine-like protein TAFA-2family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
Modification date2018051920180519
UniProtAcc

Q15256

Q8N3H0

Ensembl transtripts involved in fusion geneENST00000283228, ENST00000440835, 
ENST00000537619, ENST00000378778, 
ENST00000342084, ENST00000549308, 
ENST00000416284, ENST00000551619, 
ENST00000550003, ENST00000551449, 
ENST00000549456, 
Fusion gene scores* DoF score12 X 9 X 4=43211 X 6 X 5=330
# samples 1210
** MAII scorelog2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/330*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRR [Title/Abstract] AND FAM19A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2F-01APTPRRchr12

71139598

-FAM19A2chr12

62417560

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283228ENST00000416284PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-5UTRENST00000283228ENST00000551619PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000283228ENST00000550003PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000283228ENST00000551449PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000283228ENST00000549456PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000440835ENST00000416284PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-5UTRENST00000440835ENST00000551619PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000440835ENST00000550003PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000440835ENST00000551449PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000440835ENST00000549456PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
intron-intronENST00000537619ENST00000416284PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
intron-5UTRENST00000537619ENST00000551619PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
intron-intronENST00000537619ENST00000550003PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
intron-intronENST00000537619ENST00000551449PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
intron-intronENST00000537619ENST00000549456PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000378778ENST00000416284PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-5UTRENST00000378778ENST00000551619PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000378778ENST00000550003PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000378778ENST00000551449PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000378778ENST00000549456PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000342084ENST00000416284PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-5UTRENST00000342084ENST00000551619PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000342084ENST00000550003PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000342084ENST00000551449PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000342084ENST00000549456PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000549308ENST00000416284PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-5UTRENST00000549308ENST00000551619PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000549308ENST00000550003PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000549308ENST00000551449PTPRRchr12

71139598

-FAM19A2chr12

62417560

-
5CDS-intronENST00000549308ENST00000549456PTPRRchr12

71139598

-FAM19A2chr12

62417560

-

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FusionProtFeatures for PTPRR_FAM19A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRR

Q15256

FAM19A2

Q8N3H0

Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRR_FAM19A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRR_FAM19A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2FAM19A2TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRR_FAM19A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRR_FAM19A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRRC0041696Unipolar Depression1PSYGENET
HgenePTPRRC1269683Major Depressive Disorder1PSYGENET