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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29565

FusionGeneSummary for PTPRN2_DNAJC2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRN2_DNAJC2
Fusion gene ID: 29565
HgeneTgene
Gene symbol

PTPRN2

DNAJC2

Gene ID

5799

27000

Gene nameprotein tyrosine phosphatase, receptor type N2DnaJ heat shock protein family (Hsp40) member C2
SynonymsIA-2beta|IAR|ICAAR|PTPRP|R-PTP-N2MPHOSPH11|MPP11|ZRF1|ZUO1
Cytomap

7q36.3

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase N2IAR/receptor-like protein-tyrosine phosphataseislet cell autoantigen-related proteinphogrinprotein tyrosine phosphatase receptor piprotein tyrosine phosphatase, receptor type, N polypeptide 2tyrosine phosdnaJ homolog subfamily C member 2DnaJ (Hsp40) homolog, subfamily C, member 2M-phase phosphoprotein 11zuotin-related factor 1
Modification date2018051920180519
UniProtAcc

Q92932

Q99543

Ensembl transtripts involved in fusion geneENST00000389413, ENST00000409483, 
ENST00000389416, ENST00000389418, 
ENST00000404321, 
ENST00000249270, 
ENST00000379263, ENST00000412522, 
Fusion gene scores* DoF score9 X 9 X 5=4053 X 4 X 2=24
# samples 102
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/24*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRN2 [Title/Abstract] AND DNAJC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNAJC2

GO:0045893

positive regulation of transcription, DNA-templated

21179169


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-D7-6527-01APTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000389413ENST00000249270PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000389413ENST00000379263PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
5CDS-intronENST00000389413ENST00000412522PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000409483ENST00000249270PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000409483ENST00000379263PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
5CDS-intronENST00000409483ENST00000412522PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000389416ENST00000249270PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000389416ENST00000379263PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
5CDS-intronENST00000389416ENST00000412522PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000389418ENST00000249270PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
Frame-shiftENST00000389418ENST00000379263PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
5CDS-intronENST00000389418ENST00000412522PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
intron-3CDSENST00000404321ENST00000249270PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
intron-3CDSENST00000404321ENST00000379263PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-
intron-intronENST00000404321ENST00000412522PTPRN2chr7

158380250

-DNAJC2chr7

102953548

-

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FusionProtFeatures for PTPRN2_DNAJC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRN2

Q92932

DNAJC2

Q99543

Plays a role in vesicle-mediated secretory processes.Required for normal accumulation of secretory vesicles inhippocampus, pituitary and pancreatic islets. Required for theaccumulation of normal levels of insulin-containing vesicles andpreventing their degradation. Plays a role in insulin secretion inresponse to glucose stimuli. Required for normal accumulation ofthe neurotransmitters norepinephrine, dopamine and serotonin inthe brain. In females, but not in males, required for normalaccumulation and secretion of pituitary hormones, such asluteinizing hormone (LH) and follicle-stimulating hormone (FSH)(By similarity). Required to maintain normal levels of reninexpression and renin release (By similarity). May regulatecatalytic active protein-tyrosine phosphatases such as PTPRAthrough dimerization (By similarity). Has phosphatidylinositolphosphatase activity; the PIPase activity is involved in itsability to regulate insulin secretion. Can dephosphorylatephosphatidylinositol 4,5-biphosphate (PI(4,5)P2),phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasmamembrane and localization of cofilin at the plasma membrane andthus is indirectly involved in regulation of actin dynamicsrelated to cell migration and metastasis; upon hydrolyzation ofPI(4,5)P2 cofilin is released from the plasma membrane and acts inthe cytoplasm in severing F-actin filaments (PubMed:26620550).{ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475,ECO:0000269|PubMed:26620550}. Acts both as a chaperone in the cytosol and as achromatin regulator in the nucleus. When cytosolic, acts as amolecular chaperone: component of the ribosome-associated complex(RAC), a complex involved in folding or maintaining nascentpolypeptides in a folding-competent state. In the RAC complex,stimulates the ATPase activity of the ribosome-associated pool ofHsp70-type chaperones HSPA14 that bind to the nascent polypeptidechain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited athistone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotesthe displacement of the polycomb PRC1 complex from chromatin,thereby facilitating transcription activation. Specifically bindsDNA sequence 5'-GTCAAGC-3'. {ECO:0000269|PubMed:15802566,ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRN2_DNAJC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRN2_DNAJC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRN2SPTBN4, CKAP5, UBQLN4, FBXW7, CPSF3L, MON2, MOSPD2, SEC61A1, SORT1, TELO2, HID1, SNX19, KRT17, HGS, KRT16, STAM, HSPA5, STIM1, CLCC1, STAM2, KRT14, GOLGA4, ANKLE2, NUP155, PTPRNDNAJC2HIST2H2AA3, RNF2, DDX5, BANF1, FKBP2, HSPA5, HSPA8, SFTPD, WDR61, DNMT1, HSPA14, HSPA4L, HYOU1, MYO6, NTRK1, SGTB, HYPK, GTF2E2, USP47, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRN2_DNAJC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRN2_DNAJC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource