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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29525

FusionGeneSummary for PTPRJ_MED26

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRJ_MED26
Fusion gene ID: 29525
HgeneTgene
Gene symbol

PTPRJ

MED26

Gene ID

5795

9441

Gene nameprotein tyrosine phosphatase, receptor type Jmediator complex subunit 26
SynonymsCD148|DEP1|HPTPeta|R-PTP-ETA|SCC1CRSP7|CRSP70
Cytomap

11p11.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase etaCD148 antigenDEP-1HPTP etaR-PTP-Jdensity-enhanced phosphatase 1human density enhanced phosphatase-1protein tyrosine phosphatase, receptor type, J polypeptideprotein-tyrosine phosphatase etasusceptibilmediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit
Modification date2018052220180523
UniProtAcc

Q12913

O95402

Ensembl transtripts involved in fusion geneENST00000418331, ENST00000440289, 
ENST00000526550, 
ENST00000263390, 
Fusion gene scores* DoF score6 X 6 X 5=1805 X 5 X 2=50
# samples 76
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPRJ [Title/Abstract] AND MED26 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRJ

GO:0008285

negative regulation of cell proliferation

14709717|16682945|16778204

HgenePTPRJ

GO:0010642

negative regulation of platelet-derived growth factor receptor signaling pathway

14709717

HgenePTPRJ

GO:0030308

negative regulation of cell growth

14709717

HgenePTPRJ

GO:0030336

negative regulation of cell migration

16682945

HgenePTPRJ

GO:0035335

peptidyl-tyrosine dephosphorylation

9531590|10821867|12913111|16778204|18348712|18936167|19332538

HgenePTPRJ

GO:0043116

negative regulation of vascular permeability

19332538

HgenePTPRJ

GO:0043407

negative regulation of MAP kinase activity

19494114

HgenePTPRJ

GO:0050860

negative regulation of T cell receptor signaling pathway

12913111

HgenePTPRJ

GO:0050918

positive chemotaxis

14709717

TgeneMED26

GO:0006357

regulation of transcription by RNA polymerase II

15989967


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI019721PTPRJchr11

48018427

+MED26chr19

16706400

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000418331ENST00000263390PTPRJchr11

48018427

+MED26chr19

16706400

-
intron-intronENST00000440289ENST00000263390PTPRJchr11

48018427

+MED26chr19

16706400

-
intron-intronENST00000526550ENST00000263390PTPRJchr11

48018427

+MED26chr19

16706400

-

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FusionProtFeatures for PTPRJ_MED26


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRJ

Q12913

MED26

O95402

Tyrosine phosphatase which dephosphorylates orcontributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET,RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1,OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration,proliferation and differentiation. Involved in vasculardevelopment. Regulator of macrophage adhesion and spreading.Positively affects cell-matrix adhesion. Positive regulator ofplatelet activation and thrombosis. Negative regulator of cellproliferation. Negative regulator of PDGF-stimulated cellmigration; through dephosphorylation of PDGFR. Positive regulatorof endothelial cell survival, as well as of VEGF-induced SRC andAKT activation; through KDR dephosphorylation. Negative regulatorof EGFR signaling pathway; through EGFR dephosphorylation.Enhances the barrier function of epithelial junctions duringreassembly. Negatively regulates T-cell receptor (TCR) signaling.Upon T-cell TCR activation, it is up-regulated and excluded fromthe immunological synapses, while upon T-cell-antigen presentingcells (APC) disengagement, it is no longer excluded and candephosphorylate PLCG1 and LAT to down-regulate prolongation ofsignaling. {ECO:0000269|PubMed:10821867,ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403,ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979,ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717,ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:16778204,ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167,ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114,ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411,ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971,ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}. Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpre-initiation complex with RNA polymerase II and the generaltranscription factors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRJ_MED26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRJ_MED26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRJ_MED26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRJ_MED26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource