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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29521

FusionGeneSummary for PTPRG_SYNPR

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG_SYNPR
Fusion gene ID: 29521
HgeneTgene
Gene symbol

PTPRG

SYNPR

Gene ID

5793

132204

Gene nameprotein tyrosine phosphatase, receptor type Gsynaptoporin
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPGSPO
Cytomap

3p14.2

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tsynaptoporin
Modification date2018052720180519
UniProtAcc

P23470

Q8TBG9

Ensembl transtripts involved in fusion geneENST00000295874, ENST00000474889, 
ENST00000495879, 
ENST00000478300, 
ENST00000295894, ENST00000479198, 
ENST00000478744, ENST00000460711, 
ENST00000465156, 
Fusion gene scores* DoF score11 X 6 X 7=4626 X 3 X 6=108
# samples 136
** MAII scorelog2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRG [Title/Abstract] AND SYNPR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A24D-01APTPRGchr3

61734656

+SYNPRchr3

63466508

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000295874ENST00000478300PTPRGchr3

61734656

+SYNPRchr3

63466508

+
Frame-shitENST00000295874ENST00000295894PTPRGchr3

61734656

+SYNPRchr3

63466508

+
Frame-shitENST00000295874ENST00000479198PTPRGchr3

61734656

+SYNPRchr3

63466508

+
5CDS-3UTRENST00000295874ENST00000478744PTPRGchr3

61734656

+SYNPRchr3

63466508

+
5CDS-3UTRENST00000295874ENST00000460711PTPRGchr3

61734656

+SYNPRchr3

63466508

+
5CDS-3UTRENST00000295874ENST00000465156PTPRGchr3

61734656

+SYNPRchr3

63466508

+
Frame-shitENST00000474889ENST00000478300PTPRGchr3

61734656

+SYNPRchr3

63466508

+
Frame-shitENST00000474889ENST00000295894PTPRGchr3

61734656

+SYNPRchr3

63466508

+
Frame-shitENST00000474889ENST00000479198PTPRGchr3

61734656

+SYNPRchr3

63466508

+
5CDS-3UTRENST00000474889ENST00000478744PTPRGchr3

61734656

+SYNPRchr3

63466508

+
5CDS-3UTRENST00000474889ENST00000460711PTPRGchr3

61734656

+SYNPRchr3

63466508

+
5CDS-3UTRENST00000474889ENST00000465156PTPRGchr3

61734656

+SYNPRchr3

63466508

+
3UTR-3CDSENST00000495879ENST00000478300PTPRGchr3

61734656

+SYNPRchr3

63466508

+
3UTR-3CDSENST00000495879ENST00000295894PTPRGchr3

61734656

+SYNPRchr3

63466508

+
3UTR-3CDSENST00000495879ENST00000479198PTPRGchr3

61734656

+SYNPRchr3

63466508

+
3UTR-3UTRENST00000495879ENST00000478744PTPRGchr3

61734656

+SYNPRchr3

63466508

+
3UTR-3UTRENST00000495879ENST00000460711PTPRGchr3

61734656

+SYNPRchr3

63466508

+
3UTR-3UTRENST00000495879ENST00000465156PTPRGchr3

61734656

+SYNPRchr3

63466508

+

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FusionProtFeatures for PTPRG_SYNPR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRG

P23470

SYNPR

Q8TBG9

Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}. Intrinsic membrane protein of small synaptic vesicles.Probable vesicular channel protein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRG_SYNPR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRG_SYNPR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRASYNPRFATE1, KIAA1715


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRG_SYNPR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRG_SYNPR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRGC0038356Stomach Neoplasms1CTD_human