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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29518

FusionGeneSummary for PTPRG_MCM3AP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG_MCM3AP
Fusion gene ID: 29518
HgeneTgene
Gene symbol

PTPRG

MCM3AP

Gene ID

5793

8888

Gene nameprotein tyrosine phosphatase, receptor type Gminichromosome maintenance complex component 3 associated protein
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPGGANP|MAP80|SAC3
Cytomap

3p14.2

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tgerminal-center associated nuclear protein80 kDa MCM3-associated proteinMCM3 acetylating proteinMCM3 acetyltransferaseMCM3 import proteinMCM3 minichromosome maintenance deficient 3 associated proteingerminal center-associated nuclear proteingermina
Modification date2018052720180519
UniProtAcc

P23470

O60318

Ensembl transtripts involved in fusion geneENST00000295874, ENST00000474889, 
ENST00000495879, 		ENST00000467026, 
ENST00000397708, ENST00000291688, 
Fusion gene scores* DoF score11 X 6 X 7=4621 X 2 X 1=2
# samples 131
** MAII scorelog2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: PTPRG [Title/Abstract] AND MCM3AP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-70-6722-01APTPRGchr3

61734656

+MCM3APchr21

47703752

-
TCGALDLUSCTCGA-70-6722-01APTPRGchr3

61734656

+MCM3APchr21

47700051

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295874ENST00000467026PTPRGchr3

61734656

+MCM3APchr21

47703752

-
5CDS-intronENST00000295874ENST00000397708PTPRGchr3

61734656

+MCM3APchr21

47703752

-
5CDS-intronENST00000295874ENST00000291688PTPRGchr3

61734656

+MCM3APchr21

47703752

-
5CDS-intronENST00000474889ENST00000467026PTPRGchr3

61734656

+MCM3APchr21

47703752

-
5CDS-intronENST00000474889ENST00000397708PTPRGchr3

61734656

+MCM3APchr21

47703752

-
5CDS-intronENST00000474889ENST00000291688PTPRGchr3

61734656

+MCM3APchr21

47703752

-
3UTR-intronENST00000495879ENST00000467026PTPRGchr3

61734656

+MCM3APchr21

47703752

-
3UTR-intronENST00000495879ENST00000397708PTPRGchr3

61734656

+MCM3APchr21

47703752

-
3UTR-intronENST00000495879ENST00000291688PTPRGchr3

61734656

+MCM3APchr21

47703752

-
5CDS-intronENST00000295874ENST00000467026PTPRGchr3

61734656

+MCM3APchr21

47700051

-
5CDS-intronENST00000295874ENST00000397708PTPRGchr3

61734656

+MCM3APchr21

47700051

-
5CDS-intronENST00000295874ENST00000291688PTPRGchr3

61734656

+MCM3APchr21

47700051

-
5CDS-intronENST00000474889ENST00000467026PTPRGchr3

61734656

+MCM3APchr21

47700051

-
5CDS-intronENST00000474889ENST00000397708PTPRGchr3

61734656

+MCM3APchr21

47700051

-
5CDS-intronENST00000474889ENST00000291688PTPRGchr3

61734656

+MCM3APchr21

47700051

-
3UTR-intronENST00000495879ENST00000467026PTPRGchr3

61734656

+MCM3APchr21

47700051

-
3UTR-intronENST00000495879ENST00000397708PTPRGchr3

61734656

+MCM3APchr21

47700051

-
3UTR-intronENST00000495879ENST00000291688PTPRGchr3

61734656

+MCM3APchr21

47700051

-

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FusionProtFeatures for PTPRG_MCM3AP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRG

P23470

MCM3AP

O60318

Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}. Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affectingsomatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNAprimers in very rapidely proliferating cells and would supportclonal expansion of differentiating B-cells (By similarity).Involved in the nuclear export of poly(A)-containing mRNAs byacting as a scaffold for the TREX-2 complex. The TREX-2 complexfunctions in docking export-competent ribonucleoprotein particles(mRNPs) to the nuclear entrance of the nuclear pore complex(nuclear basket). TREX-2 participates in mRNA export and accuratechromatin positioning in the nucleus by tethering genes to thenuclear periphery. {ECO:0000250, ECO:0000269|PubMed:22307388}. Isoform MCM3AP: Acetyltransferase targeting MCM3.Inhibits initiation of DNA replication, but not elongation.{ECO:0000269|PubMed:22307388}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRG_MCM3AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRG_MCM3AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRAMCM3APENY2, TMEM216, NUDT5, MCM3, TRIB3, CDC42, RAC1, APC, TERF2, CDC73, TAF1D, FAM118B, SUV39H2, TSC22D1, CLSTN1, SIRT7, SMAD9, SMAD3, LMNA, EP300, CDC25A, POLR2G, DDX39A, IER2, IFI16, NUP43, XPO1, BLM, KIFC3, MYH6, KLC4, CETN1, KIAA1683


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRG_MCM3AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRG_MCM3AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRGC0038356Stomach Neoplasms1CTD_human