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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29514

FusionGeneSummary for PTPRG_CADPS

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG_CADPS
Fusion gene ID: 29514
HgeneTgene
Gene symbol

PTPRG

CADPS

Gene ID

5793

8618

Gene nameprotein tyrosine phosphatase, receptor type Gcalcium dependent secretion activator
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPGCADPS1|CAPS|CAPS1|UNC-31
Cytomap

3p14.2

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tcalcium-dependent secretion activator 1CAPS-1Ca++-dependent secretion activatorCa2+ dependent secretion activatorCa2+-dependent activator protein for secretionCa2+-regulated cytoskeletal proteincalcium-dependent activator protein for secretion 1
Modification date2018052720180519
UniProtAcc

P23470

Q9ULU8

Ensembl transtripts involved in fusion geneENST00000295874, ENST00000474889, 
ENST00000495879, 
ENST00000383710, 
ENST00000357948, ENST00000283269, 
ENST00000490353, ENST00000462768, 
Fusion gene scores* DoF score11 X 6 X 7=4626 X 5 X 5=150
# samples 136
** MAII scorelog2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRG [Title/Abstract] AND CADPS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-7321-01APTPRGchr3

61548046

+CADPSchr3

62578423

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000295874ENST00000383710PTPRGchr3

61548046

+CADPSchr3

62578423

-
Frame-shitENST00000295874ENST00000357948PTPRGchr3

61548046

+CADPSchr3

62578423

-
Frame-shitENST00000295874ENST00000283269PTPRGchr3

61548046

+CADPSchr3

62578423

-
5CDS-intronENST00000295874ENST00000490353PTPRGchr3

61548046

+CADPSchr3

62578423

-
5CDS-intronENST00000295874ENST00000462768PTPRGchr3

61548046

+CADPSchr3

62578423

-
Frame-shitENST00000474889ENST00000383710PTPRGchr3

61548046

+CADPSchr3

62578423

-
Frame-shitENST00000474889ENST00000357948PTPRGchr3

61548046

+CADPSchr3

62578423

-
Frame-shitENST00000474889ENST00000283269PTPRGchr3

61548046

+CADPSchr3

62578423

-
5CDS-intronENST00000474889ENST00000490353PTPRGchr3

61548046

+CADPSchr3

62578423

-
5CDS-intronENST00000474889ENST00000462768PTPRGchr3

61548046

+CADPSchr3

62578423

-
3UTR-3CDSENST00000495879ENST00000383710PTPRGchr3

61548046

+CADPSchr3

62578423

-
3UTR-3CDSENST00000495879ENST00000357948PTPRGchr3

61548046

+CADPSchr3

62578423

-
3UTR-3CDSENST00000495879ENST00000283269PTPRGchr3

61548046

+CADPSchr3

62578423

-
3UTR-intronENST00000495879ENST00000490353PTPRGchr3

61548046

+CADPSchr3

62578423

-
3UTR-intronENST00000495879ENST00000462768PTPRGchr3

61548046

+CADPSchr3

62578423

-

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FusionProtFeatures for PTPRG_CADPS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRG

P23470

CADPS

Q9ULU8

Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}. Calcium-binding protein involved in exocytosis ofvesicles filled with neurotransmitters and neuropeptides. Probablyacts upstream of fusion in the biogenesis or maintenance of maturesecretory vesicles. Regulates catecholamine loading of DCVs. Mayspecifically mediate the Ca(2+)-dependent exocytosis of largedense-core vesicles (DCVs) and other dense-core vesicles by actingas a PtdIns(4,5)P2-binding protein that acts at prefusion stepfollowing ATP-dependent priming and participates in DCVs-membranefusion. However, it may also participate in small clear synapticvesicles (SVs) exocytosis and it is unclear whether its functionis related to Ca(2+) triggering (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRG_CADPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRG_CADPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRACADPSKIAA1549, SDCBP, TCL1A, C19orf66, FAM161A, ZNF572, FAM9B, TTLL10, C17orf67, CLIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRG_CADPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCADPSQ9ULU8DB11093Calcium CitrateCalcium-dependent secretion activator 1small moleculeapproved
TgeneCADPSQ9ULU8DB11348Calcium PhosphateCalcium-dependent secretion activator 1small moleculeapproved

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RelatedDiseases for PTPRG_CADPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRGC0038356Stomach Neoplasms1CTD_human