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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29512

FusionGeneSummary for PTPRG_BRD8

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG_BRD8
Fusion gene ID: 29512
HgeneTgene
Gene symbol

PTPRG

BRD8

Gene ID

5793

10902

Gene nameprotein tyrosine phosphatase, receptor type Gbromodomain containing 8
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPGSMAP|SMAP2|p120
Cytomap

3p14.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tbromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120
Modification date2018052720180519
UniProtAcc

P23470

Q9H0E9

Ensembl transtripts involved in fusion geneENST00000295874, ENST00000474889, 
ENST00000495879, 
ENST00000254900, 
ENST00000230901, ENST00000402931, 
ENST00000411594, ENST00000455658, 
ENST00000515014, 
Fusion gene scores* DoF score11 X 6 X 7=4623 X 3 X 3=27
# samples 133
** MAII scorelog2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPRG [Title/Abstract] AND BRD8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD8

GO:0043967

histone H4 acetylation

14966270

TgeneBRD8

GO:0043968

histone H2A acetylation

14966270


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-04-1651-01APTPRGchr3

61734656

+BRD8chr5

137481567

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000295874ENST00000254900PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000295874ENST00000230901PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000295874ENST00000402931PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000295874ENST00000411594PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000295874ENST00000455658PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000295874ENST00000515014PTPRGchr3

61734656

+BRD8chr5

137481567

-
Frame-shitENST00000474889ENST00000254900PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000474889ENST00000230901PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000474889ENST00000402931PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000474889ENST00000411594PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000474889ENST00000455658PTPRGchr3

61734656

+BRD8chr5

137481567

-
5CDS-intronENST00000474889ENST00000515014PTPRGchr3

61734656

+BRD8chr5

137481567

-
3UTR-3CDSENST00000495879ENST00000254900PTPRGchr3

61734656

+BRD8chr5

137481567

-
3UTR-intronENST00000495879ENST00000230901PTPRGchr3

61734656

+BRD8chr5

137481567

-
3UTR-intronENST00000495879ENST00000402931PTPRGchr3

61734656

+BRD8chr5

137481567

-
3UTR-intronENST00000495879ENST00000411594PTPRGchr3

61734656

+BRD8chr5

137481567

-
3UTR-intronENST00000495879ENST00000455658PTPRGchr3

61734656

+BRD8chr5

137481567

-
3UTR-intronENST00000495879ENST00000515014PTPRGchr3

61734656

+BRD8chr5

137481567

-

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FusionProtFeatures for PTPRG_BRD8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRG

P23470

BRD8

Q9H0E9

Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}. May act as a coactivator during transcriptionalactivation by hormone-activated nuclear receptors (NR). Isoform 2stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1,RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 arecomponents of the NuA4 histone acetyltransferase (HAT) complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. NuA4 may also play a direct role in DNArepair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histoneH2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:10517671,ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRG_BRD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRG_BRD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRABRD8RXRA, THRB, ING3, MRGBP, TP53, TP63, TP73, MORF4L1, MORF4L2, MYC, MAX, DMAP1, KAT5, SOX2, MIS18A, FSD2, PLAC1, FOXR1, FOXR2, HIST1H2BA, YEATS4, HIST1H2BG, EWSR1, TRRAP, CDC5L, EPC1, MBTD1, RUVBL1, RUVBL2, MYCL, MEAF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRG_BRD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRG_BRD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRGC0038356Stomach Neoplasms1CTD_human
TgeneBRD8C0014175Endometriosis1CTD_human