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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29497

FusionGeneSummary for PTPRD_RAC2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRD_RAC2
Fusion gene ID: 29497
HgeneTgene
Gene symbol

PTPRD

RAC2

Gene ID

5789

5880

Gene nameprotein tyrosine phosphatase, receptor type DRac family small GTPase 2
SynonymsHPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTAEN-7|Gx|HSPC022|p21-Rac2
Cytomap

9p24.1-p23

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase deltaR-PTP-deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase deltaras-related C3 botulinum toxin substrate 2Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)small G protein
Modification date2018052220180523
UniProtAcc

P23468

P15153

Ensembl transtripts involved in fusion geneENST00000381196, ENST00000360074, 
ENST00000537002, ENST00000397617, 
ENST00000358503, ENST00000397611, 
ENST00000355233, ENST00000356435, 
ENST00000540109, ENST00000486161, 
ENST00000397606, ENST00000463477, 
ENST00000471274, 
ENST00000249071, 
ENST00000406508, ENST00000405484, 
ENST00000401529, 
Fusion gene scores* DoF score10 X 11 X 5=5505 X 4 X 5=100
# samples 105
** MAII scorelog2(10/550*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRD [Title/Abstract] AND RAC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAC2

GO:0060263

regulation of respiratory burst

16636067


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A54X-01APTPRDchr9

10612398

-RAC2chr22

37637698

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000381196ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000381196ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000381196ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000381196ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000360074ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000360074ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000360074ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000360074ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000537002ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000537002ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000537002ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000537002ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000397617ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397617ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397617ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397617ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000358503ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000358503ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000358503ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000358503ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000397611ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397611ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397611ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397611ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000355233ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000355233ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000355233ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000355233ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000356435ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000356435ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000356435ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000356435ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000540109ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000540109ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000540109ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000540109ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000486161ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000486161ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000486161ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000486161ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000397606ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397606ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397606ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000397606ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
5UTR-3CDSENST00000463477ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
5UTR-5UTRENST00000463477ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
5UTR-5UTRENST00000463477ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
5UTR-5UTRENST00000463477ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-3CDSENST00000471274ENST00000249071PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000471274ENST00000406508PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000471274ENST00000405484PTPRDchr9

10612398

-RAC2chr22

37637698

-
intron-5UTRENST00000471274ENST00000401529PTPRDchr9

10612398

-RAC2chr22

37637698

-

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FusionProtFeatures for PTPRD_RAC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRD

P23468

RAC2

P15153

Can bidirectionally induce pre- and post-synapticdifferentiation of neurons by mediating interaction with IL1RAPand IL1RAPL1 trans-synaptically. Involved in pre-synapticdifferentiation through interaction with SLITRK2.{ECO:0000250|UniProtKB:Q64487}. Plasma membrane-associated small GTPase which cyclesbetween an active GTP-bound and inactive GDP-bound state. Inactive state binds to a variety of effector proteins to regulatecellular responses, such as secretory processes, phagocytose ofapoptotic cells and epithelial cell polarization. Augments theproduction of reactive oxygen species (ROS) by NADPH oxidase.{ECO:0000269|PubMed:1660188}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRD_RAC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRD_RAC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRDPPFIA1, PTPRS, LPAR6, IL2RG, SCN2B, LRRTM2, PPFIA2, PPFIA3, EGFR, COPG2, HADHA, HADHB, TPP2, DSC3, TRIO, LRRN1, PCDHB16, PIANP, LITAF, CD83, ICOSLG, PMEL, PCDH20, IZUMO1, GPR37, ABCG8, PCDHGB4, LILRB4, C19orf45, ARHGAP36, IL17RD, LINGO2, FYN, STMN4, MILR1, TMEM52B, RPL28, TPCN2, TMEM223, NLGN3, IL20RA, MTNR1A, MTNR1B, TRIM25RAC2CUL1, DEF6, ACTB, DOCK2, NCF2, ICMT, NOS2, ARHGDIB, PAK2, ARHGDIA, CHGB, AFG3L2, VCAM1, ITGA4, CD81, HDAC10, ADAM22, FBXO6, U2AF2, AGAP2, RAC3, DOCK1, ELMO2, RAP1GDS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PTPRD_RAC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRD_RAC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRDC0009404Colorectal Neoplasms2CTD_human
HgenePTPRDC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTPRDC0035258Restless Legs Syndrome1CTD_human
HgenePTPRDC1263846Attention deficit hyperactivity disorder1CTD_human
HgenePTPRDC1458155Mammary Neoplasms1CTD_human
TgeneRAC2C0018799Heart Diseases1CTD_human
TgeneRAC2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRAC2C0024299Lymphoma1CTD_human
TgeneRAC2C0025202melanoma1CTD_human
TgeneRAC2C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRAC2C1842398Neutrophil Immunodeficiency Syndrome1CTD_human;ORPHANET;UNIPROT