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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29495

FusionGeneSummary for PTPRD_IDO1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRD_IDO1
Fusion gene ID: 29495
HgeneTgene
Gene symbol

PTPRD

IDO1

Gene ID

5789

3620

Gene nameprotein tyrosine phosphatase, receptor type Dindoleamine 2,3-dioxygenase 1
SynonymsHPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTAIDO|IDO-1|INDO
Cytomap

9p24.1-p23

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase deltaR-PTP-deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase deltaindoleamine 2,3-dioxygenase 1indolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenase
Modification date2018052220180519
UniProtAcc

P23468

P14902

Ensembl transtripts involved in fusion geneENST00000381196, ENST00000360074, 
ENST00000537002, ENST00000397617, 
ENST00000358503, ENST00000397611, 
ENST00000355233, ENST00000356435, 
ENST00000540109, ENST00000486161, 
ENST00000397606, ENST00000463477, 
ENST00000471274, 		ENST00000522495, 
ENST00000518237, 
Fusion gene scores* DoF score10 X 11 X 5=5504 X 4 X 4=64
# samples 104
** MAII scorelog2(10/550*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRD [Title/Abstract] AND IDO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-7407-01APTPRDchr9

8733780

-IDO1chr8

39771408

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000381196ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000381196ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000360074ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000360074ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000537002ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000537002ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000397617ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000397617ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000358503ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000358503ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000397611ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000397611ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000355233ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000355233ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000356435ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000356435ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000540109ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000540109ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000486161ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000486161ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000397606ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000397606ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000463477ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
5CDS-5UTRENST00000463477ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+
intron-5UTRENST00000471274ENST00000522495PTPRDchr9

8733780

-IDO1chr8

39771408

+
intron-5UTRENST00000471274ENST00000518237PTPRDchr9

8733780

-IDO1chr8

39771408

+

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FusionProtFeatures for PTPRD_IDO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRD

P23468

IDO1

P14902

Can bidirectionally induce pre- and post-synapticdifferentiation of neurons by mediating interaction with IL1RAPand IL1RAPL1 trans-synaptically. Involved in pre-synapticdifferentiation through interaction with SLITRK2.{ECO:0000250|UniProtKB:Q64487}. Catalyzes the first and rate limiting step of thecatabolism of the essential amino acid tryptophan along thekynurenine pathway (PubMed:17671174). Involved in the peripheralimmune tolerance, contributing to maintain homeostasis bypreventing autoimmunity or immunopathology that would result fromuncontrolled and overreacting immune responses (PubMed:25691885).Tryptophan shortage inhibits T lymphocytes division andaccumulation of tryptophan catabolites induces T-cell apoptosisand differentiation of regulatory T-cells (PubMed:25691885). Actsas a suppressor of anti-tumor immunity (PubMed:23103127,PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits thegrowth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immunerejection (PubMed:25691885). {ECO:0000269|PubMed:14502282,ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127,ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRD_IDO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRD_IDO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRDPPFIA1, PTPRS, LPAR6, IL2RG, SCN2B, LRRTM2, PPFIA2, PPFIA3, EGFR, COPG2, HADHA, HADHB, TPP2, DSC3, TRIO, LRRN1, PCDHB16, PIANP, LITAF, CD83, ICOSLG, PMEL, PCDH20, IZUMO1, GPR37, ABCG8, PCDHGB4, LILRB4, C19orf45, ARHGAP36, IL17RD, LINGO2, FYN, STMN4, MILR1, TMEM52B, RPL28, TPCN2, TMEM223, NLGN3, IL20RA, MTNR1A, MTNR1B, TRIM25IDO1PPP1R16A, TERF2IP, APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRD_IDO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIDO1P14902DB00435Nitric OxideIndoleamine 2,3-dioxygenase 1small moleculeapproved

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RelatedDiseases for PTPRD_IDO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRDC0009404Colorectal Neoplasms2CTD_human
HgenePTPRDC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTPRDC0035258Restless Legs Syndrome1CTD_human
HgenePTPRDC1263846Attention deficit hyperactivity disorder1CTD_human
HgenePTPRDC1458155Mammary Neoplasms1CTD_human
TgeneIDO1C0011570Mental Depression4PSYGENET
TgeneIDO1C0011581Depressive disorder4PSYGENET
TgeneIDO1C0014175Endometriosis1CTD_human
TgeneIDO1C0021368Inflammation1CTD_human
TgeneIDO1C0027643Neoplasm Recurrence, Local1CTD_human
TgeneIDO1C0028754Obesity1CTD_human
TgeneIDO1C0043094Weight Gain1CTD_human
TgeneIDO1C0178417Anhedonia1PSYGENET
TgeneIDO1C0338715Drug-induced depressive state1PSYGENET
TgeneIDO1C0524851Neurodegenerative Disorders1CTD_human
TgeneIDO1C0581391Chronic depression1PSYGENET
TgeneIDO1C1458155Mammary Neoplasms1CTD_human