FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29494

FusionGeneSummary for PTPRD_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRD_FAU
Fusion gene ID: 29494
HgeneTgene
Gene symbol

PTPRD

FAU

Gene ID

5789

2197

Gene nameprotein tyrosine phosphatase, receptor type DFAU, ubiquitin like and ribosomal protein S30 fusion
SynonymsHPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTAFAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

9p24.1-p23

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase deltaR-PTP-deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase deltaubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052220180522
UniProtAcc

P23468

P62861

Ensembl transtripts involved in fusion geneENST00000381196, ENST00000360074, 
ENST00000537002, ENST00000397617, 
ENST00000358503, ENST00000397611, 
ENST00000355233, ENST00000356435, 
ENST00000540109, ENST00000486161, 
ENST00000397606, ENST00000463477, 
ENST00000471274, 
ENST00000529639, 
ENST00000531743, ENST00000525297, 
ENST00000527548, ENST00000279259, 
ENST00000529259, ENST00000434372, 
Fusion gene scores* DoF score10 X 11 X 5=5507 X 6 X 2=84
# samples 107
** MAII scorelog2(10/550*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRD [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DR979128PTPRDchr9

8316140

+FAUchr11

64888180

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000381196ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000381196ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000381196ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000381196ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000381196ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000381196ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000381196ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000360074ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000360074ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000360074ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000360074ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000360074ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000360074ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000360074ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000537002ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000537002ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000537002ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000537002ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000537002ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000537002ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000537002ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397617ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397617ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397617ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397617ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000397617ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000397617ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000397617ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000358503ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000358503ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000358503ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000358503ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000358503ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000358503ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000358503ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397611ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397611ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397611ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397611ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000397611ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000397611ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000397611ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000355233ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000355233ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000355233ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000355233ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000355233ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000355233ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000355233ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000356435ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000356435ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000356435ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000356435ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000356435ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000356435ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000356435ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000540109ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000540109ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000540109ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000540109ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000540109ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000540109ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000540109ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000486161ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000486161ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000486161ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000486161ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000486161ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000486161ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000486161ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397606ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397606ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397606ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000397606ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000397606ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000397606ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000397606ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000463477ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000463477ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000463477ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000463477ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000463477ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000463477ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000463477ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000471274ENST00000529639PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000471274ENST00000531743PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000471274ENST00000525297PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3CDSENST00000471274ENST00000527548PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000471274ENST00000279259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-3UTRENST00000471274ENST00000529259PTPRDchr9

8316140

+FAUchr11

64888180

-
intron-intronENST00000471274ENST00000434372PTPRDchr9

8316140

+FAUchr11

64888180

-

Top

FusionProtFeatures for PTPRD_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRD

P23468

FAU

P62861

Can bidirectionally induce pre- and post-synapticdifferentiation of neurons by mediating interaction with IL1RAPand IL1RAPL1 trans-synaptically. Involved in pre-synapticdifferentiation through interaction with SLITRK2.{ECO:0000250|UniProtKB:Q64487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PTPRD_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PTPRD_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PTPRD_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PTPRD_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRDC0009404Colorectal Neoplasms2CTD_human
HgenePTPRDC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTPRDC0035258Restless Legs Syndrome1CTD_human
HgenePTPRDC1263846Attention deficit hyperactivity disorder1CTD_human
HgenePTPRDC1458155Mammary Neoplasms1CTD_human