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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29491

FusionGeneSummary for PTPRD_C9orf92

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRD_C9orf92
Fusion gene ID: 29491
HgeneTgene
Gene symbol

PTPRD

C9orf92

Gene ID

5789

100129385

Gene nameprotein tyrosine phosphatase, receptor type Dchromosome 9 open reading frame 92
SynonymsHPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTAEm:AL513424.1
Cytomap

9p24.1-p23

9p22.3

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase deltaR-PTP-deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase deltaputative uncharacterized protein C9orf92
Modification date2018052220180329
UniProtAcc

P23468

A6NGG3

Ensembl transtripts involved in fusion geneENST00000381196, ENST00000360074, 
ENST00000537002, ENST00000397617, 
ENST00000358503, ENST00000397611, 
ENST00000355233, ENST00000356435, 
ENST00000540109, ENST00000486161, 
ENST00000397606, ENST00000463477, 
ENST00000471274, 
ENST00000380685, 
ENST00000380683, 
Fusion gene scores* DoF score10 X 11 X 5=5501 X 1 X 1=1
# samples 101
** MAII scorelog2(10/550*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PTPRD [Title/Abstract] AND C9orf92 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-5514-01APTPRDchr9

8633317

-C9orf92chr9

16215897

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000381196ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000381196ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000360074ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000360074ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000537002ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000537002ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000397617ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000397617ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000358503ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000358503ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000397611ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000397611ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000355233ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000355233ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000356435ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000356435ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000540109ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000540109ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000486161ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000486161ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000397606ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000397606ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000463477ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
5CDS-5UTRENST00000463477ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-
intron-5UTRENST00000471274ENST00000380685PTPRDchr9

8633317

-C9orf92chr9

16215897

-
intron-5UTRENST00000471274ENST00000380683PTPRDchr9

8633317

-C9orf92chr9

16215897

-

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FusionProtFeatures for PTPRD_C9orf92


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRD

P23468

C9orf92

A6NGG3

Can bidirectionally induce pre- and post-synapticdifferentiation of neurons by mediating interaction with IL1RAPand IL1RAPL1 trans-synaptically. Involved in pre-synapticdifferentiation through interaction with SLITRK2.{ECO:0000250|UniProtKB:Q64487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRD_C9orf92


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRD_C9orf92


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRDPPFIA1, PTPRS, LPAR6, IL2RG, SCN2B, LRRTM2, PPFIA2, PPFIA3, EGFR, COPG2, HADHA, HADHB, TPP2, DSC3, TRIO, LRRN1, PCDHB16, PIANP, LITAF, CD83, ICOSLG, PMEL, PCDH20, IZUMO1, GPR37, ABCG8, PCDHGB4, LILRB4, C19orf45, ARHGAP36, IL17RD, LINGO2, FYN, STMN4, MILR1, TMEM52B, RPL28, TPCN2, TMEM223, NLGN3, IL20RA, MTNR1A, MTNR1B, TRIM25C9orf92


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRD_C9orf92


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRD_C9orf92


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRDC0009404Colorectal Neoplasms2CTD_human
HgenePTPRDC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTPRDC0035258Restless Legs Syndrome1CTD_human
HgenePTPRDC1263846Attention deficit hyperactivity disorder1CTD_human
HgenePTPRDC1458155Mammary Neoplasms1CTD_human